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“…The molecular bases of these changes are unknown. EphA4 activity has been associated with Rho family of GTPases and cytoskeleton dynamics (54,55) and is known to activate the Jak/STAT pathway (11). In addition, cross-talk with the fibroblast growth factor receptor (FGFR) family has also been reported (56,57).…”
Section: Cd25mentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…The molecular bases of these changes are unknown. EphA4 activity has been associated with Rho family of GTPases and cytoskeleton dynamics (54,55) and is known to activate the Jak/STAT pathway (11). In addition, cross-talk with the fibroblast growth factor receptor (FGFR) family has also been reported (56,57).…”
Section: Cd25mentioning
“…Previously, we identified a single amino acid substitution (Arg758Cys) in the active site of the kinase domain of Ephrin receptor B2 (EphB2) that is perfectly associated with head crests in pigeons (Shapiro et al 2013). EphB2 is weakly expressed in the mesenchyme of feather primordia and its precise role in feather development is not well understood (Suksaweang et al 2012;Shapiro et al 2013); however, other Eph family members are involved in tissue patterning, placode boundary stabilization, and morphogenesis affecting the feather cytoskeleton (Xu et al 2000;McKinnell et al 2004;Suksaweang et al 2012). The same substitution was homozygous in pigeons with a wide variety of crest phenotypes, from simple peaks to elaborate hoods, demonstrating that inheritance of two copies of this variant is necessary for crest development.…”
Section: Introductionmentioning
“…A previous work (McKinnell et al, 2004a) showed that there is no RhoA or RhoB expression in the dermis, while RhoB is expressed in the epidermis, and that the use of a specific ROCK inhibitor prevents the formation of the placode. The implication of RhoB in the maintenance of the morphogenetic program leading to feather bud development is thus well demonstrated.…”
Section: Discussionmentioning
“…It was previously shown (McKinnell et al, 2004a) via in situ hybridization that RhoA is not expressed in HH-30 embryonic chick skin, and RhoB only in the placode. Using a RT-PCR (Fig.…”
Section: Dermal Fibroblast Migration Abilities In Adherent Cell Culturementioning
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