Eosinophilic myositis with eosinophilic cellulitislike skin lesions. Association with increased serum levels of eosinophil cationic protein and interleukin-5

Trueb, R. M.

doi:10.1001/archderm.133.2.203

Cited by 20 publications

(23 citation statements)

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“…Increased interleukin-5 levels have been observed, which mobilizes eosinophils from the bone marrow and facilitates their homing to the skin (12)(13)(14). Interleukin (lL)-5 also increases CD25, part of the lL-2 receptor, which promotes degranulation of the eosinophils.…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic Cellulitis (Wells’ Syndrome) in Association with Angioimmunoblastic Lymphadenopathy

Renner¹,

Kauer²,

Treudler³

et al. 2007

Acta Derm Venereol

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Eosinophilic cellulitis (Wells' syndrome) is an uncommon inflammatory disease with clinical polymorphism. It is often associated with infectious, allergic or myeloproliferative diseases; however, the exact aetiology is unknown. This report describes a rare case of eosinophilic cellulitis in association with angioimmunoblastic lymphadenopathy. The typical skin findings of Wells' syndrome disappeared completely following chemotherapy and autologous stem cell transplantation.

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Section: Discussionmentioning

confidence: 99%

Eosinophilic Cellulitis (Wells’ Syndrome) in Association with Angioimmunoblastic Lymphadenopathy

Renner¹,

Kauer²,

Treudler³

et al. 2007

Acta Derm Venereol

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“…Eosinophilic cellulitis (Wells’ syndrome) is characterized by massive infiltration of the dermis with eosinophils with a ‘flame figures’ pattern, peripheral blood eosinophilia [16], and increased levels of eosinophil cationic protein and IL-5 [17]. Wells’ syndrome may be associated with drugs, infections, autoimmune disease and malignancies.…”

Section: Discussionmentioning

confidence: 99%

Chronic Paraneoplastic Cutaneous Syndrome Preceding an Indolent Variant of Mantle Cell Lymphoma: Favorable Response to Rituximab

Nemets¹,

Ronen

Lugassy³

2006

Acta Haematol

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Mantle cell lymphoma (MCL) is an aggressive type of malignant lymphoma with short median survival despite conventional therapy. We describe the unusual case of a 66-year-old man with a chronic skin rash which preceded the occurrence of an indolent MCL by 2 years. Repeated skin biopsies did not show involvement by the lymphoma. Short therapy with rituximab resulted in the complete and lasting resolution of the cutaneous lesions.

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“…Weitere Autoren beschrieben einen Fall von eosinophiler Myositis [20] sowie Fälle von Hypereosinophiliesyndrom [3,6] und erhöhten IL-5-Spiegeln. In einem Fall [20] zeigte sich, wie auch bei unserer Patientin, eine Erhöhung des ECP-Spiegels im Serum.…”

Section: Tabelle 1 Immunphänotypisierung Der Peripheren Lymphozyten Dunclassified

“…In einem Fall [20] zeigte sich, wie auch bei unserer Patientin, eine Erhöhung des ECP-Spiegels im Serum.…”

Section: Tabelle 1 Immunphänotypisierung Der Peripheren Lymphozyten Dunclassified

Eosinophile Zellulitis (Wells-Syndrom)

Plötz¹,

Abeck²,

Behrendt³

et al. 2000

Der Hautarzt

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Eosinophilic cellulitis (Wells' syndrome) is a rare disorder characterized clinically by recurrent erythematous plaques resembling cellulitis and histologically by a dermal infiltrate of lymphocytes, eosinophils and eosinophil debris between collagen bundles, forming flame figures in typical cases. A 71-year-old woman with Wells' syndrome with blood and bone marrow eosinophilia showed a good response to dapsone. The level of eosinophil cationic protein (ECP) in serum was elevated. Immunophenotyping of peripheral T cells revealed an increased proportion of CD3+CD4+T cells. The patients' cultured peripheral lymphocytes spontaneously released significant amounts of interleukin 5 (IL-5), but not interleukin 4 (IL-4) or interferon gamma (IFN gamma). These findings suggest that activated T cells may be involved in the pathogenesis of blood and tissue eosinophilia in this patient.

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Eosinophilic myositis with eosinophilic cellulitislike skin lesions. Association with increased serum levels of eosinophil cationic protein and interleukin-5

Cited by 20 publications

References 0 publications

Eosinophilic Cellulitis (Wells’ Syndrome) in Association with Angioimmunoblastic Lymphadenopathy

Eosinophilic Cellulitis (Wells’ Syndrome) in Association with Angioimmunoblastic Lymphadenopathy

Chronic Paraneoplastic Cutaneous Syndrome Preceding an Indolent Variant of Mantle Cell Lymphoma: Favorable Response to Rituximab

Eosinophile Zellulitis (Wells-Syndrom)

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