Eosinophilic pustular folliculitis (Ofuji's disease). Immunohistochemical analysis

Eosinophilic pustular folliculitis (Ofuji's disease) in Singapore: A review of 23 adult cases

“…Furthermore, topical 0.5% piroxicam gel 9 and aspirin 11 have been reported to be effective, suggesting that the therapeutic efficacy may be a class effect for non-steroidal anti-inflammatory drugs in general, rather than restricted to indomethacin alone. This observation further supports the hypothesis that EPF is a result of underlying immune dysregulation 14,15,19,20 rather than secondary to an infective process.…”

Clinicopathologic challenge: Erythematous and edematous eruption of the face

“…11 This hypothesis seems to be confirmed by the evidence that ELAM-1 and VCAM-1 are also important adhesion molecules for eosinophils. 11 Differential diagnosis of EPF includes a wide variety of inflammatory lesions containing an eosinophilic infiltrate, such as arthropod bite-or drug-related reactions, eosinophilic cellulitis, fungal skin infections, and suppurative folliculitis. Arthropod bite reactions may often have a prominent eosinophilic component as part of the mixed inflammatory cellular dermal infiltrate.…”

“…Histologic examination of a new skin biopsy showed typical morphological features of EPF 10 . It has been suggested that the expression of intercellular adhesion molecule 1 (ICAM‐1) and endothelial and vascular cell adhesion molecules (ELAM‐1 and VCAM‐1, respectively) within and around hair follicles may explain the perifollicular eosinophilic infiltrate 11 . This hypothesis seems to be confirmed by the evidence that ELAM‐1 and VCAM‐1 are also important adhesion molecules for eosinophils 11 .…”

“…It has been suggested that the expression of intercellular adhesion molecule 1 (ICAM‐1) and endothelial and vascular cell adhesion molecules (ELAM‐1 and VCAM‐1, respectively) within and around hair follicles may explain the perifollicular eosinophilic infiltrate 11 . This hypothesis seems to be confirmed by the evidence that ELAM‐1 and VCAM‐1 are also important adhesion molecules for eosinophils 11 . Differential diagnosis of EPF includes a wide variety of inflammatory lesions containing an eosinophilic infiltrate, such as arthropod bite‐ or drug‐related reactions, eosinophilic cellulitis, fungal skin infections, and suppurative folliculitis.…”

Eosinophilic pustular folliculitis post chemotherapy in a patient of non-hogkins lymphoma: A case report

“…These factors cause selective migration of eosinophils and lymphocytes to the hair follicles. [ 15 ] In view of pruritus, edema, tissue eosinophilia and presence of degranulated mast cells around hair follicles, it has been proposed that mast cells may play an important part in the pathogenesis of EPF. [ 3 ] Although considered to be a sterile folliculitis, infective etiology has also been proposed as one of the mechanisms of occurrence in only one study.…”