Environmental factors potentially associated with mumps transmission in Yeshivas during a mumps outbreak among highly vaccinated students: Brooklyn, New York, 2009–2010

Fiebelkorn, Amy Parker; Rosen, Jennifer B; Brown, Cedric; Zimmerman, Christopher; Renshowitz, Hyman; D'Andrea, C.; Gallagher, Kathleen; Harpaz, Rafael; Zucker, Jane R.

doi:10.4161/hv.22415

Cited by 23 publications

(14 citation statements)

References 14 publications

(20 reference statements)

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“…In this outbreak, mumps transmission was associated with intense contact among students in religious schools, similar to the preceding outbreak in New York. 7,25 Nevertheless, the clinical disease was significantly milder among vaccinated cases. Probable contributing factors to the outbreak include insufficient vaccine effectiveness and less than optimal vaccination coverage.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of a large mumps outbreak: Clinical severity, complications and association with vaccination status of mumps outbreak cases

Stein‐Zamir

Schroeder

Shoob

et al. 2015

Human Vaccines & Immunotherapeutics

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In recent years, large mumps outbreaks, involving mainly adolescents and young adults, have re-emerged in several countries. We investigated a large mumps outbreak, evaluated the association between mumps clinical severity (complications, hospitalization) and vaccination status (number of previous measles, mumps and rubella -MMR vaccine doses), and assessed vaccine effectiveness. The first mumps cases emerged in an ultra-orthodox boys' school in Jerusalem and were epidemiologically linked to the mumps outbreak in New York. Overall, 3130 mumps cases were notified in the Jerusalem district during September 2009-August 2011 (median age 13y, 64% males). Most cases were reported from community clinics. Patients with systemic symptoms and/or complications (419, 13.4%) were either hospitalized (n D 79) or treated in an emergency medical center (n D 340). The main complications included orchitis (3.8% males> age 12y) and meningoencephalitis (0.5%). The mumps virus genotype was G5. The distribution of previous MMR vaccine doses (n D 0,1,2) was: 24.8%, 28.3% and 46.9%, respectively. The number of previous vaccine doses was inversely associated with clinical severity. Adjusted values for MMR vaccine effectiveness against complications were estimated as 52.1% (95% CI ¡4 ¡78%) for one vaccine dose and 62.7% (95% CI 25.7-81.3%) for 2 doses. The outbreak was characterized by predominance of male students; the majority of whom had been previously vaccinated. The reported complication rate was relatively low. Vaccination status was associated with age and disease severity. The combination of limited mumps vaccine effectiveness and the specific school setting (dense learning and living conditions) probably contributed to the disease spread.

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Section: Discussionmentioning

confidence: 99%

Characteristics of a large mumps outbreak: Clinical severity, complications and association with vaccination status of mumps outbreak cases

Stein‐Zamir

Schroeder

Shoob

et al. 2015

Human Vaccines & Immunotherapeutics

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“…15,16 Using a Poisson regression analysis and a case-crossover methodology, we analyzed mumps data reported to the Taiwan CDC from 2006 to 2011. We found that the incidence of mumps was highest during the summer months but that incidence was positively correlated with increased mean temperature and vapor pressure in both the long-term and acute effect analyses.…”

Section: Discussionmentioning

confidence: 99%

The association between the incidence of mumps and meteorological parameters in Taiwan

et al. 2015

Human Vaccines & Immunotherapeutics

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These authors equally contributed to this work. Keywords: infectious disease, meteorological parameters, modeling, mumps, weatherMumps is caused by a paramyxovirus. It is an acute, but mild infectious disease. However, approximately 10% of patients with mumps can develop severe meningoencephalitis, disability, and death. Seasonal patterns in mumps vary across countries, but the reasons for this phenomenon remain unclear. The aim of this study was to assess the role of meteorological factors on mumps infection. We investigated the relationships between weather variability and the incidence of mumps in Taiwan using a Poisson regression analysis and case-crossover methodology. Between 2006 and 2011, 6,612 cases of mumps were reported to the Centers for Disease Control, Taiwan (Taiwan CDC). The incidence of mumps showed a significant seasonality in summertime (for oscillation, P < 0.001). The number of mumps started to increase at temperatures of 20 C (r 2 D 0.73, P < 0.001), and the case count of mumps began to decline when the temperatures were higher than approximately 25 C (r 2 D 0.24, p D 0.04), producing an inverted V-shaped relationship. Similarly, the number of mumps began to increase at a vapor pressure of 5-9 hPa (r 2 D 0.87, P < 0.005) and decreased at a vapor pressure higher than 25-29 hPa (r 2 D 0.21, p D 0.05). The number of mumps cases was positively associated with temperature and vapor pressure in the preceding period of the infection. In conclusion, this study showed that the occurrence of mumps is significantly associated with increasing temperature and vapor pressure in Taiwan. Therefore, these factors could be regarded as warning signals indicating the need to implement preventive measures.

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“…Mumps attack rates above 10% among vaccinated university students have been reported during various recent outbreaks [ 5 , 6 ]. Those attack rates were based on a particular setting within a specific time frame, and they are therefore probably higher than overall attack rates in a nationwide outbreak.…”

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confidence: 99%

Mumps Serum Antibody Levels Before and After an Outbreak to Assess Infection and Immunity in Vaccinated Students

Gouma

Klooster

Melker

et al. 2014

Open Forum Infectious Diseases

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Background Since 2009, various mumps outbreaks have occurred in the Netherlands, affecting mostly young adults vaccinated against mumps. In this retrospective study, we estimated attack rates for symptomatic and asymptomatic mumps virus infection based on mumps-specific immunoglobulin (Ig)G concentrations in paired blood samples obtained before and after the mumps outbreaks, collected in 2 university cities. We aimed to identify a serological correlate of immune protection and risk factors for mumps virus infection.Methods Mumps-specific IgG levels were measured by Luminex technology in paired pre- and post-outbreak samples from students from Leiden (n = 135) and Utrecht (n = 619). Persons with a 4-fold increase in mumps IgG concentrations or mumps IgG concentrations >1500 RU/mL were assumed to have had a mumps virus infection.Results Attack rates for symptomatic and asymptomatic mumps virus infection were 2.0% and 3.8%, respectively. Pre-outbreak mumps-specific IgG concentrations were lower among cases than among noncases (P = .005) despite vaccination history, but no serological cutoff for immune protection could be established. Mumps among housemates was significantly associated with serological evidence for mumps virus infection (odds ratio, 7.25 [95% confidence interval, 3.20–16.40]; P < .001).Conclusions Symptomatic and asymptomatic mumps virus infections in vaccinated persons can be identified by retrospective assessment of mumps-specific IgG antibodies in blood samples.

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Environmental factors potentially associated with mumps transmission in Yeshivas during a mumps outbreak among highly vaccinated students: Brooklyn, New York, 2009–2010

Abstract: (2013) Environmental factors potentially associated with mumps transmission in Yeshivas during a mumps outbreak among highly vaccinated students: Brooklyn, New York,

Cited by 23 publications

References 14 publications

Characteristics of a large mumps outbreak: Clinical severity, complications and association with vaccination status of mumps outbreak cases

Characteristics of a large mumps outbreak: Clinical severity, complications and association with vaccination status of mumps outbreak cases

The association between the incidence of mumps and meteorological parameters in Taiwan

Mumps Serum Antibody Levels Before and After an Outbreak to Assess Infection and Immunity in Vaccinated Students

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