Epidemiology of Helicobacter pylori in Southern China: Identification of Early Childhood as the Critical Period for Acquisition

Mitchell, HazelM.; Li, Y Y; Hu, Pinjin; Liu, Q; Chen, M; Du, G G; Wang, Z J; Lee, A; Hazell, Stuart L.

doi:10.1093/infdis/166.1.149

Cited by 366 publications

(254 citation statements)

References 10 publications

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“…Between that age and up to 20, infection rate drops to 2.6% a year; after the age of 20, it decreases steadily and by 60 years of age it reaches 0.1% a year. These results are consistent with Mitchell et al 1 hypothesis that H. pylori infection in developing countries occurs mostly during childhood and that during adulthood the chance of getting infected is low but constant.…”

Section: Discussionsupporting

confidence: 93%

Prevalence of Helicobacter pylori infection in Fortaleza, Northeastern Brazil

et al. 2005

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The prevalence of Helicobacter pylori infection was assessed in a randomly selected sample of individuals from low-income community in Fortaleza, Northeastern Brazil. Overall, 384 out of 610 participants (62.9%) were H. pylori positive. A 47.5% infection rate was found in subjects aged six months to 10 years old, increased to 73.3% in subjects aged 11-20 years and then continued to increase with age reaching up to 87% in those over 60 years old. After this age group, the prevalence decreased slightly. The prevalence of infection increased significantly with age (p<0.0001).

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Section: Discussionsupporting

confidence: 93%

Prevalence of Helicobacter pylori infection in Fortaleza, Northeastern Brazil

et al. 2005

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“…3,9,94,104,116 Entretanto, nos países em desenvolvimento, a prevalência da infecção é mais alta em todas as faixas etárias. Essa diferença é mais acentuada na infância, como pode ser observada nas Figuras 1 e 2.…”

Section: Prevalência Relacionada à Idadeunclassified

“…18,41,47,49,62,88,90,94,108,118,141 Vale ressaltar que as variáveis relacionadas à alta densidade de habitantes na moradia estão intimamente interligadas, dificultando a determinação de qual poderia afetar diretamente a transmissão da bactéria.…”

Section: Número De Habitantes Por Cômodo Da Casaunclassified

“…8,27,30,78,94 Rothenbacher et al 119 estudaram a prevalência do H. pylori em 1.143 crianças e seus respectivos acompanhantes (n=1.074) mediante teste respiratório com C 13 -uréia. Os autores concluíram que pais infectados, especialmente as mães, podem desempenhar importante papel na transmissão do H. pylori entre familiares, à semelhança do que se observa em relação a outras bactérias da cavidade oral, como é o caso do Streptococcus mutans.…”

Section: Unidade Familiarunclassified

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Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

2002

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Descritores ResumoRealizou-se revisão da epidemiologia da infecção pelo Helicobacter pylori, com o objetivo de analisar sua importância na infância e adolescência no que se refere à incidência, à prevalência, às vias de transmissão e aos fatores de risco. Para tanto, realizou-se uma pesquisa nas bases de dados Lilacs (OPS/Bireme) e Medline (National Library of Medicine) e no banco de teses da Universidade de São Paulo dos anos de 1983 a 1999. A análise da literatura levou à conclusão de que a infecção pelo Helicobacter pylori é adquirida principalmente durante a infância, apresenta aumento da prevalência com a idade, os principais fatores de riscos estão relacionados ao baixo nível socioeconômico e o mecanismo de transmissão permanece desconhecido. AbstractThe scope of the review is to study the epidemiological aspects of Helicobacter pylori infection and its importance during childhood and adolescence, focusing on incidence, prevalence, transmission and risk factors. The study's references included the following databases: LILACS (PAHO/ Bireme), MEDLINE, the US's National Library of Medicine and the thesis developed at University of São Paulo for the period 1983 to 1999. It was noted that Helicobacter pylori infection is mainly acquired during childhood, age-related prevalence, main risk factors are associated to low socioeconomic status, and its transmission mechanism remains unclear.

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“…8 Studies in the United States indicated that infection of children with H. pylori increases with age. [9][10][11][12] Older children had the same positive rate of antibody positivity to H. pylori as adults. 13 Furthermore, the prevalence of H. pylori infection in developing countries was higher, possibly due to the poorer socioeconomic conditions and crowding.…”

mentioning

confidence: 93%

Seroepidemiology of Helicobacter pylori infection among preschool children in Taiwan.

Lin¹,

Nieh²,

Wang³

et al. 1999

The American Journal of Tropical Medicine and Hygiene

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Abstract. Helicobacter pylori is associated with chronic antral gastritis that is related to duodenal ulcer, gastric ulcer, and probably gastric adenocarcinoma. Infection with H. pylori during childhood is considered an important risk factor for gastric carcinoma in adult life. To examine the epidemiologic characteristics of H. pylori infection among preschool children in central Taiwan, a community-based survey was carried out in 54 kindergartens in 10 urban townships, 10 metropolitan precincts, and 2 aboriginal townships randomly selected through stratified sampling. Serum specimens of 2,551 healthy preschool children (3-6 years old) randomly sampled from study kindergartens were screened for antibodies to H. pylori by latex agglutination and ELISA methods. Multivariate-adjusted odds ratios (ORs) with their 95% confidence intervals (CIs) were estimated by multiple logistic regression analysis. A total of 207 subjects were antibody-positive, giving a prevalence of 8.1%. The overall seropositive rates were 4.5% in 3-year-old group, 4.4% in 4-year-old group, 9.4% in 5-year-old group, and 11.7% in 6-year-old group. The older the age, the higher the seroprevalence (OR ϭ 3.2, 95% CI ϭ 1.5-6.8 for 3-year-old children versus the 6-year-old children). Seroprevalence was not different between boys and girls. The aboriginal townships had a seroprevalence greater than the urban townships and metropolitan precincts (OR ϭ 2.6, 95% CI ϭ 1.9-3.7). The larger the number of siblings, the higher the seroprevalence (OR ϭ 2.4, 95% CI ϭ 1.0-5.8 for those with no sibling versus those with Ն 3 siblings). In the multiple logistic regression analysis, the seroprevalence of H. pylori remained significantly increased with age, aboriginal township, and large sibship size after multivariate adjustment. A poor water supply system, sewage disposal, and other environmental hygiene in the aboriginal townships might have played some role in infection with H. pylori. The early childhood transmission among siblings might also be an important determinant of H. pylori seropositivity in Taiwan.Infection with Helicobacter pylori has been causally related to chronic gastritis and peptic ulcer, and indirectly related to gastric adenocarcinoma and primary gastric B cell lymphoma.

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Epidemiology of Helicobacter pylori in Southern China: Identification of Early Childhood as the Critical Period for Acquisition

Cited by 366 publications

References 10 publications

Prevalence of Helicobacter pylori infection in Fortaleza, Northeastern Brazil

Prevalence of Helicobacter pylori infection in Fortaleza, Northeastern Brazil

Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

Seroepidemiology of Helicobacter pylori infection among preschool children in Taiwan.

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