Epidemiology of osteochimionecrosis of the jaws in France, update of data since 2015

Legendre, Q; Faillie, Jl; Lapeyrie, P; Tramini, Paul; Maladiere, E; Torres, JH; Lallemant, Benjamin

doi:10.1016/j.jormas.2021.12.015

Cited by 2 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although there are many publications on the management of MRONJ, there is currently no consensus on the ideal treatment protocol [ 6 ] or measurable effects of therapeutics. Recent studies show that adverse events still occur, and the incidence rate remains stable despite the harmful consequence of anti-resorptive drugs for patients [ 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Reporting Criteria for Clinical Trials on Medication-Related Osteonecrosis of the Jaw (MRONJ): A Review and Recommendations

Gaudet

Odet

Meyer

et al. 2022

Cells

View full text Add to dashboard Cite

Medication-related osteonecrosis of the jaw (MRONJ) is a complication caused by anti-resorptive agents and anti-angiogenesis drugs. Since we wanted to write a protocol for a randomized clinical trial (RCT), we reviewed the literature for the essential information needed to estimate the size of the active patient population and measure the effects of therapeutics. At the same time, we designed a questionnaire intended for clinicians to collect detailed information about their practices. Twelve essential criteria and seven additional items were identified and compiled from 43 selected articles. Some of these criteria were incorporated in the questionnaire coupled with data on clinical practices. Our review found extensive missing data and a lack of consensus. For example, the success rate often combined MRONJ stages, diseases, and drug treatments. The occurrence date and evaluation methods were not harmonized or quantitative enough. The primary and secondary endpoints, failure definition, and date coupled to bone measurements were not well established. This information is critical for writing a RCT protocol. With this review article, we aim to encourage authors to contribute all their findings in the field to bridge the current knowledge gap and provide a stronger database for the coming years.

show abstract