Epidemiologia Da Leishmaniose Visceral No Municipio De Três Lagoas ‐ Mato Grosso Do Sul, Uma Nova Região Endêmica No Brasil

Lopez, Luis Fernando Baldino; Carneiro, Luiz Euribel Pretes; Lope, Ana Lúcia Kawaminami; Brighenti, Karina Brighenti; Flores, Edilson Ferreira; Zuque, Maria Angelina da Silva; Peresi-Lordelo, Eliana

doi:10.1016/j.bjid.2020.101213

Cited by 2 publications

(8 citation statements)

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“…International border areas can also generate situations of vulnerability to the health of populations (Pêgo & Moura, 2018), especially in the presence of sandflies and dogs (specifically those that live on the street) (Oliveira et al, 2016;Lopez et al, 2021). Thus, understanding the epidemiological profile of VL in border regions provides better knowledge about the disease and supports managers and health professionals in the construction of measures, as well as in directing and prioritizing areas to be worked (Maia-Elkhoury et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, the most affected state with an international border and twin city were Mato Grosso do Sul and Corumbá, respectively. According to epidemiological evidence, the presence of the parasite in these regions can be attributed to the construction of a railway that originated in Bolivia, a highway that was built between Três Lagoas and Corumbá, and a natural gas pipeline that was built between Bolivia and Brazil (Lopez et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…The migratory process took human and canine populations from rural areas where the disease was endemic to cities' peripheral areas (Costa et al, 2018;Salomón et al, 2015;Oliveira et al, 2016). Consequently, the state of Mato Grosso do Sul began to be considered a new Brazilian endemic region for VL (Lopez et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…Even with actions of the Visceral Leishmaniasis Surveillance and Control Program (Brasil, 2016a) that targets entomological and animal reservoirs and the treatment of diagnosed human cases, Brazil still has approximately 96% of VL cases in Latin America (Maia-Elkhoury et al, 2021). Thus, one can question whether these actions are indeed sufficiently effective to reduce the incidence of VL in Brazil (Costa et al, 2018;Salomón et al, 2015;Oliveira et al, 2016;Lopez et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, sandflies and dogs (specifically dogs that live on the street) circulate freely with no restrictions, thereby favoring the spread of VL. Several studies have reported the presence of sandflies in the border region, especially the species Lutzomyia cruzi (Oliveira et al, 2016), and dogs that are diagnosed with leishmaniasis (Lopez et al, 2021). Therefore, international border areas (i.e., areas with at least two international territories) can generate situations of vulnerability to health of the population (Pêgo & Moura, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Epidemiological aspects of visceral leishmaniasis in Brazil and in international border regions

Oliveira

Moreira

2021

RSD

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Objectives: To verify the number of visceral leishmaniasis (VL) cases in Brazil and its states and twin cities, with a focus on the state and twin city with the highest number of cases. We investigated social, demographic, laboratory and clinical aspects of these cases. Methodological design: We performed a descriptive study using a quantitative approach and data from 2010 to 2019 that were obtained through a public domain website, the Informatics Department of the Unified Health System. The incidence rate of VL cases was calculated per 100,000 inhabitants. software. Results: In Brazil, 35,886 VL cases were reported, with 2,834 cases in international border states and 148 cases in twin cities. The state and twin city with the highest number of cases were Mato Grosso do Sul (1,834 cases) and Corumbá (94 cases), respectively, with annual mean incidence rates of 6.4 and 8.3 cases per 100,000 inhabitants. In Mato Grosso do Sul and Corumbá, the disease was more frequent in male and brown-skinned individuals who had up to 8 years of education (age range: 1 to > 80 years old). Most of the cases occurred in urban areas, was diagnosed by laboratory tests and evolved to cure (p < 0.05). Conclusions: A high number of VL cases in Brazil was found during the period of study. The cases were distributed in 10 states with international borders and eight twin cities. These findings draw attention to the greater need for management programs to control and prevent VL.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Epidemiological aspects of visceral leishmaniasis in Brazil and in international border regions

Oliveira

Moreira

2021

RSD

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ELISA with recombinant antigen Lb6H validated for the diagnosis of American tegumentary leishmaniasis

Valencia-Portillo,

Lindoso,

Celeste

et al. 2024

PLoS ONE

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American tegumentary leishmaniasis (ATL) diagnosis is an open question, and the search for a solution is urgent. The available tests that detect the etiological agent of the infection are specific for ATL diagnosis. However, they present disadvantages, such as low sensitivity and the need for invasive procedures to obtain the samples. Immunological methods (leishmanin skin test and search for anti-Leishmania antibodies) are good alternatives to the etiological diagnosis of ATL. Presently, we face problems with disease confirmation due to the discontinuity in the production of leishmanin skin test antigen, particularly in resource-poor settings. Aiming to diagnose ATL, we validated rLb6H-ELISA for IgG antibodies using 1,091 samples from leishmaniasis patients and healthy controls, divided into four panels, living in 19 Brazilian endemic and non-endemic states. The rLb6H-ELISA showed a sensitivity of 98.6% and a specificity of 100.0%, with the reference panel comprising 70 ATL patient samples and 70 healthy controls. The reproducibility evaluation showed a coefficient of variation of positive samples ≤ 8.20% for repeatability, ≤ 17,97% for reproducibility, and ≤ 8.12% for homogeneity. The plates sensitized with rLb6H were stable at 4°C and -20°C for 180 days and 37°C for seven days, indicating 12 months of validity. In samples of ATL patients from five research and healthcare centers in endemic and non-endemic areas, rLb6H-ELISA showed a sensitivity of 84.0%; no significant statistical difference was observed among the five centers (chi-square test, p = 0.13). In samples of healthy controls from four areas with different endemicity, a specificity of 92.4% was obtained; lower specificity was obtained in a visceral leishmaniasis high endemicity locality (chi-square test, p<0.001). Cross-reactivity was assessed in 166 other disease samples with a positivity of 13.9%. Based on the good diagnostic performance and the reproducibility and stability of the antigen, we suggest using ELISA-rLb6H to diagnose ATL.

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Epidemiologia Da Leishmaniose Visceral No Municipio De Três Lagoas ‐ Mato Grosso Do Sul, Uma Nova Região Endêmica No Brasil

Cited by 2 publications

References 0 publications

Epidemiological aspects of visceral leishmaniasis in Brazil and in international border regions

Epidemiological aspects of visceral leishmaniasis in Brazil and in international border regions

ELISA with recombinant antigen Lb6H validated for the diagnosis of American tegumentary leishmaniasis

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