Epidemiology of basal cell carcinoma in the United Kingdom: incidence, lifestyle factors, and comorbidities

Abstract

Background:Little is known about the epidemiology of basal cell carcinoma (BCC).Methods:Using the Clinical Practice Research Datalink, we calculated annual incidence rates. In a case–control analysis, we examined lifestyle factors and comorbidities.Results:Incidence rose significantly between 2000 and 2011. Basal cell carcinoma risk was increased in alcohol drinkers (slightly) and immunocompromised patients, but reduced in smokers and individuals with abnormal weight.Conclusions:Basal cell carcinoma places a growing public health burden. Lifestyle factors do not play a major role in pathogenesis, but immunosuppression is important.

Alcohol intake and risk of nonmelanoma skin cancer: a systematic review and dose–response meta‐analysis

“…As a result, many were limited by broad definitions of alcohol intake (such as ‘drinker’ vs. ‘nondrinker’) and were rated as lower quality by our assessment criteria. Only one large case–control study by Reinau et al . (57 121 BCC cases) found that current alcohol drinkers had a significant but modest increase in BCC risk compared with nondrinkers.…”

“…One meta‐analysis found no association between alcohol consumption and risk of BCC . Since then, recent studies have reported a positive association for BCC, cSCC and NMSC . This systematic review and meta‐analysis quantifies the association between alcohol intake and NMSC risk.…”

“…Additionally, acetaldehyde is an ethanol metabolite that can interfere with DNA synthesis and repair, leading to carcinogenicity . Although several epidemiological studies have investigated the relationship between alcohol intake and NMSC risk, the results were largely null. One meta‐analysis found no association between alcohol consumption and risk of BCC .…”

Chronic Pruritus in the Elderly: Pathophysiology, Diagnosis and Management

“…Basal cell carcinoma (BCC) is the most common type of malignancy in humans and the most common skin cancer in the elderly [84]. Although itch has not often been mentioned as a common symptom, a recent large study found that 32 % of patients with BCC had itch.…”

Association of Shiny White Blotches and Strands With Nonpigmented Basal Cell Carcinoma

“…1–4 In the United States, age-adjusted BCC incidence rates have doubled over the past 2 decades, with recent estimates of 1019 cases per 100000 person-years for women and 1488 cases per 100000 person-years for men. 5 Although it rarely metastasizes, BCC can cause significant local tissue destruction and cosmetic impairment, making treatment options challenging in advanced stages.…”