Epidemiology of SEN virus infection among patients with hepatitis B and C in China

Moriyama, Mitsuhiko; Mikuni, Morio; Long-ren, WU; Zhao, Ziyi; Wang, Xueqing; Oshiro, Shuh; Matsumura, Hiroshi; Aoki, Hiroshi; Ichijima, Sagiri; Iwasaki, H.; Tanaka, Naohide; Abe, Kenji; Arakawa, Yasuyuki

doi:10.1016/s1386-6346(03)00238-9

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…Recently, altered gene expression was associated with the induction and maintenance of HCC [2][3][4]. The identification of novel genes that related to liver functions, especially those differentially expressed in the liver and HCC tissues, would be helpful in understanding the pathogenesis of HCC, and may facilitate the diagnosis and treatment of HCC.…”

Section: Introductionmentioning

confidence: 99%

Decreased expression of the human carbonyl reductase 2 gene HCR2 in hepatocellular carcinoma

Liu

Huang

et al. 2006

Cellular and Molecular Biology Letters

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Altered gene expression was associated with the induction and maintenance of hepatocellular carcinoma (HCC). To determine the significance of HCR2 in HCC, here we compare the expression levels of HCR2 in carcinoma and in paired non-carcinoma tissues using semiquantitative reverse-transcription polymerase chain reaction (RT-PCR), Western blot analysis, and immunohistochemical staining. The expression ratio (ER) of HCR2 between the tumor and paired tumor-free tissues was calculated for each case and the data was clinicopathologically analyzed. The expression of HCR2 mRNA was found to be significantly decreased in HCC tissues compared with paired normal tissues (P < 0.001). HCR2 was downregulated in 58% (n = 22) of 38 HCC patients. The ER of HCR2 was higher in Edmondson's grade I/II carcinomas than that in Edmondson's grade III/IV carcinomas (P < 0.05). Western blot analysis showed HCR2 to be notably depressed in carcinoma tissues in 3 out of 4 HCC patients. Immunohistochemical staining indicated most HCR2 protein accumulated in non-carcinoma cells. These results suggested that altered HCR2 expression might play roles in the carcinogenesis and progression of HCC, and it could be a clinical marker for prognosis, and a molecular target for screening potential anti-HCC drugs.

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Section: Introductionmentioning

confidence: 99%

Decreased expression of the human carbonyl reductase 2 gene HCR2 in hepatocellular carcinoma

Liu

Huang

et al. 2006

Cellular and Molecular Biology Letters

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“…The differences were not significant. DNA in non-A to -G liver disease in Japan and in type B and type C liver disease in China (16,17). From these results, we concluded that SEN-V infection did not affect the serological features of non-A to -G liver disease and type B and type C chronic liver diseases.…”

Section: Phylogenetic Tree Analysismentioning

confidence: 81%

“…Analysis of the nucleotide sequences from SEN-V DNA-positive subjects (NU isolates; Nos. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] revealed that they shared 86-98% identity with one another and 78-85% identity with SEN-V genotype A, 86-96% with genotype B, 88-93% with genotype C, 86-89% with genotype D, 81-90% with genotype E, 85-91% with genotype F, 83-88% with genotype G and 88-92% with genotype H. The NU isolates shared 80-97% identity with the China isolates (17), 85-98% identity with the isolates from blood donors (16), 82-87% identity with the SANBAN isolates of TTV, 78-81% identity with the YONBAN isolate of TTV, 86-90% identity with the TTV prototype isolate (TA278), and 85-89% identity with the PMV isolate ( Table 5) The difference between two groups was not statistically significant. nucleotide sequences of SEN-V genotypes A to H and the 12 NU isolates revealed many nucleotide substitutions between nt 70 and 88, and nt 142 and 170 (Fig.…”

Section: Sequence Analysismentioning

confidence: 99%

SEN virus infection influences the pathological findings in liver but does not affect the incidence of hepatocellular carcinoma in patients with chronic hepatitis C and liver cirrhosis

Moriyama

Mikuni

Matsumura

et al. 2005

Liver International

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The Associated Ion between the VDR Gene Polymorphisms and Susceptibility to Hepatocellular Carcinoma and the Clinicopathological Features in Subjects Infected with HBV

Yao

Zeng

Zhang

et al. 2013

BioMed Research International

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Aim. To evaluate the possible association between the vitamin D receptor (VDR), single-nucleotide polymorphisms (SNPs), and hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection. Method. 968 chronic HBV infection patients were enrolled, of which 436 patients were diagnosed HCC patients, and 532 were non-HCC patients. The clinicopathological characteristics of HCC were evaluated. The genotypes of VDR gene at FokI, BsmI, ApaI, and TaqI were determined. Results. The genotype frequencies of VDR FokI C>T polymorphism were significantly different between HCC and non-HCC groups. HCC patients had a higher prevalence of FokI TT genotype than non-HCC subjects. With FokI CC as reference, the TT carriage had a significantly higher risk for development of HCC after adjustments with age, sex, HBV infection time, α-fetoprotein, smoking status, and alcohol intake. In addition, we also found that the TT genotype carriage of FokI polymorphisms were associated with advanced tumor stage, presence of cirrhosis, and lymph node metastasis. The SNP at BsmI, ApaI, and TaqI did not show positive association with the risk and clinicopathological features of HCC. Conclusion. The FokI C>T polymorphisms may be used as a molecular marker to predict the risk and to evaluate the disease severity of HCC in those infected with HBV.

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Epidemiology of SEN virus infection among patients with hepatitis B and C in China

Cited by 4 publications

References 22 publications

Decreased expression of the human carbonyl reductase 2 gene HCR2 in hepatocellular carcinoma

Decreased expression of the human carbonyl reductase 2 gene HCR2 in hepatocellular carcinoma

SEN virus infection influences the pathological findings in liver but does not affect the incidence of hepatocellular carcinoma in patients with chronic hepatitis C and liver cirrhosis

The Associated Ion between the VDR Gene Polymorphisms and Susceptibility to Hepatocellular Carcinoma and the Clinicopathological Features in Subjects Infected with HBV

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