Epidemiological Aspects of Human Papillomavirus Infection and Cervical Cancer in Brazil

Cavalcanti, Sílvia M. B.; Zardo, Lucília G.; Passos, Mauro Romero Leal; Oliveira, Ledy H. S.

doi:10.1053/jinf.1999.0596

Cited by 42 publications

(35 citation statements)

References 28 publications

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“…Nevertheless, we were able to evaluate persistent lesions that were left untreated by patients that did not return for clinical follow-up. We also observed that 95.4% of these patients were positive for high-risk HPV infection, similar to previous studies in which it was suggested that persistent processes caused by oncogenic viruses are required for the development and maintenance of SIL [21,22]. Absence of follow up by the patients, fear of treatment, and misinformation, are problems to be solved by public campaigns that explain the true risks, the probability of dissemination and the importance of treatment.…”

Section: Retrospective Analysis Of the Patients Samples (N)supporting

confidence: 89%

Human papillomavirus infection in Rio de Janeiro, Brazil: a retrospective study

Carvalho¹,

Carestiato²,

Perdigão³

et al. 2005

Braz J Infect Dis

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There is considerable data to support a central role for human papillomavirus (HPV) in the etiology of cervical cancer. More than a 100 HPV types have been described, and 40 have been isolated from benign and malignant genital lesions. Consequently, there is strong motivation to evaluate HPV testing for cervical cancer screening. Few studies concerning the natural history of HPV infection have been conducted in the state of Rio de Janeiro. We determined the prevalence of HPV types in female genital lesions by using Hybrid Capture Assay (HCA) and we retrospectively analyzed the course of HPV infection. Our sample included 788 women attended at Laboratórios Sérgio Franco. The average age of the participants was 29.6 years. HPV prevalence and cytological diagnosis were determined. The overall prevalence of HPV DNA in the study group was 50.1% (395/788), ranging from 25% (NORMAL) to 100% in high-grade intraepithelial lesions (HSIL). High risk HPV was found in 12% inflammatory, 58.3% HPV, 63.2% LSIL and 100% HSIL. A retrospective analysis of 78 patients showed that 22 presented persistent lesions, 2 had progressive lesions, 4 had regressive lesions, 13 showed latent infections, 18 were transiently infected and 19 were submitted to curative treatment. No cases of cancer were registered in this population, which can afford private medical care and regular follow-up exams. We suggest that HCA be used in specific cases involving persistent and recurrent lesions.

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Section: Retrospective Analysis Of the Patients Samples (N)supporting

confidence: 89%

Human papillomavirus infection in Rio de Janeiro, Brazil: a retrospective study

Carvalho¹,

Carestiato²,

Perdigão³

et al. 2005

Braz J Infect Dis

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“…Thus, viral testing to reduce false cytological diagnosis is appealing, given the high frequency of cervical cancer in Brazil [8]. Testing for HPV has been shown to detect SILs missed by false-negative Pap smears.…”

Section: Discussionmentioning

confidence: 99%

Detection of human papillomavirus DNA by the hybrid capture assay

Carvalho¹,

Almeida²,

Leite³

et al. 2003

Braz J Infect Dis

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Human Papillomavirus (HPV) infection is the main cause of cervical cancers and cervical intraepithelial neoplasias (CIN) worldwide. Consequently, it would be useful to evaluate HPV testing to screen for cervical cancer. Recently developed, the second-generation Hybrid Capture (HCA II) test is a non-radioactive, relatively rapid, liquid hybridization assay designed to detect 18 HPV types, divided into high and low-risk groups. We evaluated 1055 women for HPV infection with the HCA II test. Five hundred and ten (48.3%) of these women had HPV infection; 60 (11.8%) had low cancer-risk HPV DNA; 269 (52.7%) had high-risk HPV types and 181 (35.5%) had both groups. Hence, 450 women (88.2%) in this HPV-infected group had at least one high risk HPV type, and were therefore considered to be at high risk for cancer. Among the group with Papanicolaou (Pap) test results, the overall prevalence of HPV DNA was 58.4%.

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“…De acordo com Bosch et al (2002), em estudo de caso controle com amostras provenientes da cérvice uterina é observado a presença de HPV na faixa e 90% a 100%, com o auxílio de técnicas moleculares. No Brasil, estudos similares observaram a presença do HPV entre 73,9% a 95% das amostras (Noronha et al 1999;Cavalcanti et al 2000;Oliveira et al 2003). As variações encontradas nos trabalhos citados e a porcentagem de HPV observada no presente estudo, deve-se a dois fatores: os trabalhos citados correlacionam os resultados do uso de diferentes técnicas moleculares na metodologia como, por exemplo, PCR, RFLP, hibridização in situ e ou captura híbrida I e II.…”

Section: Resultsunclassified

Ocorrência de papilomavírus humano na cérvice uterina de mulheres da região ocidental da Amazônia Brasileira

et al. 2013

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A ocorrência do papiloma vírus humano (HPV) é um problema de saúde pública, pois tem sido associado ao câncer. O objetivo da pesquisa foi identificar a ocorrência de papilomavírus humano na cérvice uterina de mulheres da região ocidental da Amazônia Brasileira. O estudo foi realizado na capital de Rondônia, Porto Velho. Occurrence of human papillomavirus in uterine cervix of women in the western Brazilian Amazon ABSTRACTThe occurrence of human papillomavirus (HPV) is a public health problem, because it has been linked to cancer. The aim of this research was to identify the occurrence of human papillomavirus in uterine cervix of women in the western Brazilian Amazon. The study was conducted in the capital of Rondonia, Porto Velho. We identified the types of HPV, also we correlated molecular results with those of colpocytologic tests coming from 334 women who underwent preventive examinations at the Brazilian Unified Health System. From samples, we obtained genetic material of the human papillomavirus (HPV ADN) and amplified the 450-bp fragment from the conserved region of the L1 gene, which was submitted to restriction fragment length polymorphism (RFLP) analysis. Of the 334 samples analyzed, 31% were confirmed to have the presence of viral material (HPV ADN). We detected the existence of the following HPV types: 16, 18, 33, 53 and 58, which identifies the group of high oncogenic risk, with 72% (74/103) of occurrence. Also we found HPV types 11, 42 and 44, which belong to the group of low oncogenic risk, with 28% of occurrence. The recurrent profiles in the development of the analysis were HPV-16 and -18, with 17% and 16% respectively. We found that more than 80% of the samples that contained viral material did not show any abnormal cell in the cytology test. This finding reinforces the need to disseminate the use of molecular techniques in conventional diagnostics.

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Epidemiological Aspects of Human Papillomavirus Infection and Cervical Cancer in Brazil

Cited by 42 publications

References 28 publications

Human papillomavirus infection in Rio de Janeiro, Brazil: a retrospective study

Human papillomavirus infection in Rio de Janeiro, Brazil: a retrospective study

Detection of human papillomavirus DNA by the hybrid capture assay

Ocorrência de papilomavírus humano na cérvice uterina de mulheres da região ocidental da Amazônia Brasileira

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