Epidemiology of Gastric Cancer in Kazakhstan in 2005-2014

Zhandossov, O.; Каусова, Г К; Emberdiyev, A. Z.; Lurye, A. Z.; Ivanov, Sergey V.; Дубовиченко, Д. М.; Grjibovski, A. M.

doi:10.33396/1728-0869-2017-6-50-57

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…Khromtau is considered a heavily polluted district of the Aktobe region, Republic of Kazakhstan, as indicated by the number of people's visits to hospitals (seven times a year). This district contains chrome industry enterprises whose chemicals negatively affect the health of the population (Zhandosov et al, 2018; Table 1).…”

Section: Environmental Pollution and Health Impacts In The Aktobe Regionmentioning

confidence: 99%

The influence of environmental factors on the health of the population of the Aktobe region

Moldayazova,

Zhapalakov,

Shagatayeva

et al. 2023

Integr Envir Assess & Manag

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This study investigates the impact of environmental factors on human health, including harmful substances, extreme temperatures, and air quality. The health status of the population in regions where many industries operate also depends on meteorological factors. The purpose of the study is to characterize and determine the influence of environmental factors (humidity, temperature, wind) and industries, including metal mining and processing regions, on the health of people in the Aktobe region, Republic of Kazakhstan. The study used general theoretical methods to analyze and systematize the results of the meteorological service of the Aktobe region and the experiments conducted by the branch of the National Centre of Expertise of the Committee of Sanitary and Epidemiological Control of the Ministry of Healthcare of the Republic of Kazakhstan for the Aktobe region in 2020 and 2021. Statistical data on the amount of chromium, lead, and nickel in the blood, and the morbidity rate of the population were analyzed. The study's findings indicate that residents in the Aktobe region experience hypothermia during winter at temperatures between −12 °C and −15 °C and humidity of 81%, and in summer overheating occurs at temperatures between +19.6 °C and +22.5 °C with humidity of 77%. These extreme temperature conditions disrupt the body's heat exchange with the environment, affecting the respiratory and circulatory systems. Moreover, the predominantly windless conditions in the region affect the atmosphere's self‐cleaning ability, resulting in high levels of air pollution throughout the year. The findings can inform strategies to improve public health and prevent diseases in industrial regions. Integr Environ Assess Manag 2023;00:1–10. © 2023 SETAC

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Section: Environmental Pollution and Health Impacts In The Aktobe Regionmentioning

confidence: 99%

The influence of environmental factors on the health of the population of the Aktobe region

Moldayazova,

Zhapalakov,

Shagatayeva

et al. 2023

Integr Envir Assess & Manag

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“…The Kazakhstan’s age-standardized rate of GC in 2018 was 15.7 per 100,000, which was outnumbered in Asia only by South Korea, Mongolia, Japan, and China (39.6, 33.1, 27.5, and 20.7 respectively). Approximately 16.8% to 34.2% of GC is detected at an early stage in Kazakhstan [ 1 ]. The quality of endoscopy and monitoring of patients with precancerous lesions (atrophy, intestinal metaplasia, and dysplasia) are prerequisites for early detection of cancer.…”

Section: Introductionmentioning

confidence: 99%

Association of polymorphisms in TP53 and the promoter region of IL10 with gastric cancer in a Kazakh population

Kulmambetova¹,

Shtefanov²,

Aitkulova³

et al. 2020

Bosn J of Basic Med Sci

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The emerging evidence indicates that single nucleotide polymorphisms (SNPs) of the TNF, IL10, TP53, and CD14 genes may determine individual susceptibility to gastric cancer. We aimed to investigate the associations for polymorphisms of the TNF, IL10, TP53, and CD14 genes in a population of Kazakhs, to identify potential risk or protective associations of the SNPs with gastric cancer. A case group of 143 patients hospitalized for gastric cancer was enrolled. Controls were 355 volunteers with no history of any cancer and frequency matched with cases by age. Differences in proportions for categorical variables and the assessment of genotypic frequencies conforming to the Hardy–Weinberg equilibrium law were evaluated by the chi-square test. Associations between genetic polymorphisms and the risk of gastric cancer were estimated by regression analysis. For genetic analysis, three genetic models (additive, dominant, and recessive) were used. Four significant associations were found. The SNPs rs1042522 of TP53 and rs1800896 of IL10 were risk factors for gastric cancer by the additive model. Two polymorphisms of IL10 were protective of gastric cancer, namely, rs1800872 by additive model and rs1800871 by recessive model. No signiﬁcant associations were observed between TNF and CD14 polymorphisms and gastric cancer. The polymorphisms TP53 rs1042522 and IL10 rs1800896 are associated with gastric cancer risk, while the polymorphisms IL10 rs1800872 and rs1800871 are protective of gastric cancer in the population of Kazakhs.

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Epidemiology of Gastric Cancer in Kazakhstan in 2005-2014

Cited by 2 publications

References 20 publications

The influence of environmental factors on the health of the population of the Aktobe region

The influence of environmental factors on the health of the population of the Aktobe region

Association of polymorphisms in TP53 and the promoter region of IL10 with gastric cancer in a Kazakh population

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