Epidemiology of cholelithiasis in southern Italy. Part II

Misciagna, Giovanni; Leoci, Claudio; Guerra, Vito; Chiloiro, Marisa; Elba, Silvana; Petruzzi, Josè; Mossa, Ascanio; Noviello, M. R.; Coviello, Angelo; Minutolo, Marino Capece; Mangini, V; Messa, Caterina; Cavallini, A; Michele, Giampiero De; Giorgio, I

doi:10.1097/00042737-199606000-00017

Cited by 110 publications

(80 citation statements)

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“…Böylece kolesterol taşı nü-vesi oluşmakta veya oluşan nüveler üzerinde kolesterol ve safra asitleri tabakası artmaktadır [11]. Hiperglisemi safra kesesi motilitesini etkilediği gibi kolelitiazis oluşumunu ve safra kesesi mukus sekresyonunu da etkilemektedir [19][20]. Sadece karaciğere spesifik insülin reseptörleri inhibe edilerek izole insü-lin rezistansı oluşturulmuş LIRKO (Liver insulin receptor knockout) fareleri ile yapılan hayvan çalışmalarında litojenik diyet ile beslenen hayvanların %36'sında bir hafta sonra safra taşı oluşurken, 12 hafta sonra tüm farelerde safra taşı oluşmuştur [21].…”

Section: Discussionunclassified

The Effect of Obesity on Co-Existence of Umbilical Hernia and Metabolic Syndrome in Patients with Cholelithiasis

2016

Ann Clin Anal Med

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ÖzetAmaç: Çalışmamızın amacı popülasyonda sık görülen kolelitiazis (safra kesesi taşı), umbilikal herni (UH) ve metabolik sendrom (MS) hastalığının beraber bulunma oranlarını incelemek, kilo ve kolesterol yüksekliklerinin belirtilen hastalıkların bulunma oranlarını değiştirip değiştirmeyeceğini gözlemle- Anahtar KelimelerSafra Kesesi Taşı; Metabolik Sendrom; Umblikal Herni Abstract Aim: The aim of our study is to assess the co-existence ratios of cholelithiasis, umbilical hernia (UH) and metabolic syndrome (MS), which are commonly seen in population, and also is to research whether high cholesterol levels and body weight can change the co-existence ratio of these illnesses. Material and Method: Data of patients who underwent laparoscopic cholecystectomy (LC) due to cholelithiasis in our clinic were retrospectively reviewed. Patients were divided into three groups according to body mass index (BMI) criteria defined by the World Health Organization (WHO). Moreover, patients were divided into two groups as patients with high and normal cholesterol levels according to the third version of the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP-III). The prevalence of metabolic syndrome and umbilical hernia were investigated in the groups. Results: Of the 78 patients included in the study, 11 (14.1%) patients were detected to have umbilical hernia, 39 (50%) patients were detected to have metabolic syndrome. Co-existence of the metabolic syndrome and umbilical hernia were detected in 8 (10.2%) patients. When patients were classified according to body mass index, 23 patients were detected as normal weight, 41 patients as overweight and 14 patients as obese. According to these groups, distribution of patients was determined to be 1 (4.3%), 5 (12.2%) and 5 (35.7%) patients for UH (p = 0.026), 6 (26.1%), 22 (53%) and 11 (78.6%) patients for MS (p = 0.007), 1 (4.3%), 2 (4.8%) and 5 (35.7%) patients for MS+UH (p = 0.002), respectively, and statistically significant differences were determined among groups. Discussion: We can say that both many postoperative complications and perioperative complications resulting from frequency of UH have increased in high BMI with patients among planned laparoscopic cholecystectomy operation due to cholelithiasis. Likewise, it can be said that MS is a risk factor for formation of gallstone in patients with both cholelithiasis and high BMI. Co-existence of UH and MS has increased in patients with both cholelithiasis and high BMI, but it should be supported with extensive case studies.

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Section: Discussionunclassified

The Effect of Obesity on Co-Existence of Umbilical Hernia and Metabolic Syndrome in Patients with Cholelithiasis

2016

Ann Clin Anal Med

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“…Supersaturated bile in the gallbladder induces cholelithiasis in diabetic subjects [21] . The association of diabetics with GSD is stronger in subjects with a history of treated diabetes mellitus than in those with a simple history of diabetes and this could be an effect of hyperglycemia on gallbladder motility [22] . Furthermore, diabetes mellitus combined with GSD may induce acute cholecystitis more frequently and have a higher possibility of progression to septicemia [7] .…”

Section: Prevalence Of Gallstone Disease In the General Populationmentioning

confidence: 94%

Clinical correlation of gallstone disease in a Chinese population in Taiwan: Experience at Cheng Hsin General Hospital

Liu¹,

Tung²,

Chou³

et al. 2006

WJG

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INTRODUCTIONGallstone disease (GSD) is one of the most common diseases in developed countries. Recent studies indicate varying prevalence of GSD with several predisposing factors in different study populations [1][2][3][4][5][6][7][8][9] . From a medical economic perspective, the direct and indirect costs of treating GSD patients were estimated at $16 billion and account for more than 800 000 hospitalizations yearly in the United States [9,10] . In Taiwan, the prevalence of GSD in the general population was 4.3% in 1989 [8] while another voluntary screening revealed that the prevalence of GSD was 10.7% among healthy subjects in 1995 [2] . For this reason, due to westernization of the diet and the environment, GSD is not rare in the Chinese population and has become one of the major health problems in Taiwan [7] . Without an appropriate and effective screening program for symptomatic GSD, the medical treatment of GSD and related complications contributes substantially to health care costs.From the viewpoint of preventive medicine, it is RAPID COMMUNICATION RESULTS:The overall prevalence of GSD among this study-population was 5.3%, including 1.7% (n = 40) having a single stone, 2.3% (n = 55) having multiple stones, and 1.3% (n = 31) having cholecystectomy. The prevalence revealed a statistically significant increase with increasing age (P < 0.0001). Females exhibited a greater prevalence of multiple stones than did males (3.0% vs 1.7%, P = 0.04). Using multiple logistic regression analysis, the following appeared to be significantly related to the prevalence of GSD: older

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“…Although population surveys using oral cholecystography and, more recently, ultrasonography have been performed in various populations, they generally do not provide information on time trends. [3][4][5] Therefore, data on hospital admissions and operations are valuable in assessing time trends in gallstone disease. They also provide information on the impact of gallstone disease on hospital services and data for the planning of health services.…”

Section: Introductionmentioning

confidence: 99%

Gallstones — an increasing problem: a study of hospital admissions in England between 1989/1990 and 1999/2000

Kang

Ellis

Majeed

et al. 2003

Aliment Pharmacol Ther

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SUMMARYBackground: The number of operations for cholelithiasis increased from the 1950s to the 1990s. Aims: To determine the time trends in cholelithiasis for hospital admissions, operations and in-hospital case fatalities in England between 1989 ⁄ 1990 and 1999 ⁄ 2000, and population mortality rates between 1979 and 1999. Methods: Hospital Episode Statistics for admissions were obtained from the Department of Health and mortality data were obtained from the Office for National Statistics. Results: Between 1989 ⁄ 1990 and 1999 ⁄ 2000, agestandardized hospital admission rates for cholelithiasis increased by 30% for males and 64% for females. The

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Epidemiology of cholelithiasis in southern Italy. Part II

Cited by 110 publications

References 0 publications

The Effect of Obesity on Co-Existence of Umbilical Hernia and Metabolic Syndrome in Patients with Cholelithiasis

The Effect of Obesity on Co-Existence of Umbilical Hernia and Metabolic Syndrome in Patients with Cholelithiasis

Clinical correlation of gallstone disease in a Chinese population in Taiwan: Experience at Cheng Hsin General Hospital

Gallstones — an increasing problem: a study of hospital admissions in England between 1989/1990 and 1999/2000

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