Eosinophil count is positively correlated with coronary artery calcification

Tanaka, Muhei; Fukui, Michiaki; Tomiyasu, Ki-ichiro; Akabame, Satoshi; Nakano, Koji; Yamasaki, Masahiro; Hasegawa, Goji; Oda, Y.; Nakamura, Naoto

doi:10.1038/hr.2011.191

Cited by 42 publications

(31 citation statements)

References 25 publications

(22 reference statements)

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“…Our study showed that patients with rhinitis (with or without asthma) had the highest count of peripheral eosinophils, and subjects with intermittent claudication had a higher eosinophil count than subjects without claudication in both the control and rhinitis groups (Table S2). This finding suggests that eosinophils may play a direct role in the atherosclerotic process, in agreement with previous studies . However, when the number of eosinophils was adjusted for in the analysis (data not shown), the relationship between rhinitis and PAD was confirmed, further supporting an independent role of rhinitis.…”

Section: Discussionsupporting

confidence: 90%

Rhinitis is associated with a greater risk of intermittent claudication in adults

Ferrari

Pesce

Marcon

et al. 2014

Allergy

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Section: Discussionsupporting

confidence: 90%

Rhinitis is associated with a greater risk of intermittent claudication in adults

Ferrari

Pesce

Marcon

et al. 2014

Allergy

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“…Though the direct role of eosinophils in atherogenesis remains unclear, clinical studies reveal that absolute eosinophil count, intraplaque eosinophil markers, and eosinophil-specific chemokines are associated with increased risk of CVDs (Haley et al, 2000;Kitano et al, 2017;Lee et al, 2001;Niccoli et al, 2010;Tanaka et al, 2012). While EG2 + eosinophils are considered to be absent during the atherosclerosis development according to immunohistochemistry (IHC) staining of human plaques (van Dijk et al, 2016), the occurrence of eosinophil extracellular trap was identified in human thrombosed atherosclerotic specimen by double staining of eosinophil major basic protein and citrullinated histone H3 (Pertiwi et al, 2019), which might trigger IFN-α production in pDCs.…”

Section: Eosinophilsmentioning

confidence: 99%

Type-I interferons in atherosclerosis

Chen

Tas

Winther

2019

Journal of Experimental Medicine

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The contribution of dyslipidemia and inflammation in atherosclerosis is well established. Along with effective lipid-lowering treatments, the recent success of clinical trials with anti-inflammatory therapies and the accelerated atherosclerosis in many autoimmune diseases suggest that targeting inflammation may open new avenues for the prevention and the treatment for cardiovascular diseases (CVDs). In the past decades, studies have widened the role of type-I interferons (IFNs) in disease, from antivirus defense to autoimmune responses and immuno-metabolic syndromes. While elevated type-I IFN level in serum is associated with CVD incidence in patients with interferonopathies, experimental data have attested that type-I IFNs affect plaque-residing macrophages, potentiate foam cell and extracellular trap formation, induce endothelial dysfunction, alter the phenotypes of dendritic cells and T and B lymphocytes, and lead to exacerbated atherosclerosis outcomes. In this review, we discuss the production and the effects of type-I IFNs in different atherosclerosis-associated cell types from molecular biology studies, animal models, and clinical observations, and the potential of new therapies against type-I IFN signaling for atherosclerosis.

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“…9 The association between eosinophils and coronary calcium has not been tested until now. In this issue of Hypertension Research, Tanaka M et al 10 showed the role of eosinophils in a cross-sectional study of 1363 consecutive participants with a clinical suspicion of coronary heart disease, with the aim of evaluating the relationships between the CAC score determined by multislice computed tomography and the peripheral eosinophil count, as well as major cardiovascular risk factors. They found a positive correlation between log(CAC+1) and the eosinophil count (r¼0.165, Po0.0001).…”

mentioning

confidence: 99%