Environmental Risk Factors for Persistent Asthma in Lucknow

Awasthi, Sanjay; Gupta, Saurabh; Maurya, Nutan; Tripathi, Priya; Dixit, Pratibha; Sharma, Neeraj

doi:10.1007/s12098-012-0817-6

Cited by 22 publications

(26 citation statements)

References 20 publications

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“…Intense truck traffic was considered present when truck traffic was reported almost the whole day and this was consistent with other studies [28]. …”

Section: Methodssupporting

confidence: 88%

Association between environmental factors and current asthma, rhinoconjunctivitis and eczema symptoms in school-aged children from Oropeza Province – Bolivia: a cross-sectional study

Solis-Soto¹,

Patiño

Nowak

et al. 2013

Environ Health

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BackgroundIn recent years, the prevalence of asthma, rhinoconjunctivitis and eczema symptoms in childhood has considerably increased in developing countries including Bolivia, possibly due to changes in lifestyle, environmental and domestic factors. This study aimed to assess the association between environmental factors and asthma, rhinoconjuctivitis and eczema symptoms in school-aged children from Oropeza Province in Chuquisaca, Bolivia.MethodsA cross-sectional study was performed in 2340 children attending the fifth grade in 36 randomly selected elementary schools in Oropeza province. The prevalence of symptoms was determined using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Environmental factors were assessed by the ISAAC environmental questionnaire including questions related to exposure to pets, farm animals, indoor and outdoor pollution, presence of disease vectors at home and precarious household conditions. Generalized linear mixed-effects models were adjusted for age, sex and place of living.ResultsThirty seven percent of children reported that at least one of their parents smoked at home. Wood or coal was used as cooking fuel in 19% of the homes and 29% reported intense truck traffic on the street where they lived. With respect to hygiene conditions, 86% reported exposure to dogs, 59% exposure to cats and 36% regular contact to farm animals. More than one precarious household condition was reported by 8% of children. In the adjusted model exposure to dog (adjusted OR 1.4; CI 95% 1.0-1.9), cat (1.2; 1.0-1.5), farm animals (1.5; 1.2-1.8); intense truck traffic (1.3; 1.0-1.6), parents smoking at home (1.2; 1.0-1.5), presence of disease vectors at home (fourth quartile vs. first quartile: 1.6; 1.2-2.3) and two or more precarious household conditions (1.5; 1.0-2.2) were significantly associated with rhinoconjunctivitis symptoms. The associations were similar for asthma and eczema symptoms; however it did not reach the level of statistical significance for all items.ConclusionOur results support previous findings reported for poor communities especially in Latin America, showing that lower hygiene conditions did not have protective effect against asthma and rhinoconjunctivitis and eczema symptoms.

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“…Intense truck traffic was considered present when truck traffic was reported almost the whole day and this was consistent with other studies [28]. …”

Section: Methodssupporting

confidence: 88%

Association between environmental factors and current asthma, rhinoconjunctivitis and eczema symptoms in school-aged children from Oropeza Province – Bolivia: a cross-sectional study

Solis-Soto¹,

Patiño

Nowak

et al. 2013

Environ Health

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show abstract

“…[22] In this study, we found persistent asthma to be statistically significantly associated with previous use of bronchodilators and lower pulmonary function in comparison to intermittent asthma.…”

Section: Discussionmentioning

confidence: 49%

“…However, our recent original article reported statistically significant association between persistent asthma and uncontrolled asthma. [22] (b) Our objective was to assess the association of CRHR1 gene polymorphism with persistent asthma, not with the occurrence of asthma; therefore, we did not recruit healthy controls. Nonetheless, further case-control studies with a larger sample size and with long-term follow-up will undoubtedly strengthen the role of the CRHR1 gene polymorphism in childhood asthma.…”

Section: Discussionmentioning

confidence: 99%

Association of Corticotrophin Releasing Hormone Receptor 1 Gene Polymorphisms (Rs242941 and Rs242939) With Persistent Asthma and Its Phenotype in Northern Indian Asthmatic Children: A Cross‑sectional Study

et al. 2016

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“…In another study, a significant repetition of G542X mutation had been observed among cases when compared with controls; nevertheless, only G551D was mainly related to asthma risk, but G542X showed no association with asthma. 1 Another interesting point in our work is the clear link between individuals with single W1282X mutation and the increased risk of recurrent chest infection and bronchiectasis; moreover, probands with double mutations (36 cases, 59%) were at increased risk for severe symptoms, earlier onset of symptoms, higher incidence of complications, and increased frequency of hospital admissions. This observation can be considered as specific pulmonary phenotype of CFTR-related disorders.…”

Section: Discussionmentioning

confidence: 71%

“…CFTR is a 230-kb gene located on chromosome 7 encoding a 1,480-amino acid polypeptide, which functions as a chloride channel in the epithelial membrane. 1 Bronchial asthma is a complex respiratory disorder characterized by marked heterogeneity in disease triggers and response to therapy. 2 The interaction of genetic, environmental, and host factors may contribute to the development of childhood asthma and defines its progress, including persistence and severity.…”

Section: Introductionmentioning

confidence: 99%

Screening for the Most Common Mutations of CFTR Gene among Egyptian Children with Difficult-to-Treat Asthma

et al. 2020

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Cystic fibrosis (CF) is panethnic autosomal recessive disease that affects the exocrine glands of pancreas, lungs, and intestine. It is often misdiagnosed in developing countries as difficult-to-treat asthma. We enrolled 150 Egyptian families with one or more probands who were complaining of difficult-to-treat asthma, and 112 cases were studied extensively through history taking including pedigree construction and clinical examination. In addition, spirometry and computed tomography of the chest were done in selected cases. All cases were subjected to quantitative sweat chloride test and molecular screening for the three most common mutations of cystic fibrosis transconductance regulator (CFTR) gene (ΔF508, G542X, W1282X) using amplification refractory mutation system (ARMS) technique. Probands of difficult-to-treat asthma comprised 66 males and 46 females; their age range was 1 to 14 years. Sixty-one probands (54.5%) were carriers of one or more of the studied mutations (36 cases and 25 carriers). Six carriers of single mutations had mild respiratory symptoms and negative sweat test. The most common allele was ΔF508, 60 alleles in 56 individuals (4 were homozygous ΔF508/ΔF508) followed by W1282X in 25 individuals and G542X in 12 individuals. Allele W1282X had an increased risk of recurrent chest infection and bronchiectasis. Moreover, cases with two mutations had more severe symptoms compared with those with a single mutation. CFTR mutations and CF-related syndromes are not rare as thought in Egypt, especially among the high-risk difficult-to-treat asthma. The readily available ARMS technique is recommended for ΔF508 and/or W1282X screening on priority basis among these children.

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Environmental Risk Factors for Persistent Asthma in Lucknow

Abstract: Since patients with persistent asthma are more likely to have uncontrolled asthma and since persistent asthma is associated with residence closer to heavy traffic and exposure to second hand smoke, minimizing exposures to these may help in better asthma control.

Cited by 22 publications

References 20 publications

Association between environmental factors and current asthma, rhinoconjunctivitis and eczema symptoms in school-aged children from Oropeza Province – Bolivia: a cross-sectional study

Association between environmental factors and current asthma, rhinoconjunctivitis and eczema symptoms in school-aged children from Oropeza Province – Bolivia: a cross-sectional study

Association of Corticotrophin Releasing Hormone Receptor 1 Gene Polymorphisms (Rs242941 and Rs242939) With Persistent Asthma and Its Phenotype in Northern Indian Asthmatic Children: A Cross‑sectional Study

Screening for the Most Common Mutations of CFTR Gene among Egyptian Children with Difficult-to-Treat Asthma

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