Eosinophilic pustular folliculitis (Ofuji's disease) with response to dapsone therapy

The case records of 23 patients with classic eosinophilic pustular folliculitis (EPF), or Ofuji's disease, seen at the National Skin Centre in Singapore, from 1990 to 2001 were reviewed. All patients had clinical and histopathological findings consistent with EPF. There were eight men and 15 women (ratio 1:1.6). The mean age at presentation was 35 years. There was a marked predilection for Chinese patients (87%), with a racial distribution of 20:2:1 of Chinese, Malay and Indian patients, respectively. The most frequent site of occurrence was the face, particularly over both cheeks. The majority of patients (90%) treated with oral indomethacin had a good response within 2-4 weeks. Relapses were frequent in 82.6% of patients and maintenance with indomethacin or ketoprofen was beneficial. Eosinophilic pustular folliculitis is a rare but important disease entity presenting with recurrent indurated erythematous papulopustules and plaques on the face. Increased awareness of this condition is important as it can mimic many other conditions presenting as red plaques on the face.

show abstract

“…Dapsone has been used successfully in several reports [3][4][5]9,16 but our data showed that it was effective in only one out of four patients.…”

Section: Discussionmentioning

confidence: 57%

Eosinophilic pustular folliculitis (Ofuji's disease) in Singapore: A review of 23 adult cases

2003

View full text Add to dashboard Cite

show abstract

“…These include antibiotics [2], local and systemic corticosteroids [2], dapsone [2][3][4], isotretinoin [4,5] as well as UVB phototherapy [6]. Several case re ports described a successful control of the disease by indomethacin [7][8][9].…”

Section: Discussionmentioning

confidence: 99%

“…Eosinophilic pustular folliculitis (EPF) was first de scribed by Ise and Ofuji 111 in 1965 and is characterized by the following clinical symptoms: recurrent crops of sterile follicular pustules and papulopustules predominantly in seborrheic skin areas, annular and serpiginous plaques due to centrifugal extension and central clearing of the lesions, resolution with hyperpigmentation, absence of systemic symptoms, intermittent exacerbations with associated peripheral leukocytosis and eosinophilia, and pronounced difficulties in therapeutic management [2][3][4][5][6][7][8][9]. The distinc tive histological feature of the disease is a predominantly eosinophilic infiltrate of the hair follicles.…”

Section: Introductionmentioning

confidence: 99%

Eosinophilic Pustular Folliculitis: Successful Treatment with Interferon-Alpha

et al. 1995

View full text Add to dashboard Cite

Eosinophilic pustular folliculitis (Ofuji’s disease) is a rare skin disease of unknown etiology characterized by infiltrated circinate plaques with sterile follicular pustules in primarily seborrheic areas. Several therapeutic regimens have been reported to control the disease with inconsistent results. We here report on a patient with Ofuji’s disease, who was successfully treated with interferon-α2b.

show abstract

“…Treatment The treatment of choice is UVB irradiation, because local corticosteroids and antihistamines often fail, but dapsone can be successful also [9,10].…”

Section: Eosinophilic Pustular Folliculitismentioning

confidence: 99%

AIDS and itch

Hulsebosch

1992

Acad Dermatol Venereol

View full text Add to dashboard Cite

The complaint of itch is common in patients with AIDS and HIV infection. Inspection of the skin often reveals a dermatosis, but precise diagnosis is not always easy which makes it difficult for effective treatment. In HIV-positive patients with itch, as well as common dermatoses, one often has to deal with atypical and even new skin diseases. Many of these are papular, papulo-vesicular or papulo-pustular. This article is a protocol for the diagnosis and treatment of itch in these patients.

show abstract

Eosinophilic pustular folliculitis (Ofuji's disease) with response to dapsone therapy

Cited by 12 publications

References 0 publications

Eosinophilic pustular folliculitis (Ofuji's disease) in Singapore: A review of 23 adult cases

Eosinophilic pustular folliculitis (Ofuji's disease) in Singapore: A review of 23 adult cases

Eosinophilic Pustular Folliculitis: Successful Treatment with Interferon-Alpha

AIDS and itch

Contact Info

Product

Resources

About