Epidemic of Community-Acquired Methicillin-Resistant Staphylococcus aureus Infections

Purcell, Kevin; Fergie, Jaime

doi:10.1001/archpedi.159.10.980

Cited by 167 publications

(125 citation statements)

References 30 publications

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“…Of increasing concern, however, is the role of keyboards in the non-hospital environment as pathogen reservoirs. Because the asymptomatic carriage of MRSA in humans is increasing (Creech et al, 2005;Hidron et al, 2005) along with the occurrence of community-associated MRSA infections (Purcell and Fergie, 2005), it follows that the ubiquitous sharing of public computers by a broad user base might facilitate increased transmission and prevalence of MRSA throughout the community. Therefore, we targeted computer facilities in a metropolitan university to determine the prevalence of MRSA contamination of computers that feature a broad student and staff user base.…”

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confidence: 99%

Public computer surfaces are reservoirs for methicillin-resistant staphylococci

2007

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The role of computer keyboards used by students of a metropolitan university as reservoirs of antibiotic-resistant staphylococci was determined. Putative methicillin (oxacillin)-resistant staphylococci isolates were identified from keyboard swabs following a combination of biochemical and genetic analyses. Of 24 keyboards surveyed, 17 were contaminated with staphylococci that grew in the presence of oxacillin (2 mg l À1 ). Methicillin (oxacillin)-resistant Staphylococcus aureus (MRSA), -S. epidermidis (MRSE) and -S. hominis (MRSH) were present on two, five and two keyboards, respectively, while all three staphylococci co-contaminated one keyboard. Furthermore, these were found to be part of a greater community of oxacillin-resistant bacteria. Combined with the broad user base common to public computers, the presence of antibiotic-resistant staphylococci on keyboard surfaces might impact the transmission and prevalence of pathogens throughout the community.

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confidence: 99%

Public computer surfaces are reservoirs for methicillin-resistant staphylococci

2007

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“…5 Purcell e Fergie demonstraram que, em 1990, 2,9% dos S. aureus isolados eram meticilina-resistentes. 5 Em 2000, a prevalência aumentou para 19% e para 62,4% em 2003.…”

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“…5 Purcell e Fergie demonstraram que, em 1990, 2,9% dos S. aureus isolados eram meticilina-resistentes. 5 Em 2000, a prevalência aumentou para 19% e para 62,4% em 2003. 5 Outros estudos apontam para prevalência de 53% de S. aureus meticilina-resistente.…”

Section: Discussionunclassified

“…5 Em 2000, a prevalência aumentou para 19% e para 62,4% em 2003. 5 Outros estudos apontam para prevalência de 53% de S. aureus meticilina-resistente. 6 As manifestações clínicas podem variar desde lesões cutâneas sem gravidade até choque séptico.…”

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“…5,7,8 Os abscessos e as furunculoses são as lesões mais relatadas. 2,3,5,6,8 Também são descritos celulite, pápulas ou nódulos eritematosos, placas com crostas (impetigo) ou ainda FIGURA 1: Lesões furunculoides em coxa FIGURA 2: Linha 1. amostra da paciente deste caso; Linha 2. amostra pertencente a uma variante do clone OSPC, usada para comparação; Linha 3. amostra do clone BEC (Brazilian epidemic clone), típica do MRSA hospitalar a combinação desses quadros clínicos. 6 A resistência à meticilina ocorre pela produção da PBP2a, proteína ligadora à penicilina que diminui a atividade da maioria das penicilinas.…”

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CA-MRSA em furunculose: relato de caso do sul do Brasil

Razera

Stefani

Bonamigo

et al. 2009

An. Bras. Dermatol.

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Resumo: Staphylococcus aureus resistente à meticilina (MRSA), outrora isolado especificamente em ambientes hospitalares, vem sendo identificado como causador de infecções cutâneas em pacientes da comunidade. Neste artigo, é relatado um caso do sul do Brasil com furunculose por CA-MRSA. O microrganismo isolado foi submetido a exames de PCR para o gene mecA e para o gene que codifica a leucocidina de Panton-Valentine. Esses exames permitiram a identificação genotípica do CA-MRSA. Palavras-chave: Furunculose; Resistência a meticilina; Staphylococcus aureus Abstract: Methicillin-resistant Staphylococcus aureus (MRSA), particularly isolated at hospital setting, has been identified in cutaneous infections of community patients. This paper reports a case of furunculosis from the southern Brazil. Dermatologists must be attentive to this emergent etiological diagnosis. The isolated microorganism was subjected to PCR for gene mecA and to PCR for the gene that encodes the leukocidin of Panton-Valentine. These exams enabled genotypic identification of CA-MRSA.

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National Trends in Ambulatory Visits and Antibiotic Prescribing for Skin and Soft-Tissue Infections

et al. 2008

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Background: Community-acquired methicillinresistant Staphylococcus aureus (CA-MRSA) has emerged as a common cause of skin and soft-tissue infections (SSTIs) in the United States. It is unknown whether this development has affected the national rate of visits to primary care practices and emergency departments (EDs) and whether changes in antibiotic prescribing have occurred.Methods: We examined visits by patients with SSTIs to physician offices, hospital outpatient departments, and EDs using the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey from 1997 to 2005. We estimated annual visit rates for all SSTIs and a subset classified as abscess/cellulitis. For abscess/cellulitis visits, we examined trends in characteristics of patients and clinical settings and in antibiotic prescribing.Results: Overall rate of visits for SSTIs increased from 32.1 to 48.1 visits per 1000 population (50%; P=.003 for trend), reaching 14.2 million by 2005. More than 95% of this change was attributable to visits for abscess/ cellulitis, which increased from 17.3 to 32.5 visits per 1000 population (88% increase; P Ͻ .001 for trend). The largest relative increases occurred in EDs (especially in high safety-net-status EDs and in the South), among black patients, and among patients younger than 18 years. Use of antibiotics recommended for CA-MRSA increased from 7% to 28% of visits (P Ͻ .001) during the study period. Independent predictors of treatment with these antibiotics included being younger than 45 years, living in the South, and an ED setting. Conclusions:The incidence of SSTIs has rapidly increased nationwide in the CA-MRSA era and appears to disproportionately affect certain populations. Although physicians are beginning to modify antibiotic prescribing practices, opportunities for improvement exist, targeting physicians caring for patients who are at high risk.

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Epidemic of Community-Acquired Methicillin-Resistant Staphylococcus aureus Infections

Abstract: The rapid emergence of CAMRSA as a cause of noninvasive and invasive infections in children, which started occurring in the 1990s, has reached epidemic proportions.

Cited by 167 publications

References 30 publications

Public computer surfaces are reservoirs for methicillin-resistant staphylococci

Public computer surfaces are reservoirs for methicillin-resistant staphylococci

CA-MRSA em furunculose: relato de caso do sul do Brasil

National Trends in Ambulatory Visits and Antibiotic Prescribing for Skin and Soft-Tissue Infections

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