EP-1533: ICE-Studio - An Interactive visual research tool for image analysis

Nyholm, Tufve; Berglund, Martin; Brynolfsson, Patrik; Jönsson, Johan

doi:10.1016/s0167-8140(15)41525-7

Cited by 24 publications

(20 citation statements)

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“…Dose‐volume histograms illustrating both evaluated plans were exported from the treatment planning system for evaluation. Gamma pass rates (percentage of points satisfying a certain difference in dose within a given distance) calculated by the Medical Interactive Creative Environment (MICE)‐toolkit software developed at Umeå University were also used to compare each pair of results.…”

Section: Methodsmentioning

confidence: 99%

Zero TE‐based pseudo‐CT image conversion in the head and its application in PET/MR attenuation correction and MR‐guided radiation therapy planning

Wiesinger

Bylund

Yang

et al. 2018

Magnetic Resonance in Med

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Section: Methodsmentioning

confidence: 99%

Zero TE‐based pseudo‐CT image conversion in the head and its application in PET/MR attenuation correction and MR‐guided radiation therapy planning

Wiesinger

Bylund

Yang

et al. 2018

Magnetic Resonance in Med

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“…The final dosimetric analysis was carried out using the Medical Interactive Creative Environment (MICE), version 0.4.0.94 (available at www. gentleradiotherapy.se) (Nyholm et al 2015).…”

Section: Simulation Methodsmentioning

confidence: 99%

Motion induced interplay effects for VMAT radiotherapy

et al. 2018

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The purpose of this study was to develop a method to simulate breathing motion induced interplay effects for volumetric modulated arc therapy (VMAT), to verify the proposed method with measurements, and to use the method to investigate how interplay effects vary with different patient- and machine specific parameters. VMAT treatment plans were created on a virtual phantom in a treatment planning system (TPS). Interplay effects were simulated by dividing each plan into smaller sub-arcs using an in-house developed software and shifting the isocenter for each sub-arc to simulate a sin breathing motion in the superior-inferior direction. The simulations were performed for both flattening-filter (FF) and flattening-filter free (FFF) plans and for different breathing amplitudes, period times, initial breathing phases, dose levels, plan complexities, CTV sizes, and collimator angles. The resulting sub-arcs were calculated in the TPS, generating a dose distribution including the effects of motion. The interplay effects were separated from dose blurring and the relative dose differences to 2% and 98% of the CTV volume (ΔD and ΔD) were calculated. To verify the simulation method, measurements were carried out, both static and during motion, using a quasi-3D phantom and a motion platform. The results of the verification measurements during motion were comparable to the results of the static measurements. Considerable interplay effects were observed for individual fractions, with the minimum ΔD and maximum ΔD being -16.7% and 16.2%, respectively. The extent of interplay effects was larger for FFF compared to FF and generally increased for higher breathing amplitudes, larger period times, lower dose levels, and more complex treatment plans. Also, the interplay effects varied considerably with the initial breathing phase, and larger variations were observed for smaller CTV sizes. In conclusion, a method to simulate motion induced interplay effects was developed and verified with measurements, which allowed for a large number of treatment scenarios to be investigated. The simulations showed large interplay effects for individual fractions and that the extent of interplay effects varied with the breathing pattern, FFF/FF, dose level, CTV size, collimator angle, and the complexity of the treatment plan.

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“…A fast spoiled gradient echo (FSPGR) sequence with echo time/repetition time 3/7.24 ms, flip angle 12°, FOV 34 cm, in‐plane resolution 1.328 × 1.328 mm, slice thickness 7 mm, and bandwidth of 244 Hz/pixel was used to measure the signal and noise with and without the tabletop and coil holders. SNR was calculated using MICE Toolkit according to McCann et al . for six ROIs, shown in Fig.…”

Section: Methodsmentioning

confidence: 99%