Epidemiology of pediatric tumors of the nervous system according to the WHO 2000 classification: a report of 1,195 cases from a single institution

Rosemberg, Sérgio; Fujiwara, Dirce

doi:10.1007/s00381-005-1181-x

Cited by 135 publications

(106 citation statements)

References 14 publications

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“…Acreditamos que tais diferenças possam refletir um número reduzido (provavelmente pela sub-referência) de astrocitomas de baixo grau (apenas 18% do total de tumores na nossa série). Em uma série epidemiológica de 1.195 pacientes pediátricos com tumores cerebrais operados no Hospital das Clínicas de São Paulo, entre 1974 e 2003, 24,4% dos diagnósticos foram de astrocitomas de baixo grau 21 . Quanto aos ependimomas, os nossos resultados estão na faixa dos resultados do SEER até 1984 (39% versus 33%).…”

Section: Discussionunclassified

Analysis of survival and prognostic factors of pediatric patients with brain tumor

Araújo¹,

Trindade²,

Trompieri³

et al. 2011

J Pediatr (Rio J)

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Objectives: To estimate survival and evaluate prognostic factors of pediatric patients with central nervous system (CNS) tumors treated in a single center. Methods:Retrospective analysis of survival of 103 children with primary brain tumors diagnosed consecutively from January 2000 to December 2006. Cox regression was used for multivariate analysis of factors that affect overall survival to define possible prognostic factors.Results: Median and mean ages were 7.2 and 7.6 years. There was a male predominance (1.22:1). Most patients had medulloblastomas or primitive neuroectodermal tumors (PNET, 38%), or low-grade astrocytomas (18%). The anatomic site of most tumors was the cerebellum (49%) and the brain stem (21%). Five-year survival after diagnosis was 84% for low-grade astrocytomas and 51% for medulloblastomas and PNET. Prognostic factors for overall survival were histopathological type (highgrade astrocytomas and ependymomas; hazard ratio = 3.7 to 3.9), surgery (hazard ratio of 0.5 for completely resected tumors) and radiotherapy (hazard ratio of 0.5 for patients who underwent radiotherapy). Conclusions:Overall survival of pediatric patients with brain tumors in this study was similar to that found in populations of the United States and Europe. The prognostic factors defined for overall survival are also similar to those published in previous studies. J Pediatr (Rio J). 2011;87(5):425-32:Brain neoplasms, survival analysis, prognostic. ResumoObjetivos: Realizar análise de sobrevida e avaliar, através de análise multivariada, a influência de diversas variáveis na sobrevida, definindo fatores prognósticos de pacientes pediátricos com tumores do sistema nervoso central (SNC) tratados em um único centro.Métodos: Analisamos, retrospectivamente, a sobrevida de 103 crianças portadoras de tumores cerebrais primários, diagnosticadas consecutivamente no período entre janeiro de 2000 e dezembro de 2006. Análise multivariada de fatores influenciando a sobrevida global por regressão de Cox foi usada para definir possíveis fatores prognósticos. Resultados:A mediana e a média de idade foram de 7,2 e 7,6 anos. Houve predominância do sexo masculino (relação 1,22:1). A maioria dos pacientes tinha meduloblastoma ou tumores neuroectodérmicos primitivos (PNET, 38%) ou astrocitomas de baixo grau (18%). As topografias mais comuns foram cerebelar (49%) e tronco cerebral (21%). A sobrevida, 5 anos após o diagnóstico, foi de 84% para astrocitomas de baixo grau e 51% para meduloblastomas e PNET. Fatores prognósticos para a sobrevida global foram histopatológico (astrocitomas de alto grau e ependimomas, razão de risco entre 3,7 e 3,9), cirurgia (razão de risco 0,5 para tumores completamente ressecados) e radioterapia (razão de risco 0,5 para pacientes que receberam radioterapia). Conclusões:A sobrevida global de pacientes pediátricos com tumores cerebrais neste estudo é comparável àquela dos registros populacionais dos Estados Unidos e Europa. Os fatores de prognóstico definidos para sobrevida global também se assemelham àqueles ...

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Section: Discussionunclassified

Analysis of survival and prognostic factors of pediatric patients with brain tumor

Araújo¹,

Trindade²,

Trompieri³

et al. 2011

J Pediatr (Rio J)

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“…76 Again, according to the site of origin, these can be meningeal (meningiomas), from the nerve roots/nerve root sheaths (neurofibromas and schwannomas); extraspinal tumors that invade the epidural space (neuroblastoma-ganglioneuroblastoma-ganglioneuroma spectrum); or lymphomas or primitive neuroectodermal tumors. 47,77 Pain is the most frequent presenting symptom for spinal tumors and can be diffuse or radicular. 72,74,78 Pain can be present in approximately 25%-30% of cases: It has been described as dull and aching and localized to the bone segments adjacent to the tumor.…”

Section: Neoplastic Disordersmentioning

confidence: 99%

Imaging of Back Pain in Children

Rodriguez¹,

Poussaint²

2009

AJNR Am J Neuroradiol

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SUMMARY:While back pain presents less frequently in children than in adults, it still poses a significant clinical challenge with respect to making a firm diagnosis and developing an effective treatment plan. When children have back pain and medical attention is sought, an underlying pathology is usually suspected. Pediatric patients are evaluated, first, with a complete clinical history and examination and, second, by an imaging work-up that is based on initial findings, including the child's age and size, signs and symptoms, and suspected etiology. This article describes 1) the epidemiology of back pain in children, 2) the imaging work-up used, and 3) the correlation of imaging findings with disease entities that may cause back pain in the pediatric patient. The list of diseases giving rise to back pain is not meant to be exhaustive but rather reflective of the most commonly identified pathologies and disorders among young children and adolescents, from athletic injuries to lethal cancers.ABBREVIATIONS: ALARA ϭ as low as reasonably achievable; ESR ϭ erythrocyte sedimentation rate; FSE ϭ fast spin-echo; 18 F ϭ fluorine 18; LCH ϭ Langerhans cell histiocytosis; LDH ϭ lactate dehydrogenase; MBP ϭ mechanical back pain; PET ϭ positron-emission tomography; RFA ϭ radio-frequency ablation, SPECT ϭ single-photon emission computed tomography; STIR ϭ short tau inversion recovery; 99m Tc-MDP ϭ technetium 99m methylene diphosphonate; WHO ϭ World Health Organization B ack pain in children presents less frequently than in adults. The incidence of back pain in adults has been estimated to be as high as 60%-80% 1 ; the actual incidence of back pain in children, however, is unknown. Back pain in children presenting to the emergency department was originally thought to be an uncommon complaint, 2 reflecting significant underlying pathology compared with adults. Although recent studies have shown an increased prevalence of back pain in children, [3][4][5][6][7] relatively few patients receive medical attention.

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“…These tumors occur most frequently in patients between the ages of 0 and 14 years with a predilection for the infratentorial region. 1,2 Pilocytic astrocytoma is classified as a World Health Organization (WHO) grade I neoplasm given its excellent prognosis and long-term progressionfree survival even after subtotal tumor resection. 2,3 However, approximately a fifth of the patients recur after resection 4 and undergo adjuvant therapy, which carries significant toxicity and morbidity.…”

mentioning

confidence: 99%

Pilocytic astrocytomas of the optic nerve and their relation to pilocytic astrocytomas elsewhere in the central nervous system

et al. 2013

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Pilocytic astrocytoma is a low-grade glioma that affects mostly children and young adults and can occur anywhere in the central nervous system. Pilocytic astrocytoma of the optic nerve is an equally indolent subtype that is occasionally associated with neurofibromatosis type 1. In earlier studies, this subtype was considered within the larger category of 'optic pathway glioma,' which included infiltrating astrocytomas and other hypothalamic tumors. However, there have been suggestions that gliomas in the optic nerve, and especially pilocytic astrocytoma of the optic nerve, are biologically different from tumors within the hypothalamus and other parts of the optic tract. Furthermore, the recent discovery of BRAF duplication and fusion with the KIAA1549 gene is reported to be more typical for posterior fossa tumors, and the rate of this aberration is not well known in pilocytic astrocytoma of the optic nerve. To determine the distinction of pilocytic astrocytoma of the optic nerve from pilocytic astrocytoma of the posterior fossa and to investigate the prevalence of BRAF aberrations, we reviewed the clinicopathological and molecular features of all such patients in our institution. Our study demonstrates that BRAF duplication is more frequent in posterior fossa tumors compared with pilocytic astrocytoma of the optic nerve (P ¼ 0.011). However, the rates of phospho-MAPK1 and CDKN2A expression were high in both pilocytic astrocytoma of the optic nerve and posterior fossa pilocytic astrocytoma, suggesting that the MAPK pathway is active in these tumors. Our study supports the notion that BRAF duplication is more typical of posterior fossa pilocytic astrocytoma and that molecular alterations other than KIAA1549 fusion may underlie MAPK pathway activation in pilocytic astrocytoma of the optic nerve.

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Epidemiology of pediatric tumors of the nervous system according to the WHO 2000 classification: a report of 1,195 cases from a single institution

Cited by 135 publications

References 14 publications

Analysis of survival and prognostic factors of pediatric patients with brain tumor

Analysis of survival and prognostic factors of pediatric patients with brain tumor

Imaging of Back Pain in Children

Pilocytic astrocytomas of the optic nerve and their relation to pilocytic astrocytomas elsewhere in the central nervous system

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