Epidemiology, prognosis and treatment of simultaneous squamous cell carcinomas of the oral cavity and hypopharynx

Boute, P.; Page, C.; Biet, A.; Cuvelier, P.; Strunski, V.; Chevalier, Dominique

doi:10.1016/j.anorl.2013.10.003

Cited by 10 publications

(14 citation statements)

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“…According to previous studies, when a patient has ESCC or HSCC, there is a strong possibility of the presence of another SCC . In particular, the incidences of ESCC, HSCC, and OSCC are strongly interrelated; the presence of one is associated with an increased risk of the other . Based on this theory, we routinely screen patients with OSCC for the detection of ESCC or HSCC using esophagogastroduodenoscopy (EGD).…”

Section: Introductionmentioning

confidence: 99%

“…[18][19][20][21] In particular, the incidences of ESCC, HSCC, and OSCC are strongly interrelated; the presence of one is associated with an increased risk of the other. 22,23 Based on this theory, we routinely screen patients with OSCC for the detection of ESCC or HSCC using esophagogastroduodenoscopy (EGD). The aim of the present study was to assess the usefulness of modified EGD for the detection of ESCC or HSCC in patients with OSCC and determine the association between the subsite of the oral lesion and the occurrence of ESCC or HSCC.…”

Section: Introductionmentioning

confidence: 99%

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Detection of Second Primary Malignancies of the Esophagus and Hypophraynx in Oral Squamous Cell Carcinoma Patients

Matsui

Okada

Kawada

et al. 2018

Laryngoscope Investig Oto

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ObjectiveTo assess the usefulness of modified esophagogastroduodenoscopy (EGD) for the detection of second primary malignancies of the esophagus or hypopharynx in patients with oral squamous cell carcinoma and determine the association between the oral lesion subsite and esophageal or hypopharyngeal lesion occurrence.Study DesignRetrospective review.MethodsIn total, 166 patients with oral squamous cell carcinoma without any established symptoms of esophageal or hypopharyngeal squamous cell carcinoma underwent modified EGD based on the Valsalva maneuver and U‐turn method, image‐enhanced endoscopy, and chromoendoscopy using Lugol's iodine for diagnosis. All suspected lesions were biopsied to determine the clinical stages and duplication rates. Odds ratios for the occurrence of duplicate lesions according to the oral lesion subsite were determined.ResultsIn total, 37 esophageal and 16 hypopharyngeal lesions were detected. According to the Union for International Cancer Control/American Joint Committee on Cancer classification (2009), 75.7% and 5.4% esophageal lesions were classified as stage IA and IB, respectively, and 50% and 18.8% hypopharyngeal lesions as stage II and stage I, respectively. Approximately 59.1% and 50% esophageal and hypopharyngeal lesions, respectively, were successfully treated by endoscopic resection. Oral lesions involving the floor of the mouth were more frequently accompanied by second primary malignancies of the esophagus or hypopharynx.ConclusionsModified EGD is an effective noninvasive technique for early diagnosis and treatment of second primary malignancies of the esophagus and hypopharynx in patients with oral squamous cell carcinoma. In particular, patients with floor of the mouth lesions need close monitoring for hypopharyngeal and esophageal lesions.Level of Evidence3b.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detection of Second Primary Malignancies of the Esophagus and Hypophraynx in Oral Squamous Cell Carcinoma Patients

Matsui

Okada

Kawada

et al. 2018

Laryngoscope Investig Oto

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“…Radical surgery with or without postoperative adjuvant therapy (depending on the presence of pathological risk factors) remains the mainstay of treatment for OSCC patients. A secondary treatment strategy should be planned in OSCC patients who present with SSPT at the time of primary treatment [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Of note, approximately 5% of our OSCC patients present with concomitant HCC. However, the question as to whether OSCC patients with SSPT located at the liver or other at-risk sites should receive specific and/or targeted treatment approaches remains open [ 7 , 8 ]. In this scenario, we designed the current study to identify the main prognostic factors in OSCC patients with SSPT and incorporate them into a risk stratification scheme.…”

Section: Introductionmentioning

confidence: 99%

Clinical Outcomes of Patients with Resected Oral Cavity Cancer and Simultaneous Second Primary Malignancies

et al. 2015

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ObjectivesSimultaneous second primary tumors (SSPT) are not uncommon in patients with oral cavity squamous cell carcinoma (OSCC) living in areas where the habit of betel quid chewing is widespread. We sought to identify the main prognostic factors in OSCC patients with SSPT and incorporate them into a risk stratification scheme.MethodsA total of 1822 consecutive patients with primary OSCC treated between January 1996 and February 2014 were analyzed for the presence of SSPT. The 18-month and 5-year overall survival (OS) rates served as the main outcome measures.ResultsOf the 1822 patients, 77 (4%) were found to have SSPT (i.e, two malignancies identified within one month of each other). The 18-month and 5-year OS rates in patients without SSPT and with SSPT were 82% and 69%, and 72% and 53%, respectively (p = 0.0063). Patients with SSPT were further divided into patients with either esophageal cancer or hepatocellular carcinoma (eso-HCC subgroup, n = 8) and other tumors (NO eso-HCC subgroup, n = 69). After multivariate analysis, neck nodal extracapsular spread (ECS, n = 18) and the presence of eso-HCC were identified as independent adverse prognostic factors. The 18-month OS rates of SSPT patients with both eso-HCC and ECS (n = 5) vs. the remaining patients (n = 72) were 0% and 78%, respectively (p < 0.0001).ConclusionOSCC patients with neck nodal ECS and esophageal cancer or hepatocellular carcinoma as SSPT have a dismal short-term prognosis.

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“…A further reason for conducting triple endoscopy is the possibility of obtaining biopsies free of pain. It facilitates a better understanding of tumour extension with the prospect of defining a valid T category and/or determining the resectability of the lesion and reconstructive techniques [7]. Tumour extension must be comprehended via manual palpation as well as by the use of rigid instruments on collaptic tissue, because collaptic tissue can represent a problem in solely apparatus-based diagnostics.…”

Section: Introductionmentioning

confidence: 99%

Rigid Triple Endoscopy Improves Clinical Staging of Primary Head and Neck Cancer

Sharma

Linke²,

Kroll³

et al. 2018

Oncol Res Treat

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Background: Correct pre-therapeutic staging of the first primary carcinoma (FPC) and detection of simultaneous second primary carcinomas (SSPCs) decisively influence therapy and prognosis of head and neck squamous cell carcinomas (HNSCC). The aim of this study was to determine the benefit of pre-therapeutic triple endoscopy for detection of SSPC and pre-therapeutic T category. Methods: A cohort of 234 HNSCC patients with completed triple endoscopy was reviewed, focusing on pre-therapeutic T category and SSPC. Risk stratification for different subsites was evaluated. Results: The risk for SSPC was 5.56%. FPC of the oral cavity and oropharynx had the highest prevalence of SSPC (46.15%, 38.46%); most SSPCs were found in the hypopharynx. No SSPCs were found in the oral cavity, nasopharynx and oesophagus. Significant results in correct pre-therapeutic T staging have been achieved for the larynx (p = 0.021) and the oropharynx (p = 0.001). Conclusions: Triple endoscopies seem to be inadequate for SSPC detection in HNSCC patients. Endoscopies of the trachea and oesophagus should be reconsidered. Alternatively, risk-directed endoscopies of the hypopharynx might be performed in patients with oral cancer. For evaluation of resectability, conducting triple endoscopy could be reduced to a single endoscopy because the complication rate is low and pre-therapeutic T staging can be improved.

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Epidemiology, prognosis and treatment of simultaneous squamous cell carcinomas of the oral cavity and hypopharynx

Cited by 10 publications

References 10 publications

Detection of Second Primary Malignancies of the Esophagus and Hypophraynx in Oral Squamous Cell Carcinoma Patients

Detection of Second Primary Malignancies of the Esophagus and Hypophraynx in Oral Squamous Cell Carcinoma Patients

Clinical Outcomes of Patients with Resected Oral Cavity Cancer and Simultaneous Second Primary Malignancies

Rigid Triple Endoscopy Improves Clinical Staging of Primary Head and Neck Cancer

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