Environmental factors of celiac disease: Cytotoxicity of hulled wheat species Triticum monococcum, T. turgidum ssp. dicoccum and T. aestivum ssp. spelta

Abstract

The results have shown a constant and significant toxic effect of spelt wheat which is not shared by the two other ancient cereals. Future studies on celiac intestinal organ cultures are needed to increase the prospects of breeding programs aimed at developing wheat cultivars potentially tolerated by most celiac patients.

Immunogenicity of two oat varieties, in relation to their safety for celiac patients

“…Consistent with previous results [28][29], statistically significant TEER decrement was observed only after treatment for 4 h with PTG compared with treatment with medium alone (p < 0.01; Figure 1C). PT-digests from the two oat varieties were not able to induce TEER decrement ( Figure 1C), indicating that, differently from gliadin, the oats did not alter permeability.…”

“…The measurement of TEER represents a good method to assay the integrity of epithelial barrier and of the polarized CaCo-2 cell monolayer in response to several insults. It was shown that gliadin induces TEER decrement after 4 h of treatment in CaCo-2 cell monolayers [28][29].…”

Wheat and gluten in South African food products

“…These results cast doubt on the claims of the manufacturer of the spelt cakes (sample 7) that 'in laboratory experiments no gluten was isolated from the spelt cakes' (Figure 1b), and that the spelt cakes 'may be suitable for individuals who have celiac disease'. Evidence strongly suggests that spelt exerts toxic effects similar to that of common wheat in celiac disease sufferers (Vincentini et al, 2007). The buckwheat flour (sample 8) tested negative for wheat (Table 1), an anticipated result since buckwheat is not considered to be taxonomically closely related to wheat (Anand, Piris, & Truelove, 1978;FDA, 2007;Kasarda, 2001) and therefore was not expected to be recognised by wheat-specific PCR primers.…”

Variation in noxiousness of different wheat species for celiac patients

“…Earlier studies (De Vincenzi et al 1996c;Molberg et al 2005;Vincentini et al 2007) showed diploid and tetraploid hulled wheat species T. monococcum and T. turgidum ssp. dicoccum to be poor in or devoid of noxious prolamins.…”