EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: Evidence for a PPAR-γ–dependent mechanism

Li, Hang; Ruan, Xiong Z.; Powis, Stephen H.; Fernando, R.; Mon, Wint; Wheeler, David C.; Moorhead, John F.; Varghese, Zac

doi:10.1111/j.1523-1755.2005.00151.x

Cited by 297 publications

(205 citation statements)

References 35 publications

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“…Although n-3 fatty acids are potentially PPAR␥ ligands (27,28), fish oil and n-3 fatty acid species (C18:3n3, C20:5n-3, and C22:6n3) failed to stimulate adiponectin mRNA expression in 3T3L1 adipocytes, suggesting that n-3 fatty acids stimulate adiponectin secretion by an indirect mechanism or that they require in vivo metabolic processing to do so.…”

Section: Discussionmentioning

confidence: 92%

Fish Oil Regulates Adiponectin Secretion by a Peroxisome Proliferator–Activated Receptor-γ–Dependent Mechanism in Mice

et al. 2006

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Adiponectin has insulin-sensitizing, antiatherogenic, and anti-inflammatory properties, but little is known about factors that regulate its secretion. To examine the effect of fish oil on adiponectin secretion, mice were fed either a control diet or isocaloric diets containing 27% safflower oil or 27, 13.5, and 8% menhaden fish oil. Within 15 days, fish oil feeding raised plasma adiponectin concentrations twoto threefold in a dose-dependent manner, and the concentrations remained approximately twofold higher for 7 days when the fish oil diet was replaced by the safflower oil diet. Within 24 h, fish oil markedly induced transcription of the adiponectin gene in epididymal adipose tissue but not in subcutaneous fat. The increase of plasma adiponectin by fish oil was completely blocked by administration of the peroxisome proliferator-activated receptor (PPAR)␥ inhibitor bisphenol-A-diglycidyl ether. In contrast, there was no effect of fish oil feeding on adiponectin secretion in PPAR␣-null mice. These data suggest that fish oil is a naturally occurring potent regulator of adiponectin secretion in vivo and that it does so through a PPAR␥-dependent and PPAR␣-independent manner in epididymal fat. Diabetes 55: 924 -928, 2006

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Section: Discussionmentioning

confidence: 92%

Fish Oil Regulates Adiponectin Secretion by a Peroxisome Proliferator–Activated Receptor-γ–Dependent Mechanism in Mice

et al. 2006

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“…These cytokines can increase lipolysis and suppress preadipocyte differentiation (50,81), and thereby preadipocytes may increase their potency for proinflammatory gene expression and macrophage recruitment (39). However, contrary effects involving NF-B-and PPAR␥-dependent mechanisms have also been observed (34). Thus, pro-and anti-inflammatory effects of LC-n-3 PUFA can occur at the same time (65) and may vary widely depending on the cell type (75) and study conditions (17), such as treatment duration and the use of different high-fat diets, which can be based on either rapeseed/sunflower oil (57), safflower oil/lard (69), or palm oil (11).…”

Section: Discussionmentioning

confidence: 94%

Metabolic and immunomodulatory effects of n-3 fatty acids are different in mesenteric and epididymal adipose tissue of diet-induced obese mice

Ludwig

Worsch

Heikenwälder

et al. 2013

American Journal of Physiology-Endocrinology and Metabolism

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“…Bu konuda yapılan in vitro bir çalışmada böbrek hücresinde, EPA ve DHA'nın, PPARγ bağımlı bir yolak üzerinden, nükleer faktör kappa b (NF-κB) aktivasyonunu ve MCP-1 ekspresyonunu anlamlı şekilde azalttığı gösterilmiştir (52). Kronik böbrek hastalarında (son evre hariç) koroner girişim sonrasında gelişebilecek akut böbrek hasarının önlenmesinde α-tokoferol ve γ-tokoferol suplemantasyonunun anlamlı etkisinin olduğu bir çalışmada bildirilmiştir (61)…”

Section: Türk Nefroloji Diyaliz Ve Transplantasyon Dergisi Turkish Neunclassified

Kronik Böbrek Hastalığında Renal İnflamasyon ve Bazı Güncel Diyet Bileşenleri İlişkisi

Öztürk¹,

Nergiz-Unal²

2018

Turk Neph Dial Transpl

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ÖZKronik böbrek hastalığı, glomerüler filtrasyonun azalmasıyla böbrekte sıvı-solüt dengesinin düzenlen-mesi ve metabolik-endokrin fonksiyonlarda kronik ve ilerleyici bozulma hali olarak tanımlanabilir. Kronik böbrek hastalığı gelişiminde rol alan inflamasyon, kronik böbrek hastalığının sonucu olarak da ortaya çıkabilmekte ve KBH varlığına bağlı mortalite artışının en önemli nedenlerinden biri olarak kabul edilmektedir. İnflamasyon ve diyet etkileşimi ile ilgili yapılan güncel araştırmalar çoklu doymamış yağ asitleri, D vitamini, E vitamini gibi besin ögeleri ile karnitin, lipoik asit, flavanoidler, probiyotikler ve prebiyotikler gibi diğer diyet bileşenlerinin renal inflamasyon sürecindeki olumlu etkilerine işaret etmektedir. Derlemede, olası anti-inflamatuvar bazı diyet bileşenlerinin kronik böbrek hastalığı ile ilişkili inflamasyon üzerine etkileri incelenmiştir. ANAHTAR SÖZCÜKLER: Kronik böbrek hastalığı, Beslenme, İnflamasyon, Diyet ABSTRACTChronic kidney disease can be defined as chronic and progressive deterioration of the regulation of fluid-solute balance and metabolic-endocrine functions of the kidney due to diminishing glomerular filtration. Inflammation in renal disease can develop as a cause or an outcome, and it has been reported in recent studies that inflammation is among the most important causes of disease-related mortality. Investigations on inflammation and diet interactions have shown that the effects of nutrients such as polyunsaturated fatty acids, vitamin D, vitamin E and other dietary components such as carnitine, lipoic acid, flavanoids, probiotics and prebiotics may have positive effects on the renal inflammation process. In this review, the potential anti-inflammatory effects of some current dietary components in chronic kidney disease were studied.

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EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: Evidence for a PPAR-γ–dependent mechanism

Cited by 297 publications

References 35 publications

Fish Oil Regulates Adiponectin Secretion by a Peroxisome Proliferator–Activated Receptor-γ–Dependent Mechanism in Mice

Fish Oil Regulates Adiponectin Secretion by a Peroxisome Proliferator–Activated Receptor-γ–Dependent Mechanism in Mice

Metabolic and immunomodulatory effects of n-3 fatty acids are different in mesenteric and epididymal adipose tissue of diet-induced obese mice

Kronik Böbrek Hastalığında Renal İnflamasyon ve Bazı Güncel Diyet Bileşenleri İlişkisi

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