Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products

Abstract

Pericyclic reactions are powerful transformations for the construction of carbon-carbon and carbon-heteroatom bonds in organic synthesis. Their role in biosynthesis is increasingly apparent, and mechanisms by which pericyclases can catalyse reactions are of major interest 1. [4+2] cycloadditions (Diels-Alder reactions) have been widely used in organic synthesis 2 for the formation of six-membered rings and are now well-established in biosynthesis 3-6. [6+4] and other 'higher-order' cycloadditions were predicted 7 in 1965, and are now increasingly common in the laboratory despite challenges arising from the generation of a highly strained ten-membered ring Reprints and permissions information is available at http://www.nature.com/reprints.

Structural glycobiology in the age of electron cryo-microscopy

“…An overview of results is presented in Figure 2 (adapted with permission from IUCr Journals). The tool has received positive adoption by the community, as evidenced by its use on several high-profile X-ray and cryo-EM structures with abundant protein N-glycosylation [24][25][26][27].…”

Rhizolutin, a Novel 7/10/6‐Tricyclic Dilactone, Dissociates Misfolded Protein Aggregates and Reduces Apoptosis/Inflammation Associated with Alzheimer's Disease

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Interrogating chemical mechanisms in natural products biosynthesis using quantum chemical calculations

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