Epidemiologic Approach to the Relationship between Diabetes and Cancer: A Systematic Review Study

Abstract

Introduction: Diabetes patients have been reported to increase the risk of cancer by a large proportion than non-diabetic patients. In this study, we intend to examine the relationship between these two diseases by examining several studies. Therefore, this systematic review was conducted to determine the epidemiological approach to the relationship between diabetes and cancer. Materials and Methods:This study was a systematic review based on the Broome method. In this study, using the papers published in the last 17 years in relation to the epidemiological approach to the relationship between diabetes and cancer. Searching articles in search engines, scientific sites and databases, Google Scholar, Embase, Sciencedirect, PubMed, in Persian and English. In the first phase, 49 articles were found. Of these, 14 articles related to the topic that were published in the last 17 years were reviewed.Results: In this study, 14 articles were reviewed that revealed a link between diabetes and cancer and a serious risk for cancer. One of these studies showed that there was a significant relationship between type 2 diabetes and colon adenomas. Exposure to insulin and thiazolidinedione was associated with the formation of adenoma, and none of the anti-inflammatory drugs and HbA1c levels were predictive of adenoma. Conclusion:In this study, there was a significant relationship between diabetes and various types of cancer. Therefore, it is necessary to emphasize the screening of breast cancer and other types of cancer by conducting tests and diagnostic work for the rapid diagnosis of cancer among diabetic patients. Also, diabetes has increased the risk of developing another dangerous disease, such as cancer.