ePC-SAFT revised

Influence of electrolytes on liquid-liquid equilibria of water/1-butanol and on the partitioning of 5-hydroxymethylfurfural in water/1-butanol

“…The long-range interactions originating from charged species are taken into account with the Debye-Hückel theory that contributes with a ion to a res . In the literature the details of the approach of PC-SAFT [33,42] and the further development to ePC-SAFT [34,36] are available.…”

“…The newest development of ePC-SAFT [36] has been used in this work for the calculation of the fugacities required in eqs. (1) and (2).…”

“…and was based on the fact that the ePC-SAFT ion parameters were fitted [36] to the properties of binary water/salt solutions by using the dielectric constant of pure water.…”

A novel approach for predicting the dissolution profiles of pharmaceutical tablets

“…-component parameters of NAP, TMP, ions, water and 549buffer components as well as the binary interaction parameters 550 between the API and water, between the buffer components, 551 between the ions, between the buffer components and water as 552 well as those between the ions and water were taken from the 553 literature[23,26,51,52]. The parameters used within this work 554 are summarized inTables 2 and 3.…”

“…In the last decades, 49 several empirical, semi-empirical and mechanistic mathematical 50 models have been proposed to describe the API dissolution profiles 51 from a variety of solid pharmaceutical dosage forms, e.g. matrix 52 systems [1][2][3], erodible tablets [4,5], microspheres [6], hydrogels 53 [7], powders [8] and immediate release tablets [9][10][11][12]. Siepmann 54 and Siepmann [13] gave a detailed review of the empirical, 55 semi-empirical and mechanistic mathematical models that have 56 been applied to describe the API dissolution profiles from solid 57 pharmaceutical dosage forms.…”