Enzyme promiscuity: first protein-catalyzed Morita–Baylis–Hillman reaction

Lipase-Catalyzed Synthesis of Indolyl 4H-Chromenes via a Multicomponent Reaction in Ionic Liquid

“…Enzyme catalytic promiscuity is the "hidden skill" of the enzyme to catalyze different type of organic reactions [18][19][20][21][22][23][24][25]. This useful enzyme property makes it possible to catalyze multistep reactions in a multicomponent reaction (MCR).…”

A mild and efficient Dakin reaction mediated by lipase

“…Lipase is one of the most popular biocatalysts in this research area due to its excellent catalytic performance in many kinds of reactions (Aldol reaction, Morita-Baylis-Hillman reaction, Mannich reaction, Henry reaction, Markovnikov addition, Michael addition, Hantzsch reaction, etc.) (3)(4)(5)(6)(7)(8)(9). Over the past few years, many reports have demonstrated that lipase could mediate the in situ generation of peracids through a perhydrolysis of carboxylic acids or esters (10)(11)(12).…”

A domino reaction for the synthesis of 2-amino-4 H -chromene derivatives using bovine serum albumin as a catalyst

“…A c c e p t e d M a n u s c r i p t 3 catalyze the tandem Kemp elimination/β-elimination reaction [22]. In 2007, Reetz and co-workers described that BSA could promote the Morita-Baylis-Hillman (MBH) reaction of 4-nitrobenzaldehyde with cyclohexenone affording the product with a certain degree of enatioselectivity [23]. In 2011, Gotor and co-workers discovered that BSA had the ability to catalyze the Henry reaction between aromatic aldehydes and 1-nitroalkanes in aqueous medium [24].…”