Epidemiology of Pemphigus in Tehran, Iran: A 20-Year Retrospective Study

Abdolsamadi, Hamid Reza; Abdollahzadeh, Shermin; Vaziri, P Bakianian; Beheshti, Akram; Shafigh, Elnaz; Vahedi, Mohammad

doi:10.5681/joddd.2007.019

Cited by 4 publications

(2 citation statements)

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“…Pemphigus is observed more frequently in women according to most of the literature [ 7 , 23 , 31 ]. In a retrospective study by Abdolsamadi et al in which they examined 20 years of data on patients with pemphigus in Tehran, 380 (56.9%) patients with PV with only oral mucosal involvement were females, while 288 (43.1%) were males [ 32 ]. In the same study, 146 (62.9%) of 232 patients with oral mucosa and skin involvement were females and 86 (37.1%) were males [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…In a retrospective study by Abdolsamadi et al in which they examined 20 years of data on patients with pemphigus in Tehran, 380 (56.9%) patients with PV with only oral mucosal involvement were females, while 288 (43.1%) were males [ 32 ]. In the same study, 146 (62.9%) of 232 patients with oral mucosa and skin involvement were females and 86 (37.1%) were males [ 32 ]. In the study conducted by Arduino et al with patients with OPV in Italy, 62.25% of the patients were females [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the Quality of Life and the Demographic and Clinical Characteristics of Patients With Pemphigus With Oral Mucosal İnvolvement: A Multicenter Observational Study

Kara Polat,

Mülayim,

Falay Gür

et al. 2024

Dermatology Practical &Amp; Conceptual

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Introduction: Pemphigus vulgaris (PV) is an autoimmune disease that mostly affects the oral mucosa. Objectives: This study aimed to determine the demographic, clinical and treatment characteristics as well as the quality of life of patients with PV and oral mucosal involvement. Methods: We conducted a prospective observational study among 106 patients with PV and oral mucosal involvement. Demographic data, clinical and treatment characteristics, and quality of life questionnaires were recorded. Results: Of the 106 patients, 51.89% were males. Mucocutaneous subtype was found in 78.38% of the patients. The initial localization of 41.51% of the patients was only the oral mucosa. Involvement of the bilateral buccal mucosa was observed most frequently in the patients and burning was the most common symptom (85.85%). Oral mucosal examination revealed erosions in 85.85% of the patients. The most frequently used treatment agent in the patients was a systemic steroid, and rituximab used in 16.98% patients. A positive and significant correlation was found between pemphigus severity and OHIP14-TR, DLQI, and DYQS scores (p < 0.05). The quality of life was more significantly adversely affected in those with superficial ulcers, loose bullae, lesion diameter of 1 cm and above, and the number of lesions above 10 in the oral mucosa. Complet response was observed in all patients using rituximab. Conclusions: The most common area of involvement was bilateral buccal mucosa, and the quality of life was affected in correlation with the severity of the disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of the Quality of Life and the Demographic and Clinical Characteristics of Patients With Pemphigus With Oral Mucosal İnvolvement: A Multicenter Observational Study

Kara Polat,

Mülayim,

Falay Gür

et al. 2024

Dermatology Practical &Amp; Conceptual

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Secretor Status of ABO Antigens in Saliva of a Defined Group of Iranian Patients with Pemphigus Vulgaris: A Case-Control Study

et al. 2020

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Introduction. Pemphigus is a chronic inflammatory and autoimmune disease which can cause blisters and mucocutaneous erosions. ABO secretor refers to those who secrete ABO blood group antigens based on their blood type in body fluids such as saliva, sweat, tears, semen, and serum. Previous studies showed that nonsecretor people are more prone to certain autoimmune diseases. Aim. The aim of this study was to determine the ABO secretor status in the saliva of patients with pemphigus vulgaris. Materials and Methods. This case-control study was conducted on 35 patients with pemphigus vulgaris and 35 healthy controls. The two groups were matched for age and gender. Pemphigus vulgaris diagnosis was confirmed by histopathology and direct immunofluorescence microscopy. ABO blood grouping was done, and 5 ml of unstimulated saliva was collected to determine secretor status. Secretors were recognized from nonsecretors by the Wiener agglutination inhibition test. Results were extracted by using statistical chi-square and Fisher’s exact tests. Results. 16 male and 19 female patients aged 49.43 ± .12.37 years were compared with 16 male and 19 female controls aged 46.43 ± 11.88 years. The most frequent blood group among case and control groups was O (54.3% and 60%, respectively). There was no significant difference in blood groups (P=0.73). 90% of the samples were ABO secretors. The patient group included 31 (88.6%) and the control group included 32 (91.4%) ABO secretors; there was no significant difference between the two groups (P=1.000). Conclusion. In this study, we observed that the people with nonsecretor status in comparison with the people with secretor status are not more susceptible to develop pemphigus vulgaris.

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Spectrum of autoimmune vesiculobullous diseases in Iran: a 13-year retrospective study

Sobhan

Farshchian

Tamimi

2016

CCID

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BackgroundAutoimmune bullous diseases (ABDs) represent a group of rare, acquired disorders characterized by overlapping features with involvement of the skin and mucous membranes, resistance to treatment, and potential lethality that comprise pemphigus, bullous pemphigoid (BP), epidermolysis bullosa, dermatitis herpetiformis, and linear immunoglobulin A bullous dermatosis.AimThe main aim of this study was to identify the epidemiologic characteristics and clinical courses of these common diseases in Hamadan, Iran. Few surveys have been carried out to demonstrate the whole spectrum of ABDs in the literature. Notably, in Hamadan we are the first.Materials and methodsThis 13-year retrospective study was designed to evaluate all of documented data obtained from hospitalized patients with ABDs at Farshchian Hospital from October 1999 to October 2012. We collected information on epidemiologic data, clinical aspects, histologic findings, and therapy prescribed. Data were analyzed using SPSS.ResultsOf 168 patients, 78% had pemphigus. The age of patients at presentation ranged from 1 month to 115 years, with a mean of 47.5±19.93 years. Mucosal or skin involvement of ABDs was statistically significant (P<0.001). The incidence of ABDs differed significantly based on anatomic location (P=0.003). We documented three deaths.ConclusionCompared to previous literature, our findings showed equal epidemiologic properties in Iran. Although pemphigus was the most common ABD followed by BP, it is expected that in line with the global trend, an increase in BP will be driven by population aging in Iran.

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Epidemiology of Pemphigus in Tehran, Iran: A 20-Year Retrospective Study

Cited by 4 publications

References 15 publications

Evaluation of the Quality of Life and the Demographic and Clinical Characteristics of Patients With Pemphigus With Oral Mucosal İnvolvement: A Multicenter Observational Study

Evaluation of the Quality of Life and the Demographic and Clinical Characteristics of Patients With Pemphigus With Oral Mucosal İnvolvement: A Multicenter Observational Study

Secretor Status of ABO Antigens in Saliva of a Defined Group of Iranian Patients with Pemphigus Vulgaris: A Case-Control Study

Spectrum of autoimmune vesiculobullous diseases in Iran: a 13-year retrospective study

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