Enzymatic Degradation of Poly(butylene succinate) Copolyesters Synthesized with the Use of Candida antarctica Lipase B

Wcislek, Aleksandra; Sonseca, Águeda; McClain, Andrew; Piegat, Agnieszka; Sobolewski, Peter; Puskás, Judit E.; Fray, Mirosława El

doi:10.3390/polym10060688

Cited by 48 publications

(53 citation statements)

References 35 publications

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“…8,11 By varying the PBS to DLA or DLA-OH (hard to soft segment) ratio, poly(butylene succinate- co -butylene dilinoleate) (PBS-DLA) or poly(butylene succinate-dilinoleic succinate) copolymers, covering a wide range of mechanical properties and degradation rates, can be synthesized. 10,12…”

Section: Introductionmentioning

confidence: 99%

Bone Healing in the Presence of a Biodegradable PBS-DLA Copolyester and Its Composite Containing Hydroxyapatite

et al. 2019

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The healing process of the fractured bone in a presence of poly(butylene succinate-butylene dilinoleate) (PBS-DLA) copolymer containing nanosized hydroxyapatite (HAP) particles has been investigated. The PBS-DLA material containing PBS hard segments and DLA soft segments (50:50 wt %) was used to prepare a polymer/ceramic composite with 30 wt % HAP. A new PBS-DLA copolymer showed a high elasticity of 500% and 15 MPa tensile strength. Addition of HAP improved tensile strength up to 25 MPa while high elasticity has been preserved going down only to 300% of elongation at break. A polymer nanocomposite was fabricated into small elastic polymer rods 15 mm long and 1 × 2 mm in cross section and used for tibia bone fixation in rats. Mallory trichrome staining indicated that new biodegradable copolymers and its composite containing HAP have triggered the most advanced bone healing of all tested materials, thus indicating their high potential for bone tissue engineering and repair.

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Section: Introductionmentioning

confidence: 99%

Bone Healing in the Presence of a Biodegradable PBS-DLA Copolyester and Its Composite Containing Hydroxyapatite

et al. 2019

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“…It can be concluded that these copolyesters comprising two different segments show different crystalline structures and crystal forms, thus affecting polymer properties, including susceptibility to degradation. Indeed, in earlier work where two PBS-DLS copolyesters were synthesized using enzyme as the catalyst, different spherulitic morphology was observed after degradation [32].…”

Section: Structural Characteristics With Waxs Analysismentioning

confidence: 99%

Bio-Copolyesters of Poly(butylene succinate)(PBS) Containing Long Chain Bio-Based Glycol

Stępień

Miles

McClain

et al. 2019

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Graphical AbstractAbstract Poly(butylene succinate) (PBS) is a thermoplastic and biodegradable polyester characterized by high rigidity due to its high crystallinity. However, the use of long chain biobased monomers to produce segmented copolymers is an effective strategy to tailor the properties of PBS, such as greater flexibility. In this paper, a series of aliphatic bio-copolyesters of poly(butylene succinatedilinoleic succinate) (PBS-DLS) were successfully synthesized via a direct two-step polycondensation method using a semi-pilot scale reactor for melt polymerization and titanium dioxide/silicon dioxide coprecipitate catalyst (C-94). In this study, the thermal and mechanical properties were investigated and compared, focusing on the effect of varying the amount of biobased dilinoleic diol in the structure. With increasing amount of long chain diol, an increase in molecular weight, density, and melt flow index was observed. The semicrystalline nature of the copolymers was confirmed using differential scanning calorimetry (DSC) and dynamic mechanical thermal analysis (DMTA) methods. These copolymers exhibit two main transition temperatures and vary in softness and processing flexibility. Furthermore, in the DSC data a linear trend was observed with increasing wt.% of hard PBS segments, which can be described by the Gordon-Taylor equation. Increasing the soft DLS segment content in the copolymer series resulted in an increase in the elastic behavior of the polymers. The broad range of crystallization temperatures and melt flow index values indicates that a polyester library with customizable properties that spans PBS applications has been successfully obtained. KEY WORDSpoly(butylene succinate), polycondensation, titanium dioxide, thermal properties, mechanical tests Recent research has focused on the synthesis of "green" polymers: biodegradable polymers that are derived from renewable resources, offering much improved sustainability [8][9][10]. Of particular interest is the aliphatic polyester poly(butylene succinate) (PBS) [11], that was "rediscovered" in the early 90's and commercialized by Mitsubishi Chemicals Corporation and Showa-Denko under trademark Bionolle TM . Due to its susceptibility to decomposition, ease of processing, and durability, PBS is widely investigated for use in biomaterials, including tissue engineering [12]. Further, incorporating PBS as a building block in copolymer synthesis is a versatile strategy towards tailoring its properties and obtaining materials with a two-domain crystalline and amorphous structure [13,14]. Therefore, to understand the structure-property relationship of these new materials, it is necessary to study their crystal structures, thermal properties, and mechanical behavior.To tailor the advantageous properties of PBS for use in various applications, including biomedicine, the amount of PBS introduced during polymer synthesis can be systematically varied, yielding materials that range from soft and rubber-like to stiff and mechanically stable [15][16][17]. Many e...

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“…An interesting example of condensation copolyesters are segmented block or random copolymers containing alcohols or acids derived from long chain fatty acids which are endogenous to human body [58]. Many studies have proven that polyesters containing either terephthalic acid (PET) or poly(butylene succinate)(PBS) are biocompatible and exhibit good mechanical properties for soft tissue engineering applications [59][60].…”

Section: Synthetic Bioelastomersmentioning

confidence: 99%

Bio-Inspired Polymer-Polymer Hybrids for Medical Applications

Demirci¹,

Niedźwiedź²,

Kantor-Malujdy³

et al. 2021

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Novel bio-inspired materials have gained recently great attention, especially in medical applications. Applying sophisticated design and engineering methods, various polymer-polymer hybrid systems with outstanding performance have been developed in last decades. Hybrid systems composed of bioelastomers and hydrogels are very attractive due to their high biocompatibility and elastic nature for advanced biomaterials used in various medical applications such as drug delivery systems and scaffolds for tissue engineering. Herein, we describe the advances in current state-of-the-art design, properties and applications of polymer-polymer hybrid systems in medical applications. Bio-inspired functionalities, including bioadhesiveness, injectability, antibacterial properties and degradability applicable to advanced drug delivery systems and medical devices will be discussed in a context of future efforts towards development of bioinspired materials.

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Enzymatic Degradation of Poly(butylene succinate) Copolyesters Synthesized with the Use of Candida antarctica Lipase B

Cited by 48 publications

References 35 publications

Bone Healing in the Presence of a Biodegradable PBS-DLA Copolyester and Its Composite Containing Hydroxyapatite

Bone Healing in the Presence of a Biodegradable PBS-DLA Copolyester and Its Composite Containing Hydroxyapatite

Bio-Copolyesters of Poly(butylene succinate)(PBS) Containing Long Chain Bio-Based Glycol

Bio-Inspired Polymer-Polymer Hybrids for Medical Applications

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