Epidemiology of early-onset dementia: a review of the literature

Vieira, Renata Teles; Caixeta, Leonardo; Machado, Sérgio; Silva, Adriana Cardoso; Nardi, Antônio Egídio; Arias-Carrión, Óscar; Carta, Mauro Giovanni

doi:10.2174/1745017901309010088

Cited by 246 publications

(168 citation statements)

References 64 publications

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“…The subtypes in YOD appear to be more heterogeneous than in LOD. AD is, however, still the most common cause of dementia also in young adults (Vieira et al, 2013). Frontotemporal dementia (FTD) accounts for a larger proportion of the cases in YOD compared to LOD (Harvey et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Determinants of quality of life in young onset dementia – results from a European multicenter assessment

Millenaar

Hvidsten

Vugt

et al. 2016

Aging & Mental Health

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Background: Promoting adaptation, improving well-being and maintaining an optimal quality of life (QOL) is an important aspect in dementia care. The purpose of this study was to identify determinants of QOL in young onset dementia, and to assess differences in QoL domains between people with Alzheimer's disease (AD) and frontotemporal dementia (FTD). Methods: In total 135 persons with AD and 58 persons with FTD were included from two prospective cohort studies. QOL was assessed with the proxy reported quality of life in Alzheimer's disease questionnaire (QoL-AD). Possible determinants were explored using multiple linear regression and included sociodemographic variables, diagnosis, dementia severity, disease awareness, neuropsychiatric symptoms, met and unmet needs and hours of personal and instrumental care. Differences between QOL domains in people with AD and FTD were calculated using Mann-Whitney U tests. Results: Lower QOL was associated with more depressive symptoms, lower disease awareness, and a higher amount of needs, both met and unmet. People with AD scored lower on the memory and higher on the friends' subscale. No differences were found for the other items. Conclusion: This study demonstrates a unique set of determinants of QOL in AD and FTD. Interventions directed towards these specific factors may improve QOL.

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Section: Introductionmentioning

confidence: 99%

Determinants of quality of life in young onset dementia – results from a European multicenter assessment

Millenaar

Hvidsten

Vugt

et al. 2016

Aging & Mental Health

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“…While it is still poorly understood, Alzheimer's disease is the major etiology, followed by vascular dementia, and Frontotemporal Lobar Degeneration (Vieira et al 2013). However, causes of presenile dementia can also include other neurodegenerative dementia, other vascular diseases, infectious disease, inflammatory and autoimmune disease, or neurometabolic disease.…”

Section: Definitionmentioning

confidence: 99%

Presenile Dementia

Zichlin

2017

Encyclopedia of Clinical Neuropsychology

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“…The diagnosis of young-onset dementia, showing a highly variable epidemiology [210], presents challenges that differ from those of older patient frequently driven by the identification of genetic mutations causing early-onset familial disease [211]. However, despite absence of absolute concordance between clinical phenotype and underlying pathology, they can be distinguished with high accuracy.…”

Section: Rapidly Progressive and Early Onset Dementiasmentioning

confidence: 99%

Neuropathology of Dementia Disorders

Jellinger¹

2014

J Alzheimers Dis Parkinsonism

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IntroductionDementia, encompassing deficits in several cognitive domains that are severe enough to interfere with daily functioning [1], in the new DSM V classification is classified within the broad category of major neurocognitive disorders, proposing specific criteria for the various etiologies [2]. Previously defined as the manifestation of deteriorating brain functions over time due to cell deaths in the brain caused by neurodegeneration or any other disease [3], according to recent research dementia is not primarily caused by neuronal cell death/loss, but by dysfunction and loss of synapses [4] in AD [5] and in α-synucleinopathies [6]. Other causes include cholinergic neuronal and axonal abnormalities [7,8], as well as pre-and postsynaptic cortical cholinergic deficits also occurring in early AD [9]. These changes due to disconnection of major nervous circuitries causing default networks [10][11][12][13] have been demonstrated in vivo in early AD [14], suggesting that disease progress is transmitted by neuronal pathways [15]. A prionlike spread of misfolded protein aggregates in the pathogenesis and progression of neurodegeneration is a hot spot of discussion [16][17][18][19][20][21].Both the prevalence and incidence of dementia increase exponentially with age. In 2010, 35.6 million people worldwide lived with dementia, with around 8 million new cases every year. Numbers are expected to double or triple every 5-10 years, to 135 millions in 2050, 16 millions in Europe. In 2010, 58% of all demented people lived in low-cost countries, with their proportion anticipated to rise to 71% in 2050 [22]. According to recent data from China the incidence of dementia was 9.87/1000 person years and the median standardised mortality ratio was 1.94:1 [23]. With the disproportional growth of the elderly population, dementia has become a major public health and socio-economic problem that threatens to become the scourge of our century. The total costs for dementia were US$ 604 billion in 2010 worldwide, up to 70% for social care alone [24], total payments for AD for 2013 were expected to be $ 203 billion in USA alone, not included contributions of unpaid caregivers [25]. Neuropathology of Dementia DisordersKurt A Jellinger* Institute of Clinical Neurobiology, Kenyongasse 18, A 1070, Vienna, Austria AbstractDementia, being not a specific disease but a syndrome characterized by deficits in several cognitive domains, is a major public health and socio-economic problem of our century. It is caused by dysfunction/loss of synapses and neurons inducing default neuronal networks. Despite updated concensus criteria for the clinical diagnosis of the major neurodegenerative disorders and new biomarkers, the diagnostic accuracy ranges from 65 to 96% (for Alzheimer's disease /AD), with a sensitivity versus other dementias of around 85.4% and a specificity of up to 77.7%. Pathologic assessment, using genetic and molecular biological methods, based on homogenous definitions, harmonized interlaboratory and assessment standards, can achiev...

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Epidemiology of early-onset dementia: a review of the literature

Cited by 246 publications

References 64 publications

Determinants of quality of life in young onset dementia – results from a European multicenter assessment

Determinants of quality of life in young onset dementia – results from a European multicenter assessment

Presenile Dementia

Neuropathology of Dementia Disorders

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