Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
113
1

Year Published

2004
2004
2020
2020

Publication Types

Select...
6
2
1
1

Relationship

0
10

Authors

Journals

citations
Cited by 204 publications
(115 citation statements)
references
References 146 publications
1
113
1
Order By: Relevance
“…Although some uncertainty remains as to the site of Nrf2 induction mediated by tBHQ in vivo, our study nonetheless indicates that striatal-specific damage because of the systemic administration of a metabolic stressor can be strongly attenuated by this dietary strategy. Given that many neurodegenerative diseases may be triggered by exposure to diet or lungderived toxins (71)(72)(73), it is conceivable that a dietary strategy to increase antioxidant function in multiple organs may be an ideal prophylactic strategy. To our knowledge, this is the first study to show that a protective effect of a phase 2 inducer on brain function in vivo is dependent on Nrf2.…”
Section: Discussionmentioning
confidence: 99%
“…Although some uncertainty remains as to the site of Nrf2 induction mediated by tBHQ in vivo, our study nonetheless indicates that striatal-specific damage because of the systemic administration of a metabolic stressor can be strongly attenuated by this dietary strategy. Given that many neurodegenerative diseases may be triggered by exposure to diet or lungderived toxins (71)(72)(73), it is conceivable that a dietary strategy to increase antioxidant function in multiple organs may be an ideal prophylactic strategy. To our knowledge, this is the first study to show that a protective effect of a phase 2 inducer on brain function in vivo is dependent on Nrf2.…”
Section: Discussionmentioning
confidence: 99%
“…Increasing evidence indicates that the environment plays an important role in the etiology of basal ganglia pathologies, such as PD. Living in a rural area, farming, drinking well water, and occupational exposure to agricultural chemicals are all suspected PD risk factors (Gorell et al, 1998;Tanner et al, 1999;Priyadarshi et al, 2001;Di Monte et al, 2002;Brown et al, 2006). Among the risk factors for PD, pesticide exposure has received particular attention and it has been associated with increased incidence of PD in agricultural workers in rural environments (Semchuk et al, 1992;Schapira, 1999;Priyadarshi et al, 2000;Brown et al, 2006).…”
Section: Introductionmentioning
confidence: 99%
“…Neurotoxicity and neuroprotective strategies are particularly important with respect to Parkinson's disease (PD), a neurodegenerative disease caused by the selective loss of dopaminergic neurons in the midbrain. Epidemiological data and twin studies suggest that environmental toxins may be important contributors to PD (Di Monte et al, 2002;Di Monte, 2003;Tanner et al, 1999). The dopaminergic neurons of the brain seem to be especially vulnerable to toxic events, as evidenced by their susceptibility to toxic insults, including rotenone, paraquat, and manganese (Betarbet et al, 2000;Thiruchelvam et al, 2000), lipopolysaccharides (Carvey et al, 2003;Gayle et al, 2002), diesel exhaust particles (Block et al, 2004) and N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (Davis et al, 1979;Langston et al, 1983).…”
Section: Introductionmentioning
confidence: 99%