Enzyme Flexibility in Drosophila melanogaster

Gibson, J. B.

doi:10.1038/227959a0

Cited by 184 publications

(134 citation statements)

References 13 publications

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“…This difference is also shown in other populations of Drosophila melanogaster (Gibson, 1970;Ward, 1975;Oakeshott, 1976). Genetical variation for ADH activity in the "Texas" population is also manifest amongst lines of the same electromorph, indeed there is about a two-fold difference between the highest and lowest ADH activities whether the flies are of the AdhS'S or Adh' genotype Birley and Barnes 1975).…”

Section: Dxscussiosupporting

confidence: 53%

“…the difference between ADH-F and ADH-S is adaptive in the presence of alcoholic substrates in the food medium (Gibson 1970;Bijlsma-Meeles and Van Delden, 1974;Briscoe, Robertson and Malpica, 1975;Morgan, 1975;Oakeshott, 1976) and can be attributed to the catalytic efficiencies of these enzymes (Day, Hillier and Clarke, 1974;Clarke, 1975). The causes and adaptive strategies for the genetical variation at modifier loci are less well understood and may well be manifold.…”

Section: Dxscussiomentioning

confidence: 99%

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Genetical variation for enzyme activity in a population of Drosophila Melanogaster

Barnes

Birley

1978

Heredity

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SUMMARYChromosome substitution lines derived from two inbred strains of Drosophila nselanogaster homozygous for the AdIj allele of alcohol dehydrogenase but differing significantly in ADH activity have been analysed. Variation in activity can be attributed to all three major chromosomes. The effect of the second chromosome, where the ADH structural gene is located, can be modified significantly by the genotype of both the first and the third chromosomes. The most substantial single effect results from homozygous differences between the third chromosomes. In contrast, differences between the X chromosomes are revealed only when the second or second and third chromosomes are heterozygous.

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Section: Dxscussiosupporting

confidence: 53%

Section: Dxscussiomentioning

confidence: 99%

Genetical variation for enzyme activity in a population of Drosophila Melanogaster

Barnes

Birley

1978

Heredity

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“…We think it unsafe to draw allele homologies between the allele types in the island and continental forms since the most commonly occurring allele in the widely-separated geographic populations may not be the same. Gibson (1970) has provided evidence why we might expect to see differences in allele frequencies at this locus. Vigue and Johnson (1973) have demonstrated significant differences in allele frequencies which demonstrate a North-South cline.…”

Section: Drosophila Simulans Variabilitymentioning

confidence: 99%

Electrophoretic variability in island populations of Drosophila simulans and Drosophila immigrans

1976

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“…Several multi-generation experiments have suggested that F, which produces at least twice the ADH activity of S, reaches higher equilibrium frequencies in populations kept on ethanol impregnated food than in those kept on food without added ethanol (van Delden, 1982 for a review). But once again the total experimental results are ambiguous; Gibson and Oakeshott (1982) have pointed out that higher F frequencies have generally only been obtained with populations which have spent at least a year in the laboratory prior to the experiment (Gibson, 1970;Bijlsma-Meeles and van Delden, 1974;van Delden eta!., 1978;Oakeshott, 1979;Cavener and Clegg, 1981;Vigue et a!., 1982).…”

Section: Introductionmentioning

confidence: 99%

Selective effects of the genetic background and ethanol on the alcohol dehydrogenase polymorphism in Drosophila melanogaster

1984

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SUMMARYEight freshly caught Australasian mass collections ranging in Adh F frequency from 4 to 96 per cent were each divided into eight selection lines. Two selection lines from each base population were put on one of four types of mediumstandard food supplemented with 0 per cent, 3 per cent, 6 per cent or 9 per cent ethanol. After 30 generations the tolerance of 6 per cent and 9 per cent selection lines on a test dose of 9 per cent ethanol was greater than that of the 0 per cent lines on this dose. The tolerance of the 3 per cent lines on this dose was less than that of the 0 per cent lines. There were no significant differences in the tolerance responses across the eight base populations but in only one did Adh frequencies diverge among the four ethanol selection environments: F frequencies in the Brisbane 9 per cent lines were higher than in the Brisbane 0 per cent, 3 per cent and 6 per cent lines. Although the selection affecting Adh did not generally differ among the four selection environments, it differed highly significantly among the eight base populations. The equilibrium F frequencies predicted from the maximum likelihood estimates of the selection coefficients were in close agreement with the frequencies observed in the original collections. The only aspect of the coefficients which was consistent across base populations was FS heterozygote superiority.

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Enzyme Flexibility in Drosophila melanogaster

Cited by 184 publications

References 13 publications

Genetical variation for enzyme activity in a population of Drosophila Melanogaster

Genetical variation for enzyme activity in a population of Drosophila Melanogaster

Electrophoretic variability in island populations of Drosophila simulans and Drosophila immigrans

Selective effects of the genetic background and ethanol on the alcohol dehydrogenase polymorphism in Drosophila melanogaster

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