2011
DOI: 10.1016/j.jaci.2011.02.040
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Abstract: Eosinophilic esophagitis (EoE) is a clinicopathologic condition of increasing recognition and prevalence. In 2007, a consensus recommendation provided clinical and histopathologic guidance for the diagnosis and treatment of EoE; however, only a minority of physicians use the 2007 guidelines, which require fulfillment of both histologic and clinical features. Since 2007, the number of EoE publications has doubled, providing new disease insight. Accordingly, a panel of 33 physicians with expertise in pediatric a… Show more

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Cited by 1,784 publications
(2,486 citation statements)
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References 164 publications
(155 reference statements)
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“…Furthermore, the consensus provides a threshold cut‐off of 15 or more eosinophils per hpf in one or more esophageal biopsy specimens as one of the criteria for the diagnosis of EoE. In 2011, based on the evolution of published studies associating the effect of immune or antigenic response in EoE patients, the updated consensus recommendation expanded the definition of EoE to include an “immune/antigen‐mediated esophageal disease characterized by symptoms related to esophageal dysfunction and histologically by eosinophil‐predominant inflammation” 2. When comparing the number of published treatment trial studies that have demonstrated efficacy in the management of EoE, the conceptual basis for choosing a cut‐off value for the number of eosinophils per hpf to distinguish patients with historical remission is, to some degree, arbitrary.…”
Section: Discussionmentioning
confidence: 99%
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“…Furthermore, the consensus provides a threshold cut‐off of 15 or more eosinophils per hpf in one or more esophageal biopsy specimens as one of the criteria for the diagnosis of EoE. In 2011, based on the evolution of published studies associating the effect of immune or antigenic response in EoE patients, the updated consensus recommendation expanded the definition of EoE to include an “immune/antigen‐mediated esophageal disease characterized by symptoms related to esophageal dysfunction and histologically by eosinophil‐predominant inflammation” 2. When comparing the number of published treatment trial studies that have demonstrated efficacy in the management of EoE, the conceptual basis for choosing a cut‐off value for the number of eosinophils per hpf to distinguish patients with historical remission is, to some degree, arbitrary.…”
Section: Discussionmentioning
confidence: 99%
“…In addition to the resolution of clinical symptoms related to EoE, the histological determination of the peak number of esophageal eosinophils per hpf is an important outcome domain that is necessary to evaluate patients’ disease experience 2, 61. To date, while data have suggested arbitrary histological end‐points, there is no compelling empirical evidence to use as a guide for the appropriate definition of histological remission of patients with EoE.…”
Section: Discussionmentioning
confidence: 99%
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“…Eosinophilic esophagitis (EoE) is a chronic immune, antigen-mediated, disease of the esophagus characterized by symptoms related to esophageal dysfunction and significant esophageal eosinophilic infiltration 1. EoE has been described in many places throughout the World, including North America, Europe, South America, Australia, Asia, and the Middle East.…”
Section: Prevalence and Demographicsmentioning
confidence: 99%
“…Therefore, children with EoE learn to compensate through behavioral modifications in feeding patterns to prevent major symptoms such as emesis, dysphagia or esophageal food impactions. These behaviors include avoidance of large meals, avoidance of foods that have hard or lumpy textures such as meats and breads, prolonged chewing, cutting food into smaller pieces, lubricating food bites with condiments, and drinking with most bites of food 1. This emphasizes the importance of obtaining a detailed history from both children and adolescents with suspected EoE and their families to prevent a delay in diagnosis.…”
Section: Clinical Presentationmentioning
confidence: 99%