Epidemiological, clinical, and therapeutic features of typhoid intestinal perforation in a rural environment of Burkina Faso

Ouédraogo, Salfo; Ouangré, Edgar; Zida, Maurice

doi:10.1684/mst.2017.0661

Cited by 5 publications

(14 citation statements)

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“…Except that in Burkina Faso [21], a slight predominance of women was found with a sex ratio of 0.99.…”

Section: Sexmentioning

confidence: 76%

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Survival Study over 5 Years of Digestive Cancers in Tlemcen Province during 2011-2017

Abdrebbi¹,

Meguenni²

2020

JHS

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In the world, digestive cancers represent a major public health problem by their frequency and severity. Digestive tract cancers are very common malignant tumors worldwide and are an important cause of cancer-related death. The objective of our study was to determinate the survival of digestive cancers in the province of Tlemcen over a period of 5 years. This is a prognostic historical-prospective study with an exhaustive collection data, which consists of studying the 5-year survival of digestive cancers in the province of Tlemcen, of all patients with digestive cancers whatever the stage, diagnosed between 2011 and 2012 and histologically confirmed in subjects residing in the province of Tlemcen at the moment of diagnosis. The subjects of our study were identified from the cancer registry of Tlemcen. In total, 408 cases of digestive cancers were diagnosed over 2 years in Tlemcen province. Most digestive cancers were characterized by a predominance of men except for cancer of the liver, gallbladder and bile ducts but whatever the sex, these cancers occur mainly in subjects whose age is greater than or equal to 45 years. Topographically, for both sexes combined, the colorectum followed by the stomach were the organs most affected by digestive cancers. Histopathologically, a predominance of adenocarcinoma has been noted. The 5-year global survival rate of all digestive cancers was 55.4%, depending on the localization; colorectal cancer, small bowel cancer, gallbladder and bile ducts cancer, stomach and esophagus cancers are cancers of intermediate prognosis whose survival in 5 years is between 40% and 80%. Liver cancer and pancreatic cancer remain poor prognosis cancers with 5-year survival rates of 23.08% and 33.3% respectively. The survival of digestive cancers must be improved by adequate care and surveillance of patients. The prevention of colorectal cancers which occupy the first place among the digestive cancers is based essentially on the knowledge of the risk factors and the screening allowing the improvement of the survival rate. The registry of cancer remains a fundamental tool of any cancer control program; it constitutes a starting source for the analysis of survival.

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“…Except that in Burkina Faso [21], a slight predominance of women was found with a sex ratio of 0.99.…”

Section: Sexmentioning

confidence: 76%

“…In Burkina Faso, colorectal and gastric cancers were the most frequent and accounted together for 53.2% of digestive cancers [21].…”

Section: Localization Of Digestive Cancer By Frequencymentioning

confidence: 99%

Survival Study over 5 Years of Digestive Cancers in Tlemcen Province during 2011-2017

Abdrebbi¹,

Meguenni²

2020

JHS

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“…In urban Africa, ileal perforations are often the leading cause of peritonitis, with a mortality rate of up to 20% [9]. The mortality reported in developing countries is linked to a variety of factors, including sep-sis (diffuse peritonitis), late treatment, malnutrition in many patients, age (many patients are young children) inadequate antibiotic therapy and the scarcity or the total absence of therapeutic resources [4].…”

Section: Introductionmentioning

confidence: 99%

“…In Togo in 2016 Kassegne I et al Reported a frequency of 67.9% of acute generalized peritonitis by Typhic perforation [12]. In Burkina Faso in 2016 Ouedraogo S et al reported that 42.5% of the etiologies of peritonitis were related to typhoid fever [9]. In Mali in 2013, Togola B et al Reported that 29.0% of peritonitis was of typhoid origin [13].…”

Section: Introductionmentioning

confidence: 99%

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Acute Peritonitis Generalized by Typhoid Perforation at Kankan Regional Hospital

Cs¹,

Ka²,

Da³

et al. 2021

JJGH

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Typhoid intestinal perforation prognostic score in poor-resource settings

Adamou,

Magagi,

Habou

et al. 2023

J West Afr Coll Surg

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Background: Mortality from peritonitis due to typhoid intestinal perforation (TIP) in sub-Saharan Africa is high. Objectives: This study aimed to determine the predictive factors of mortality, propose a prognostic score, and determine the appropriate surgical treatment for TIP in low-resource settings. Materials and Methods: This was a retrospective data collection of peritonitis due to TIP admitted at Zinder National Hospital from 2014 to 2021. To build a typhoid intestinal perforation prognostic score (TIPPS), patients were randomised into two groups: a score-building group and a validation group. Univariate and multivariate analyses were performed to identify risk factors of mortality. The value of P <0.05 was assigned significant for all analyses. Results: TIP accounted for 52.4% ( n = 1132) of all cases of peritonitis ( n = 2159). The median age was 12 years. Rural provenance represented 72.2% ( n = 817). Deaths accounted for 10.5% ( n = 119). The factors influencing mortality were respiratory rate ≥24/min (odds ratio [OR] = 2.6, P = 0.000), systolic blood pressure <90 mmHg (OR = 0.31, P = 0.002), serum creatinine >20 mg/L (OR = 2.6, P ≤ 0.009), haemoglobin (OR = 2.1, P = 0.000), comorbidity (OR = 3.5, P = 0.001), the American Society of Anesthesiologists score IV&V (OR = 3.3, P = 0.000), admission and management delay > 72 h (OR = 3.2, P = 0.001), and a number of perforations (OR = 2.4, P = 0.0001). These factors were used to build a “TIPPS” score, which ranged from 8 to 20. The risk of mortality was associated with increased TIPPS. The performance of this score was good in the two groups (area under receiver operating characteristic > 0.83). According to the severity and mortality risk of TIP, we classified TIPS into four grades: grade I (low risk: 8–10), grade II (moderate risk: 11–13), grade III (high risk: 14–16) and grade IV (very high risk: 17–20). Conclusion: The TIPPS is simple. It can describe the severity of the disease and can predict the risk of death. The study highlights the importance and impact of timely and adequate perioperative resuscitation in more complicated cases.

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Epidemiological, clinical, and therapeutic features of typhoid intestinal perforation in a rural environment of Burkina Faso

Cited by 5 publications

References 0 publications

Survival Study over 5 Years of Digestive Cancers in Tlemcen Province during 2011-2017

Survival Study over 5 Years of Digestive Cancers in Tlemcen Province during 2011-2017

Acute Peritonitis Generalized by Typhoid Perforation at Kankan Regional Hospital

Typhoid intestinal perforation prognostic score in poor-resource settings

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