Enzymeless biosensor based on β-NiS@rGO/Au nanocomposites for simultaneous detection of ascorbic acid, epinephrine and uric acid

Muthukumaran, P.; Sumathi, C.; Wilson, J.; Ravi, G.

doi:10.1039/c6ra19921f

Cited by 25 publications

(7 citation statements)

References 62 publications

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“…However, in vivo situations are far complex than buffer solutions, with the presence of over thousand-fold higher concentrations of interferent molecules. AA and UA, which share similar electrochemical profiles with adrenaline, represent two major interferents with 60 μM AA and 250 μM UA in human blood . We mimicked the in vivo situation and evaluated the sensor performance with the coexistence of these two major interferents at high concentrations.…”

Section: Resultsmentioning

confidence: 99%

“…AA and UA, which share similar electrochemical profiles with adrenaline, represent two major interferents with 60 μM AA and 250 μM UA in human blood. 31 We mimicked the in vivo situation and evaluated the sensor performance with the coexistence of these two major interferents at high concentrations. Figure 3b-ii shows the increased CV responses due the high background electrochemical reaction from AA and UA.…”

Section: Integrated Electrochemical Sensing Of the Fibermentioning

confidence: 99%

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Shape-Memory-Alloys Enabled Actuatable Fiber Sensors via the Preform-to-Fiber Fabrication

Sato

Guo

2023

ACS Appl. Eng. Mater.

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Integrative actuators and sensors within a single active device offer compelling capabilities in developing robotics, prosthetic limbs, and minimally invasive surgical tools. However, instrumenting smart and active devices with miniaturized sizes for easy customizability and high yield is largely restricted by the current manufacturing technologies. Here, we report the development of flexible polymer-based actuatable fiber sensors, produced by the preform-to-fiber thermal drawing process. It has both mechanical actuation realized by the incorporated shape-memory alloy (SMA) wires and biochemical sensing provided by carbon-based composite materials. The tip of such a fiber could be actuated with a high spatiotemporal resolution by the shape-memory effect. And, its integrated carbon composite exhibits intrinsically high sensitivity toward electroactive molecules. Here, we showed it can selectively detect adrenaline as low as 100 nM with the coexistence of major interferent molecules. We succeeded in using such an actuatable fiber sensor to target the bifurcated vessel model and capture the localized adrenaline information. The actuatable fiber sensor technologies developed here can greatly push the technological advancement in the soft and flexible robotic fields to include additional functions on top of their pure mechanical behaviors and open possibilities for achieving closed-loop control for high-precision operations.

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Section: Resultsmentioning

confidence: 99%

Section: Integrated Electrochemical Sensing Of the Fibermentioning

confidence: 99%

Shape-Memory-Alloys Enabled Actuatable Fiber Sensors via the Preform-to-Fiber Fabrication

Sato

Guo

2023

ACS Appl. Eng. Mater.

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“…As even 100 repeated continuous electrochemical cycles in 0.1 mM RF solution ( Figure 9 A) do not modify the film stability and do not cause leaching of the adsorbed RF, it can be concluded that RF strongly oxidizes the modified electrode surface. 37 , 38 Moreover, the contact of the modified electrode with air does not cause loss of electroactivity. The strong binding is believed to be due to the P–P interaction of the aromatic ring, as well as the NH group of RF with Gd 2 O 3 nanosheets deposited on the modified electrode.…”

Section: Resultsmentioning

confidence: 99%

Fabrication of Gd₂O₃ Nanosheet-Modified Glassy Carbon Electrode for Nonenzymatic Highly Selective Electrochemical Detection of Vitamin B2

et al. 2020

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A novel Gd 2 O 3 nanosheet was synthesized by the template-free chemical coprecipitation method. Interestingly, upon calcination at 600 °C, nanoparticles were transformed into a nanosheet, as observed from field emission scanning electron microscopy (FESEM) images. An increase in the calcination temperature to 600 °C increases the particle size to 50 nm, which results in aggregation. A sheetlike Gd 2 O 3 exhibits superparamagnetism from 300 K. The highly selective nonenzymatic sensing of riboflavin (RF) was studied using a modified glassy carbon electrode with Gd 2 O 3 nanosheets, and its various applications were made possible by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The redox behavior of the RF was determined. The newly fabricated sensor showed high sensitivity, stability, and reproducibility and was also tested with a commercial vitamin B2 tablet and a milk powder sample.

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“…Further, the gold nano‐spheres were deposited electrochemically. The fabricated electrode had a linear response in the range 900 nM–100 μM and 100 nM–1.0 mM with limits of detection of 331 nM and 4.5 nM for AA and UA, respectively …”

Section: Sensors and Biosensorsmentioning

confidence: 99%

Electrochemical Sensors and Biosensors Based on Graphene Functionalized with Metal Oxide Nanostructures for Healthcare Applications

et al. 2019

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Graphene has attracted wide consideration in recent years to the assembly of sensitive sensors and biosensors due to its unique and remarkable physical and electrochemical properties. Moreover, graphene, as an essential two‐dimensional carbon material with remarkably high quartz and electronic superiority, has also received significant research attention. This review presents the different synthesis techniques of graphene; graphene functionalized based electrochemical sensors and biosensors for various health care appellations. Further, were discussed on the basis of enhanced catalytic activity, improved detection limit in conjunction with sensitivity, and selectivity. Synergistic action of graphene and metal oxide nanostructure has contributed towards high activity as a biosensing material. The results with different sensors and biosensors for the detection of significant biomarkers such as protein sensor, electrochemical immune sensor, phytochrome sensor, cholesterol biosensor glucose, hydrogen peroxide, and nicotinamide adenine dinucleotide detection sensor etc., and highlighted the use of graphene and functionalized graphene in different sensing platforms. Finally, the challenges related to less aggregated graphene‐based electrochemical sensors and biosensors as well as future research directions are discussed.

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Enzymeless biosensor based on β-NiS@rGO/Au nanocomposites for simultaneous detection of ascorbic acid, epinephrine and uric acid

Abstract: In this study, marigold flower-like self-assembled β-NiS (nickel sulfide) nanosheets were grown on rGO (reduced graphene oxide) by a single-step hydrothermal process and then gold nanospheres (AuNS) were electrochemically deposited on the β-NiS@rGO nanostructures.

Cited by 25 publications

References 62 publications

Shape-Memory-Alloys Enabled Actuatable Fiber Sensors via the Preform-to-Fiber Fabrication

Shape-Memory-Alloys Enabled Actuatable Fiber Sensors via the Preform-to-Fiber Fabrication

Fabrication of Gd₂O₃ Nanosheet-Modified Glassy Carbon Electrode for Nonenzymatic Highly Selective Electrochemical Detection of Vitamin B2

Electrochemical Sensors and Biosensors Based on Graphene Functionalized with Metal Oxide Nanostructures for Healthcare Applications

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Enzymeless biosensor based on β-NiS@rGO/Au nanocomposites for simultaneous detection of ascorbic acid, epinephrine and uric acid

Abstract: In this study, marigold flower-like self-assembled β-NiS (nickel sulfide) nanosheets were grown on rGO (reduced graphene oxide) by a single-step hydrothermal process and then gold nanospheres (AuNS) were electrochemically deposited on the β-NiS@rGO nanostructures.

Cited by 25 publications

References 62 publications

Shape-Memory-Alloys Enabled Actuatable Fiber Sensors via the Preform-to-Fiber Fabrication

Shape-Memory-Alloys Enabled Actuatable Fiber Sensors via the Preform-to-Fiber Fabrication

Fabrication of Gd2O3 Nanosheet-Modified Glassy Carbon Electrode for Nonenzymatic Highly Selective Electrochemical Detection of Vitamin B2

Electrochemical Sensors and Biosensors Based on Graphene Functionalized with Metal Oxide Nanostructures for Healthcare Applications

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Fabrication of Gd₂O₃ Nanosheet-Modified Glassy Carbon Electrode for Nonenzymatic Highly Selective Electrochemical Detection of Vitamin B2