Epidemiology of Uveitis

Wakefield, Denis; Chang, John H

doi:10.1097/01.iio.0000155938.83083.94

Cited by 212 publications

(142 citation statements)

References 50 publications

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“…Most of the previous studies reported equal sex distribution (3,4,10,12,20,21). There are, however, studies stating a female (6,13,16,22) or male (9,(23)(24)(25) predominance.…”

Section: Discussionmentioning

confidence: 72%

“…It is an important cause of visual impairment throughout the world, accounting for about 10% of all legally blind individuals and leading to a significant personal and population burden (2,3). Uveitis has various clinical patterns and characteristics influenced by multiple factors like genetic, geographic, and environmental factors and diagnostic criteria (4).…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology of uveitis in a referral hospital in Turkey

Özdal¹,

Yazıcı²,

Tüfek³

et al. 2014

Turk J Med Sci

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A series of (E) -3- (3-(2,3-dihydro-3-methyl-2-oxo-3 H -benzoxazole-6-yl)-1-phenyl-1 H -pyrazole-4-yl)acrylamides (7a-k) were synthesized and evaluated for their in vitro inhibitory activities on COX-1 and COX-2 isoforms using a human whole blood assay as well as their antiplatelet profile against human platelet aggregation using arachidonic acid as agonists. Among the synthesized derivatives 7a-k, especially compound 7g exhibited dual anti-inflammatory and antiplatelet activity with selective COX-2 inhibition.

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“…Most of the previous studies reported equal sex distribution (3,4,10,12,20,21). There are, however, studies stating a female (6,13,16,22) or male (9,(23)(24)(25) predominance.…”

Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Epidemiology of uveitis in a referral hospital in Turkey

Özdal¹,

Yazıcı²,

Tüfek³

et al. 2014

Turk J Med Sci

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“…12 Our findings correspond well to previous reports, 7,10,13 which described CMV-associated AU in the immunocompetent host, presenting mostly as a recurrent unilateral hypertensive AU, sometimes associated with typical corneal endothelial precipitates, iris atrophy, and the absence of posterior synechiae. 6,7,14,15 In these previous studies, PCR was used as a main diagnostic tool. Our data demonstrate that GWC analysis can contribute to the diagnosis of CMV AU as 4/10 patients were diagnosed solely by GWC.…”

Section: Discussionmentioning

confidence: 99%

Viral causes of unexplained anterior uveitis in Thailand

Kongyai

Sirirungsi

Pathanapitoon

et al. 2012

Eye

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Aims To assess the possible role of virus infection in patients with unexplained anterior uveitis (AU). Methods Intraocular fluid and plasma samples of 30 HIV-negative AU patients who were unresponsive or poorly responsive to topical steroid therapy were analyzed for nucleic acid of cytomegalovirus (CMV), herpes simplex virus (HSV), and varicella zoster virus (VZV) by realtime polymerase chain reaction (PCR) and for intraocular antibodies against these viruses by Goldmann-Witmer coefficient (GWC) analysis. Of these 30 cases, 21 were tested for rubella virus by GWC analysis, 16 of which also had PCR assessment of aqueous for rubella virus. Results Viral uveitis determined by either real-time PCR and/or GWC was documented in 20 out of 30 patients (67%). Of 30 paired samples tested by both methods for HSV, CMV, and VZV, 15 showed positive results (CMV (10), HSV (4), and VZV (1)). Real-time PCR was positive in 8/15 (53%), whereas GWC was positive in 10/15 (67%). Out of 10 CMV-positive patients, four had endotheliitis, two had Posner-Schlossman syndrome, and one Fuchs heterochromic uveitis syndrome (FHUS). Five out of 21 (24%) samples tested by GWC for Rubella virus were positive, three of which exhibited clinical features of FHUS. Conclusions Our results indicate that CMV is a major cause of AU in Thailand and show that FHUS can be caused by both CMV and Rubella virus.

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“…80,81 It is unknown as to whether the immune processes occurring intraocularly in idiopathic uveitis are the same as those in which a systemic immune disease is also present. This is because, where there is an associated systemic disease, the ocular inflammatory activity does not necessarily parallel systemic inflammation.…”

Section: Cytokines and Chemokines In Patients With Uveitismentioning

confidence: 99%