Eosinophil-Associated Gastrointestinal Manifestations During OIT

Goldberg, Michael R.; Epstein-Rigbi, Naama; Elizur, Arnon

doi:10.1007/s12016-023-08974-0

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2024

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“…Hence, it remains a challenge to accurately assess the nature and number of adverse events, especially during at-home treatment. For example, gastrointestinal adverse events are particularly difficult to be defined, because they may arise in many clinical scenarios during OIT ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

Oral immunotherapy with enteric-coated capsules for allergic rhinitis caused by house dust mites

Zhang,

Xie,

Zhou

et al. 2024

Front. Allergy

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BackgroundOral immunotherapy (OIT) is a promising allergen-specific approach in the management of food allergy; however, studies on OIT for allergic rhinitis (AR) have rarely been reported. The purpose of this study is to evaluate the efficacy and safety of OIT using enteric-coated capsules for AR induced by house dust mites.MethodsA total of 49 patients with AR were enrolled, including 25 who received subcutaneous immunotherapy (SCIT) and 24 who received OIT. The clinical efficacy and safety in both groups were evaluated.ResultsAfter 1 year of treatment, both SCIT and OIT demonstrated significant therapeutic effects. OIT was found to be more effective than SCIT in reducing the total AR symptom score and improving the results of nasal provocation tests. Local and systemic adverse reactions were observed in the SCIT group, while none were reported in the OIT group.ConclusionOIT is an effective and safe treatment for mite-induced AR.

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Section: Discussionmentioning

confidence: 99%