Eosinophilic gastroenteritis: a review

Oh, Hidemasa; Chetty, Runjan

doi:10.1007/s00535-008-2230-5

Cited by 76 publications

(69 citation statements)

References 128 publications

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“…A variety of drugs, including azathioprine (54), gemfibrozil (55), carbamazepine (56), clofazimine (57), and enalapril (58), can cause infiltration of eosinophils in the gastrointestinal tract. The patient reported no history of the use of any of these medications, and H. pylori was not present, which is also another cause of eosinophilic infiltration (6). This patient showed no eosinophilia during hospitalization, which is similar to 20% to 50% of cases of EG (1).…”

Section: A C Bsupporting

confidence: 52%

“…If the eosinophilic infiltrate occurs predominantly at the mucosal layer, the clinical manifestation usually involves nonspecific abdominal findings, such as abdominal pain, nausea, vomiting, diarrhea, fecal occult blood, anemia, and weight loss (3,5,6). According to the literature, this is the most prevalent subtype of EG; however, some have suggested the possibility of bias due to the relative ease of access to the mucosal layer when doing an endoscopic biopsy in order to confirm the presence of eosinophilia (6,7).…”

Section: Introductionmentioning

confidence: 99%

“…According to the literature, this is the most prevalent subtype of EG; however, some have suggested the possibility of bias due to the relative ease of access to the mucosal layer when doing an endoscopic biopsy in order to confirm the presence of eosinophilia (6,7).…”

Section: Introductionmentioning

confidence: 99%

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Unusual presentations of eosinophilic gastroenteritis: Two case reports

Leal

Fayad²,

Vieira³

et al. 2014

Turk J Gastroenterol

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Eosinophilic gastroenteritis is a rare disease that is characterized by eosinophil infiltration in one or multiple segments of the gastrointestinal tract. The etiology of this condition remains unknown. Eosinophilic gastroenteritis has heterogeneous clinical manifestations that depend upon the location and depth of infiltration in the gastrointestinal tract, and eosinophilia may or may not be present. This article reports two cases of eosinophilic gastroenteritis. The first is that of a 49-year-old woman with abdominal pain, ascites, eosinophilia, and a history of asthma. The second case is that of a 69-year-old male with a history of loss of appetite, belching, postprandial fullness, heartburn, and a 5-kilogram weight loss over a period of 9 months; ultimately, the patient was diagnosed with a gastric outlet obstruction due to pyloric stenosis. The rare character of eosinophilic gastroenteritis and its varied clinical presentations often lead to delayed diagnoses and complications. Case reports may help to disseminate knowledge about the disease, thereby increasing the likelihood of early diagnosis and intervention to prevent complications.

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Section: A C Bsupporting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

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Unusual presentations of eosinophilic gastroenteritis: Two case reports

Leal

Fayad²,

Vieira³

et al. 2014

Turk J Gastroenterol

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“…Under normal, nonpathologic conditions, the gastrointestinal tract is the only nonhematopoietic organ to contain eosinophils, and the cecal and appendiceal regions have the highest concentrations. 2 It is postulated that exposure of the gastrointes- tinal mucosa to antigens promotes a Th-2-mediated immune response. 3 Th-2 cells produce interleukin (IL)-4, IL-5 and IL-3 and promote the production of eosinophils as well as IgE.…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic Gastroenteritis Presenting with Severe Anemia and Near Syncope

Ekunno

Munsayac

Pelletier

et al. 2012

The Journal of the American Board of Family Medicine

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Eosinophilic gastrointestinal disorders or eosinophilic digestive disorders encompass a spectrum of rare gastrointestinal disorders that includes eosinophilic esophagitis, eosinophilic gastroenteritis, and eosinophilic colitis. Eosinophilic gastroenteritis is a rare inflammatory disease characterized by eosinophilic infiltration of the gastrointestinal tract. The clinical manifestations include anemia, dyspepsia, and diarrhea. Endoscopy with biopsy showing histologic evidence of eosinophilic infiltration is considered definitive for diagnosis. Corticosteroid therapy, food allergen testing, elimination diets, and elemental diets are considered effective treatments for eosinophilic gastroenteritis. The treatment and prognosis of eosinophilic gastroenteritis is determined by the severity of the clinical manifestations. We describe a 24-year-old woman with eosinophilic gastroenteritis presenting as epigastric pain with a history of severe iron deficiency anemia, asthma, eczema, and allergic rhinitis, and we review the literature regarding presentation, diagnostic testing, pathophysiology, predisposing factors, and treatment recommendations. (J Am Board Fam Med 2012;25:913-918.) Keywords: Case Reports, Eosinophilic Gastroenteritis, Gastrointestinal DisordersA 24-year-old nulliparous African-American woman was admitted after an episode of near syncope associated with 2 days of fatigue and dizziness. She reported gradual onset of dyspepsia over 2 to 3 months. She denied nausea, vomiting, menorrhagia, polymenorrhea, diarrhea, hematemesis, melena, or hematochezia. Her medical history was significant for allergic rhinitis, eczema, and asthma. Her surgical history was negative. She denied using tobacco or illicit drugs. She drank approximately 1 to 2 beers per month. Her family history was significant for a father with asthma and hypertension and a mother with hypertension. Her medications included inhaled fluticasone, an albuterol metered-dose inhaler, a Flovent inhaler, loratadine, and ranitidine.During examination, her height was 62 inches, weight 117 lb, and body mass index 21.44 kg/m 2 . Her heart rate was 111 beats per minute, blood pressure 121/57 mm Hg, respiratory rate 20 breaths per minute, and oral temperature of 98.6°F. She appeared acutely ill and lethargic. She was oriented to person, place, and time. She had pallor of the conjunctiva. Cardiovascular, respiratory, musculoskeletal, and neurological examinations were normal. Her abdomen was soft and nontender, without organomegaly. Rectal examination revealed brown stool that was hemoccult negative.Initial laboratory tests revealed a hemoglobin level of 5.1 g/dL (normal range, 12.0-16.0 g/dL), a hematocrit level of 17.1% (normal, 37.0% to 47.0%), a mean corpuscular volume of 66.9 fL (normal, 80.0 -98.0 fL), a red blood cell distribution width of 31.1%F (normal, 11.5-18.0%F), and a platelet count of 921,000/mm 3 (normal, 150,000 -400,000/mm 3 ). The white blood cell differential included 82% neutrophils, 5% lymphocytes, 5% monocytes, 6% eosinophils, and 2% basop...

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“…Eosinophilic gastroenteritis may emerge due to primary and secondary reasons (2). Especially, chronic myeloproliferative diseases and eosinophilic leukemia-lymphoma are among secondary reasons, and its treatment is rather different than of those due to other reasons, and it requires treatment with cytotoxic drugs.…”

mentioning

confidence: 99%

Eosinophilic gastroenteritis: The new imitator

Çağlar

2014

Turk J Gastroenterol

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Eosinophilic gastroenteritis: a review

Cited by 76 publications

References 128 publications

Unusual presentations of eosinophilic gastroenteritis: Two case reports

Unusual presentations of eosinophilic gastroenteritis: Two case reports

Eosinophilic Gastroenteritis Presenting with Severe Anemia and Near Syncope

Eosinophilic gastroenteritis: The new imitator

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