Epidemiology and Clinical Outcomes of Acute Spine Trauma and Spinal Cord Injury: Experience From a Specialized Spine Trauma Center in Canada in Comparison With a Large National Registry

Kattail, Deepa; Furlan, Julio C.; Fehlings, Michael G.

doi:10.1097/ta.0b013e3181a8b431

Cited by 85 publications

(71 citation statements)

References 31 publications

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“…In a specialized trauma center in Canada 17 , as well as in evaluations conducted in the eastern zone São Paulo city (Brazil) 18 it has been observed an increased prevalence of SCI in women, to about 30%. These data can be directly related to the fact that the women are carrying more vehicles (motorcycles, cars), as well as being professionally more inserted in civilian buildings, where falls are more frequent.…”

Section: Discussion Discussion Discussion Discussion Discussionmentioning

confidence: 99%

Avaliação epidemiológica dos pacientes vítimas de traumatismo raquimedular

Brito¹,

Chein²,

Marinho³

et al. 2011

Rev. Col. Bras. Cir.

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OBJETIVO: Fazer avaliação epidemiológica de 87 pacientes vítimas de traumatismo da medula espinhal, internados no hospital universitário da UFMA entre Janeiro de 2008 e Junho de 2009. MÉTODOS: Estudo transversal retrospectivo, segundo: sexo; idade; segmento da coluna comprometido e causa do traumatismo, submetendo estes dados à análise estatística (teste do quiquadrado). RESULTADOS: predomínio significativo (p<0,001) do sexo masculino, com 81,6% (71) dos casos, e da faixa etária entre 21 e 30 anos de idade (p<0,001), com 39,1% (34) dos casos. A média de idade foi 33,96±13,56 anos. A proporção de quedas de altura foi significativamente maior do que a dos acidentes automobilísticos (p<0,001) e motociclísticos (p<0,001). O segmento da coluna significativamente (p<0,001) mais comprometido foi o torácico 37,9% (33) dos casos. Os acidentes de trânsito aparecem em maior proporção entre os homens (p=0,014). A coluna cervical foi mais acometida no sexo masculino (p=0,043). As fraturas toracolombares foram provocadas, em maior proporção, pelas quedas de altura (p=0,003), enquanto que acometimento da coluna torácica é significativamente maior (p=0,016) nos acidentes de trânsito. CONCLUSÃO: o grupo de maior risco para o traumatismo da coluna espinhal é o de adultos jovens masculinos. Apesar de existir uma diferença entre os sexos quando se correlacionam os acidentes de trânsito, a queda de altura é a principal causa em ambos os sexos.

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Section: Discussion Discussion Discussion Discussion Discussionmentioning

confidence: 99%

Avaliação epidemiológica dos pacientes vítimas de traumatismo raquimedular

Brito¹,

Chein²,

Marinho³

et al. 2011

Rev. Col. Bras. Cir.

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“…12 Another study conducted in Canada showed that injuries due to falls cause lesions mainly at the cervical, low thoracic and lumbar levels. 4 As reported in a previous study in our centre, diving is the most common cause among sports and leisure accidents affecting young persons and resulting in the majority of neurologically incomplete cervical SCI cases 13 according to the American Spinal Injury Association-International Spinal Cord Society international standard for neurological classification. 14 Other causes, such as violence and gunshots, are not common in Europe and in Italy when compared with South America and USA.…”

Section: Introductionmentioning

confidence: 97%

“…There is a strong male predominance. [1][2][3][4][5][6][7] Several studies have reported that about 40% of the patients affected by TSCI are tetraplegics, and around 40% have a neurologically complete spinal lesion. 2,[5][6][7] The annual incidence of TSCI in Europe has been reported to be about 17.5 patients per million, whereas in North America it is reported to be around 40 per million population.…”

Section: Introductionmentioning

confidence: 99%

Traumatic spinal cord injuries: evidence from 30 years in a single centre

et al. 2014

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“…These effects can damage the patient's mental health and places an immense burden on society from a public health perspective. [2][3][4] The principal treatments for SCI include surgical stabilization and decompression. Physiotherapy and neurotrophic rehabilitation attenuate further damage, relieve spinal…”

Section: Introductionmentioning

confidence: 99%

Nerve growth factor delivery by ultrasound-mediated nanobubble destruction as a treatment for acute spinal cord injury in rats

Song¹,

Wang

Shen³

et al. 2017

IJN

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Background Spinal cord injuries (SCIs) can cause severe disability or death. Treatment options include surgical intervention, drug therapy, and stem cell transplantation. However, the efficacy of these methods for functional recovery remains unsatisfactory. Purpose This study was conducted to explore the effect of ultrasound (US)-mediated destruction of poly(lactic-co-glycolic acid) (PLGA) nanobubbles (NBs) expressing nerve growth factor (NGF) ( NGF /PLGA NBs) on nerve regeneration in rats following SCI. Materials and methods Adult male Sprague Dawley rats were randomly divided into four treatment groups after Allen hit models of SCI were established. The groups were normal saline (NS) group, NGF and NBs group, NGF and US group, and NGF /PLGA NBs and US group. Histological changes after SCI were observed by hematoxylin and eosin staining. Neuron viability was determined by Nissl staining. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling staining was used to examine cell apoptosis. NGF gene and protein expressions were detected by quantitative reverse transcription polymerase chain reaction and Western blotting. Green fluorescent protein expression in the spinal cord was examined using an inverted fluorescence microscope. The recovery of neural function was determined using the Basso, Beattie, and Bresnahan test. Results NGF therapy using US-mediated NGF /PLGA NBs destruction significantly increased NGF expression, attenuated histological injury, decreased neuron loss, inhibited neuronal apoptosis in injured spinal cords, and increased BBB scores in rats with SCI. Conclusion US-mediated NGF /PLGA NBs destruction effectively transfects the NGF gene into target tissues and has a significant effect on the injured spinal cord. The combination of US irradiation and gene therapy through NGF /PLGA NBs holds great promise for the future of nanomedicine and the development of noninvasive treatment options for SCI and other diseases.

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Epidemiology and Clinical Outcomes of Acute Spine Trauma and Spinal Cord Injury: Experience From a Specialized Spine Trauma Center in Canada in Comparison With a Large National Registry

Cited by 85 publications

References 31 publications

Avaliação epidemiológica dos pacientes vítimas de traumatismo raquimedular

Avaliação epidemiológica dos pacientes vítimas de traumatismo raquimedular

Traumatic spinal cord injuries: evidence from 30 years in a single centre

Nerve growth factor delivery by ultrasound-mediated nanobubble destruction as a treatment for acute spinal cord injury in rats

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