Epidemiological and genetic study of 121 cases of oral clefts in Kuwait

Al-Bustan, Suzanne A.; El-Zawahri, Mokhtar; Al-Adsani, Amani M.; Bang, Ramesshwar L.; Ghunaim, Ibrahim; Maher, Brion S.; Weinberg, Seth M.; Marazita, Mary L.

doi:10.1034/j.1600-0544.2002.02203.x

Cited by 30 publications

(24 citation statements)

References 24 publications

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“…CP occurred infrequently (8.5%) compared to other OFC. The results are consistent with most of previous studies [Gregg et al, 1980; Al‐Bustan et al, 2002; Baek et al, 2002; Suleiman et al, 2005]. The usual ratio of non‐associated CLP and CP is about 2–2.5:1 [Czeizel and Tusnadi, 1971; Tolarova and Cervenka, 1998; Hashmi et al, 2005].…”

Section: Discussionsupporting

confidence: 92%

High prevalence of orofacial clefts in Shanxi Province in northern China, 2003–2004

Ren

Liu

et al. 2008

American J of Med Genetics Pt A

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Shanxi Province in northern China has been identified as an area with the highest prevalence of neural tube defects in the world; however, few reports exist on the prevalence of orofacial clefts (OFC). We examined the prevalence of OFC and their association with selected characteristics. Data came from a population-based birth defects surveillance system in four counties of Shanxi Province. The system captures information on all live births, stillbirths of at least 20 weeks gestation, and pregnancy terminations at any gestational age after prenatal diagnosis of a birth defect. Out of 25,355 births in 2003-2004, 83 cases with orofacial clefts were identified resulting in a birth prevalence of 3.27 per 1,000. Other major external birth defects were present in 12 (14.5%) OFC cases. Cleft lip with palate (CLP), cleft lip alone (CL) and cleft palate alone (CP) accounted for 62.0%, 29.6% and 8.4% of OFC cases without additional external defects, respectively. The male to female ratio was 1.04 (95%CI: 0.67-1.60) for all OFC, 1.46 (95%CI: 0.80-2.68) for CLP, 1.23 (95%CI: 0.52-2.91) for CL, 0.46 (95%CI: 0.08-2.51) for CP without additional major external defects, and 0.31(95%CI: 0.08-1.13) for OFC with additional external defects. The prevalence of OFC without additional external defects was increased with decreased maternal age (P < 0.05) and increased maternal education (P < 0.05). The birth prevalence of OFC in Shanxi Province of northern China is among the highest worldwide. Further studies are required to define the factors associated with excess risk of clefts.

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Section: Discussionsupporting

confidence: 92%

High prevalence of orofacial clefts in Shanxi Province in northern China, 2003–2004

Ren

Liu

et al. 2008

American J of Med Genetics Pt A

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“…Consanguineous marriages are an important factor in the development of cleft anomalies, as well as a host of other genetic abnormalities, and should be discouraged 20. Al-Bustan et al21 evaluated epidemiological factors such as gender and consanguinity that may be associated with cleft lip or cleft palate in Kuwait and found no definite association between consanguinity and the occurrence of facial clefts, but our study showed a statistically significant association between consanguinity and occurrence of craniofacial anomalies.…”

Section: Discussioncontrasting

confidence: 61%

Pattern of craniofacial anomalies seen in a tertiary care hospital in Saudi Arabia

Aljohar

Ravichandran

Subhani

2011

Annals of Saudi Medicine

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BACKGROUND AND OBJECTIVE:To date, there are no published studies from Saudi Arabia on the incidence or etiology of craniofacial anomalies. This study aimed to report the patterns of craniofacial anomalies in Saudi Arabia.DESIGN AND SETTING:Hospital-based, descriptive study conducted during 2002 to 2009 in the Cleft Lip/Palate and Craniofacial Anomalies Registry at King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.PATIENTS AND METHODS:Data was collected on craniofacial patients in the registry.RESULTS:Of the 447 craniofacial patients (male, 242; female, 205), 109 (24.4%) had only cranial anomalies, 261 (58.4%) had only facial anomalies and 77 (17.2%) had both of these conditions. Craniosynostosis was seen in 33.3% of the total patients (81 males and 68 females). Of the 65 craniosynostosis syndromic patients, 25 (38.5%) had Apert syndrome and 18 (27.7%) had Crouzon syndrome. Among facial anomalies, 47 (19.4%) had dysmorphic features, followed by 35 (14.5%) with micrognathia. Among facial syndromes, 72 (59.0%) were observed to have Pierre-Robin sequence, 17 (13.9%) had Goldenhar syndrome and another 17 (13.9%) had Van der Woude syndrome. Cleft palate was more common in 171 (56.8%) patients as an associated deformity, followed by cleft lip with cleft palate in 99 (32.9%) and cleft lip in 23 (7.6%) patients. Of the 224 patients having other congenital anomalies, the cardiovascular system was most commonly affected, with 46 (20.5%) children diagnosed with congenital heart disease. A family history of anomalies was observed more in children born to parents of a consanguineous marriage than in those whose parents were unrelated (P=.01).CONCLUSIONS:Additional efforts should be made towards creating awareness among the general population about these deformities in relation to consanguinity.

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“…Al-Awadi et al (1986) reported that prenatal and neonatal losses among consanguineous couples are higher than among non-consanguineous couples. For the occurrence of oral clefts, however, Al-Bustan et al (2002) showed that there is no definite association with consanguineous marriage.…”

Section: Introductionmentioning

confidence: 93%

The Health Consequences of Consanguineous Marriage in Kuwait

Al-Kandari¹

2007

Anthropology of the Middle East

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The rate of consanguineous marriage in Kuwait is considered to be high. Several research studies have shown that marriage among relatives is one of the major factors leading to health problems because it increases homozygosis. This article deals with both cultural and physical aspects by examining the health consequences of consanguineous marriages in Kuwait. Variables such as reproductive wastage, health problems in the offspring and infant mortality are included and measured in relation to other socio-cultural variables. Cultural variables such as the respondents' roots (Bedouin and non-Bedouin) and beliefs (Muslim Sunni and Muslim Shi'a) are also examined. The results show that there is no significant association between consanguineous and non-consanguineous marriages in the rate of abortion or the mortality of infants and children up to five years old. Finally, the data reveal significant differences between the genetic and genetic-environmental diseases in consanguineous couples' offspring and those of non-consanguineous couples. Since some of these findings contradict those of other studies, more research is needed.

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Epidemiological and genetic study of 121 cases of oral clefts in Kuwait

Abstract: No definite association was observed between consanguinity and the occurrence of facial clefts in Kuwait. General transmission models in the full data set showed no evidence of heterogeneity in the results between the Arab and nomad subsets.

Cited by 30 publications

References 24 publications

High prevalence of orofacial clefts in Shanxi Province in northern China, 2003–2004

High prevalence of orofacial clefts in Shanxi Province in northern China, 2003–2004

Pattern of craniofacial anomalies seen in a tertiary care hospital in Saudi Arabia

The Health Consequences of Consanguineous Marriage in Kuwait

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