Epidemiology and molecular identification of mycoplasma pneumoniae associated with respiratory infections in Zhejiang province, China, 2008‐2017

Jiang, Qian; Yang, Fangfang; Peng, Yumeng; Dong, Xiaoyan

doi:10.1002/jcla.23460

Cited by 7 publications

(10 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the positive rate of MP was detected more commonly in children 3 years of age or older than in younger children, which was corroborated by previous epidemiological studies ( Jain et al., 2015 ; Schildgen et al., 2018 ; Liu et al., 2020 ). However, the positive rate of MP in our study is different from that in other previous studies ( Gao LW et al., 2019 ; Jiang et al., 2020 ), which may be due to differences in MP detection methods and enrolled populations. Chemiluminescence was used to detect IgM antibodies of serum MP in our study, whereas atypical pathogen DNA was detected in nasopharyngeal samples by a polymerase chain reaction in some studies ( Del Valle-Mendoza et al., 2017 ; Jiang et al., 2020 ; Kumar et al., 2020 ), or MP antibody was detected by the passive agglutination method ( Gao CH et al., 2019 ; Gao LW et al., 2019 ).…”

Section: Discussioncontrasting

confidence: 99%

“…However, the positive rate of MP in our study is different from that in other previous studies ( Gao LW et al., 2019 ; Jiang et al., 2020 ), which may be due to differences in MP detection methods and enrolled populations. Chemiluminescence was used to detect IgM antibodies of serum MP in our study, whereas atypical pathogen DNA was detected in nasopharyngeal samples by a polymerase chain reaction in some studies ( Del Valle-Mendoza et al., 2017 ; Jiang et al., 2020 ; Kumar et al., 2020 ), or MP antibody was detected by the passive agglutination method ( Gao CH et al., 2019 ; Gao LW et al., 2019 ). PCR-based techniques are now considered more reliable, however, this method also has limitations, such as low sensitivity and positive predictive values ( Nilsson et al., 2008 ; Chang et al 2014 ; Kurkela et al 2019 ).…”

Section: Discussioncontrasting

confidence: 99%

See 1 more Smart Citation

Epidemiological Study on Mycoplasma pneumoniae and Chlamydia pneumoniae Infection of Hospitalized Children in a Single Center During the COVID-19 Pandemic

Cai

Shou²,

Ye³

2022

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

BackgroundSince the outbreak of COVID-19, a series of preventive and control measures in China have been used to effectively curb the spread of COVID-19. This study aimed to analyze the epidemiological characteristics of Mycoplasma pneumoniae (MP) and Chlamydia pneumoniae (CP) in hospitalized children with acute respiratory tract infection during the COVID-19 pandemic.MethodsMP IgM antibody and CP IgM antibody were detected in all hospitalized children due to acute respiratory tract infection in the Children’s Hospital Affiliated to Zhejiang University from January 2019 to December 2020. These data were compared between 2019 and 2020 based on age and month.ResultsThe overall detection rate of MP and CP in 2020 was significantly lower than that in 2019 (MP: 21.5% vs 32.9%, P<0.001; CP: 0.3% vs 0.9%, P<0.001). This study found a 4-fold reduction in the number of children positive for MP and a 7.5-fold reduction in the number of children positive for CP from 2019 to 2020. The positive cases were concentrated in children aged >1 year old. In 2019, the positive rate of MP was detected more commonly in children 3 years of age or older than in younger children. In 2020, the higher positive rate of MP reached a peak in the 3- to 6-year age group (35.3%). CP was detected predominantly in children aged 6 years older in 2019 and 2020, with positive rates of 4.8% and 2.6%, respectively. Meanwhile, the positive rates of MP in 2019 were detected more commonly in July, August and September, with 47.2%, 46.7% and 46.3%, respectively. Nevertheless, the positive rates of MP from February to December 2020 apparently decreased compared to those in 2019. The positive rates of CP were evenly distributed throughout the year, with 0.5%-1.6% in 2019 and 0.0%-2.1% in 2020.ConclusionsA series of preventive and control measures for SARS-CoV-2 during the COVID-19 pandemic can not only contain the spread of SARS-CoV-2 but also sharply improve the infection of other atypical pathogens, including MP and CP.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Epidemiological Study on Mycoplasma pneumoniae and Chlamydia pneumoniae Infection of Hospitalized Children in a Single Center During the COVID-19 Pandemic

Cai

Shou²,

Ye³

2022

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Although substantial numbers of children were diagnosed with M. pneumoniae infection throughout the study period, the epidemic peaked in the fourth quarter of each year between 2017 and 2019, which was consistent with the results obtained previously in South Korea [2,17], USA [3], Israel, and 11 countries of Europe [16]. However, the tendencies in these studies differ from the data reported in epidemiological studies in Italy [18], South Africa [19], and other regions of China [8,20,21]. The peaks of M. pneumoniae infection between 2017 and 2019 in our study coincided with the school semesters, and the number of infections fell significantly after schools were closed to limit the COVID-19 pandemic.…”

Section: Discussionsupporting

confidence: 89%

Effect of COVID-19 on childhood Mycoplasma pneumoniae infection in Chengdu, China

Zhang

Huang

et al. 2021

BMC Pediatr

View full text Add to dashboard Cite

Background Following the outbreak of the COVID-19 pandemic, a change in the incidence and transmission of respiratory pathogens was observed. Here, we retrospectively analyzed the impact of COVID-19 on the epidemiologic characteristics of Mycoplasma pneumoniae infection among children in Chengdu, one of the largest cities of western China. Method M. pneumoniae infection was diagnosed in 33,345 pediatric patients with respiratory symptoms at the Chengdu Women’s & Children’s Central Hospital between January 2017 and December 2020, based on a serum antibody titer of ≥1:160 measured by the passive agglutination assay. Differences in infection rates were examined by sex, age, and temporal distribution. Results Two epidemic outbreaks occurred between October-December 2017 and April-December 2019, and two infection peaks were detected in the second and fourth quarters of 2017, 2018, and 2019. Due to the public health response to COVID-19, the number of positive M. pneumoniae cases significantly decreased in the second quarter of 2020. The number of M. pneumoniae infection among children aged 3–6 years was higher than that in other age groups. Conclusions Preschool children are more susceptible to M. pneumoniae infection and close contact appears to be the predominant factor favoring pathogen transmission. The public health response to COVID-19 can effectively control the transmission of M. pneumoniae.

show abstract

“…This may be related to the different epidemiological characteristics of the different respiratory pathogens in each region. From a single pathogen perspective, the high prevalence of with HBoV mixed with MP and HRV in this study may be related to the high prevalence of MP and HRV in summer and autumn in China ( 20 , 21 ).…”

Section: Discussionmentioning

confidence: 81%

Comparison of the clinical features of human bocavirus and metapneumovirus lower respiratory tract infections in hospitalized children in Suzhou, China

et al. 2023

View full text Add to dashboard Cite

ObjectiveWe compared the clinical data of hospitalized children with lower respiratory tract infections caused by human bocavirus (HBoV) and human metapneumovirus (hMPV).MethodsIn total, 8,430 children admitted to the Department of Respiration, Children's Hospital of Soochow University for lower respiratory tract infections from January 2017 to October 2021 were enrolled. Seven common respiratory viruses, including respiratory syncytial virus, influenza virus A, influenza virus B, parainfluenza virus (PIV) I, PIV II, PIV III, and adenovirus, were detected by direct immunofluorescence assay, whereas human rhinovirus and hMPV were detected by reverse transcription-polymerase chain reaction. Mycoplasma pneumoniae (MP) and HBoV were detected by real-time fluorescence quantitative polymerase chain reaction. Bacteria was detected in blood, nasopharyngeal secretion, bronchoalveolar lavage specimen or pleural fluid by culture. In parallel, MP was detected by enzyme-linked immunosorbent assay. In addition, we performed metagenomic testing of alveolar lavage fluid from some of the patients in our study.ResultsThe detection rate of HBoV was 6.62% (558/8430), whereas that of hMPV was 2.24% (189/ 8430). The detection rate of HBoV was significantly higher in children aged 1 to <3 years than in other age groups, but there were no significant differences in positivity rates for hMPV by age. Before 2020, the incidence of HBoV infection peaked in summer and autumn, whereas that of hMPV peaked in spring. The epidemiology of both HBoV and hMPV has changed because of the impact of the novel coronavirus. Among the positive cases, the HBoV mixed infection rate was 51.6%, which was similar to that for hMPV mixed infection (44.4%). Comparing clinical characteristics between HBoV and hMPV single infection, the median age of children was 17 months in the HBoV group and 11 months in the hMPV group. In the HBoV single infection group, 31 patients (11.5%) had pulse oxygen saturation of less than 92% on admission, 47 (17.4%) had shortness of breath, and 26 (9.6%) presented with dyspnea. Meanwhile, four patients (3.8%) in the hMPV single infection group had pulse oxygen saturation of less than 92% on admission, eight (7.6%) displayed shortness of breath, and three (2.9%) had dyspnea. The proportion of patients requiring mechanical ventilation and the rate of PICU admission were higher in the HBoV group than in the hMPV group.ConclusionThe prevalence of HBoV infection is higher than that of hMPV infection in children with lower respiratory tract infection in Suzhou, and HBoV is more likely to cause severe infection than hMPV. Public health interventions for COVID-19 outbreaks have affected the prevalence of HBoV and hMPV.

show abstract

Epidemiology and molecular identification of mycoplasma pneumoniae associated with respiratory infections in Zhejiang province, China, 2008‐2017

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 7 publications

References 24 publications

Epidemiological Study on Mycoplasma pneumoniae and Chlamydia pneumoniae Infection of Hospitalized Children in a Single Center During the COVID-19 Pandemic

Epidemiological Study on Mycoplasma pneumoniae and Chlamydia pneumoniae Infection of Hospitalized Children in a Single Center During the COVID-19 Pandemic

Effect of COVID-19 on childhood Mycoplasma pneumoniae infection in Chengdu, China

Comparison of the clinical features of human bocavirus and metapneumovirus lower respiratory tract infections in hospitalized children in Suzhou, China

Contact Info

Product

Resources

About