1981
DOI: 10.1001/archderm.117.7.427
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Eosinophilic cellulitis. (Well's syndrome) in a child

Abstract: Granulomatous dermatitis with eosinophilia (Well's syndrome) occurred in an 11-year-old boy. To our knowledge, eosinophilic cellulitis in a child in whom atrophic alopecia of the affect scalp later develops during the regression phase has not previously been reported. No notable effect of steroid therapy was observed. The cause of eosinophilic cellulitis is still unknown, but the presence of disseminated fibrinoid necrosis, vasculitis, eosinophilia, and a positive antinuclear factor test result might indicate … Show more

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Cited by 21 publications
(11 citation statements)
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“…23 Fever and arthralgia can be associated. 25 The cause is unknown but could be a result of a hypersensitivity reaction to an insect bite, a bacterial infection, toxocara or other parasite, drug exposure, a malignancy, or the presence of an atopic diathesis. 23,26 Secondly, the association between EC and alopecia areata, herpes gestationis, Raynaud's disease and pemphigoid, suggests an autoimmune component.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…23 Fever and arthralgia can be associated. 25 The cause is unknown but could be a result of a hypersensitivity reaction to an insect bite, a bacterial infection, toxocara or other parasite, drug exposure, a malignancy, or the presence of an atopic diathesis. 23,26 Secondly, the association between EC and alopecia areata, herpes gestationis, Raynaud's disease and pemphigoid, suggests an autoimmune component.…”
Section: Discussionmentioning
confidence: 99%
“…23,26 Secondly, the association between EC and alopecia areata, herpes gestationis, Raynaud's disease and pemphigoid, suggests an autoimmune component. 25,27 Finally, EC has been described following the lines of Blaschko, raising questions about a possible underlying genetic predisposition. 28 Characteristic laboratory findings include an eosinophilia and high IgE, 29 IL-5 and eosinophilic cation protein levels.…”
Section: Discussionmentioning
confidence: 99%
“…2 The condition may occur on different locations, preferably the extremities, trunk and the face area. 3 The clinical appearance may vary, and the lesions modify during their life cycle. 4 The clinical picture can be manifold and there are differences in the appearance in children and adults.…”
Section: Introductionmentioning
confidence: 99%
“…Systemic symptoms such as fever and arthralgia may occur. 3 Other differential diagnosis include annular granuloma, allergic contact dermatitis, chronic urticaria, drug eruptions, drug-induced bullous disorders, erysipelas, insect bites, Lyme disease or hypereosinophilic syndrome. There are reports stating an association between Wells syndrome and rare multisystem eosinophilic disorders such as Churg-Strauss syndrome and hyperoesinophilic syndrome.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, in patient with eosinophilia it is thought that IL-2 primes eosinophil degranulation [4,8]. Wells syndrome usually affects adults, but it has been known to occur in children [9,10]. Most cases are sporadic.…”
Section: Discussionmentioning
confidence: 99%