2011
DOI: 10.1093/cvr/cvr099
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Abstract: The better preservation of LV geometry afforded by ADSC sheets is associated with increased survival and engraftment, which supports the concept of an epicardial delivery of cell-seeded biomaterials.

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Cited by 105 publications
(106 citation statements)
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“…Despite the use of autologous skeletal myoblasts that lack the capacity to differentiate into cardiac myocytes and do not couple to the host myocardium (74), improvements of cardiac function were reported. This and former studies with mesenchymal stroma cells (53) or adipocytes (40) support the idea that the effects of the cell sheet technique are, at least to a large part, due to paracrine activity and mechanical stabilization of the scarred ventricle (33). Advantages of the cell sheet technique are its simplicity, the selection against dead cells in the preimplantation step in vitro, and very high cellular retention rate.…”
Section: Tissue Engineering For Cardiac Repair: Different Approachessupporting
confidence: 53%
“…Despite the use of autologous skeletal myoblasts that lack the capacity to differentiate into cardiac myocytes and do not couple to the host myocardium (74), improvements of cardiac function were reported. This and former studies with mesenchymal stroma cells (53) or adipocytes (40) support the idea that the effects of the cell sheet technique are, at least to a large part, due to paracrine activity and mechanical stabilization of the scarred ventricle (33). Advantages of the cell sheet technique are its simplicity, the selection against dead cells in the preimplantation step in vitro, and very high cellular retention rate.…”
Section: Tissue Engineering For Cardiac Repair: Different Approachessupporting
confidence: 53%
“…To trace cells in the transplanted cell sheets, in some experiments, monolayer cell sheets were stained with PKH26 red fluorescent cell linker kit (SigmaAldrich Co., St. Louis, MO) for 5 min before cell seeding. For quantitative analysis on mRNA of infarcted hearts, mRNA of cardiac tissue in the border zone of myocardium and scar at 4 weeks after transplanthere have been several adverse effects on injected cells such as loss of living cells (2) and arrhythmogenesis (7). Tissue engineering using a cell sheet has been developed to overcome these disadvantages (18).…”
Section: In Vivo Studymentioning
confidence: 99%
“…Furthermore, ASCs secrete multiple angiogenic growth factors that promote neovascularization (15), and ASCs transplanted into an ischemic site improve blood perfusion with increases in tissue capillary density (9). Thus, ASC sheets may be useful for restoration of cardiac function and remodeling of MI hearts to replace myoblast cell sheets (2), but it has never tested whether ASC sheets could improve cardiac function, remodeling, and dysregulation of cardiac β-adrenergic signaling of MI hearts in comparison with myoblast cell sheets. In the present report, we studied effects of ASC sheets on rat MI hearts and compared with those of myoblast cell sheets.…”
Section: In Vivo Studymentioning
confidence: 99%
“…Adiposederived stem cells (ADSCs) and adipocytes can be used to construct cell sheets that improve left ventricular function (19,26). Adipose tissue-derived cells therefore have potential as a cell source for the construction of cell sheets designed to ameliorate cardiac dysfunction.…”
Section: Bone Marrow Stem Cells and Adipose Tissue-derived Cellsmentioning
confidence: 99%