Environmental enrichment influences brain cytokine variations elicited by social defeat in mice

McQuaid, Robyn J.; Audet, Marie‐Claude; Jacobson‐Pick, Shlomit; Anisman, Hymie

doi:10.1016/j.psyneuen.2012.10.003

Cited by 43 publications

(38 citation statements)

References 45 publications

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“…33,34 In contrast, in an animal model of social defeat, EE does not change the expression levels of IL-1b, IL-1r, or TNF-a. 35 However, in the present study, the levels of inflammatory mediators did not differ significantly between the meningitis group and meningitis + EE group; thus, the prevention of cognitive damage was not associated with these parameters.…”

Section: Discussioncontrasting

confidence: 72%

Environmental enrichment restores cognitive deficits induced by experimental childhood meningitis

Barichello

Fagundes

Generoso

et al. 2014

Rev. Bras. Psiquiatr.

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Objective: To evaluate the influence of environmental enrichment (EE) on memory, cytokines, and brain-derived neurotrophic factor (BDNF) in the brain of adult rats subjected to experimental pneumococcal meningitis during infancy. Methods: On postnatal day 11, the animals received either artificial cerebrospinal fluid (CSF) or Streptococcus pneumoniae suspension intracisternally at 1 6 10 6 CFU/mL and remained with their mothers until age 21 days. Animals were divided into the following groups: control, control + EE, meningitis, and meningitis + EE. EE began at 21 days and continued until 60 days of age (adulthood). EE consisted of a large cage with three floors, ramps, running wheels, and objects of different shapes and textures. At 60 days, animals were randomized and subjected to habituation to the open-field task and the step-down inhibitory avoidance task. After the tasks, the hippocampus and CSF were isolated for analysis. Results: The meningitis group showed no difference in performance between training and test sessions of the open-field task, suggesting habituation memory impairment; in the meningitis + EE group, performance was significantly different, showing preservation of habituation memory. In the step-down inhibitory avoidance task, there were no differences in behavior between training and test sessions in the meningitis group, showing aversive memory impairment; conversely, differences were observed in the meningitis + EE group, demonstrating aversive memory preservation. In the two meningitis groups, IL-4, IL-10, and BDNF levels were increased in the hippocampus, and BDNF levels in the CSF. Conclusions: The data presented suggest that EE, a non-invasive therapy, enables recovery from memory deficits caused by neonatal meningitis.

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Section: Discussioncontrasting

confidence: 72%

Environmental enrichment restores cognitive deficits induced by experimental childhood meningitis

Barichello

Fagundes

Generoso

et al. 2014

Rev. Bras. Psiquiatr.

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“…EE promotes a host of adaptive cognitive and behavioral outcomes, and has been demonstrated to promote both physical and psychological health (20,26–28). Although the details of each EE paradigm vary, they are hypothesized to engage similar neuroplastic mechanisms to influence behavior, and previous attempts have failed to attribute the effects of EE to any single variable (24,29).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Environmental Enrichment on Depressive and Anxiety-Relevant Behaviors in Socially Isolated Prairie Voles

Grippo

Ihm

Wardwell

et al. 2014

Psychosomatic Medicine

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Objectives Social isolation is associated with depression, anxiety and negative health outcomes. Environmental enrichment, including environmental and cognitive stimulation with inanimate objects and opportunities for physical exercise, may be an effective strategy to include in treatment paradigms for affective disorders as a function of social isolation. In a rodent model – the socially monogamous prairie vole – we investigated the hypothesis that depression- and anxiety-related behaviors following social isolation would be prevented and remediated with environmental enrichment. Methods Experiment 1 investigated the preventive effects of environmental enrichment on negative affective behaviors when administered concurrently with social isolation. Experiment 2 investigated the remediating effects of enrichment on negative affective behaviors when administered following a period of isolation. Behaviors were measured in 3 operational tests: open field; forced swim test; and elevated plus maze. Results In isolated prairie voles, enrichment prevented depression- (immobility in FST, group × housing interaction, P=0.049) and anxiety-relevant behaviors (exploration in open field, group × housing interaction, P=0.036; exploration in elevated plus maze, group × housing interaction, P=0.049). Delayed enrichment also remediated these behaviors in isolated animals (immobility in forced swim test, main effect of housing, P=0.001; exploration in open field, main effect of housing, P=0.047; exploration in elevated plus maze, main effect of housing, P=0.001), and was slightly more effective than physical exercise alone in remediating anxiety-relevant behaviors. Conclusions These findings provide insight into the beneficial effects of an enriched environment on depression- and anxiety-relevant behaviors using a translational rodent model of social isolation.

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“…While we use rats, Buschert and colleagues (2016) employed male CD-1 mice which are well known to become aggressive when housed in EE (McQuaid et al, 2012;McQuaid et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Environmental influences on placental programming and offspring outcomes following maternal immune activation

Estevez

Rondón-Ortiz

Nguyen

et al. 2019

Preprint

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Adverse experiences during pregnancy induce placental programming, affecting the fetus and its developmental trajectory. However, the influence of 'positive' maternal experiences on the placenta and fetus remain unclear. In animal models of early life stress, environmental enrichment (EE) has ameliorated and even prevented associated impairments in brain and behavior. Here, using a maternal immune activation (MIA) model in rats, we test whether EE attenuates maternal, placental and/or fetal responses to an inflammatory challenge, thereby offering a mechanism by which fetal programming may be prevented. Moreover, we evaluate life-long EE exposure on offspring development and examine a constellation of genes and epigenetic writers that may protect against MIA challenges. In our model, maternal plasma corticosterone and interleukin-1β were elevated 3 h after MIA, validating the maternal inflammatory response. Evidence for developmental programming was demonstrated by a simultaneous decrease in the placental enzymes Hsd11b2 and Hsd11b2/Hsd11b1, suggesting disturbances in glucocorticoid metabolism. Reductions of Hsd11b2 in response to challenge is thought to result in excess glucocorticoid exposure to the fetus and altered glucocorticoid receptor expression, increasing susceptibility to behavioral impairments later in life. The placental, but not maternal, glucocorticoid implications of MIA were attenuated by EE. There were also sustained changes in epigenetic writers in both placenta and fetal brain as a consequence of environmental experience and sex. Following MIA, both male and female juvenile animals were impaired in social discrimination ability. Life-long EE mitigated these impairments, in addition to the sex specific MIA associated disruptions in central Fkbp5 and Oprm1. These data provide the first evidence that EE protects placental functioning during stressor exposure, underscoring the importance of addressing maternal health and well-being throughout pregnancy. Future work must evaluate critical periods of EE use to determine if postnatal EE experience is necessary, or if prenatal exposure alone is sufficient to confer protection.

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Environmental enrichment influences brain cytokine variations elicited by social defeat in mice

Cited by 43 publications

References 45 publications

Environmental enrichment restores cognitive deficits induced by experimental childhood meningitis

Environmental enrichment restores cognitive deficits induced by experimental childhood meningitis

The Effects of Environmental Enrichment on Depressive and Anxiety-Relevant Behaviors in Socially Isolated Prairie Voles

Environmental influences on placental programming and offspring outcomes following maternal immune activation

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