volume 28, issue 3, P497-501 2012
DOI: 10.3233/jad-2011-111562
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Sangmook Lee, Vanessa Doulames, Michelle Donnelly, James Levasseaur, Thomas B. Shea

Abstract: Alzheimer's disease encompasses multiple risk factors; convergence may be necessary for clinical manifestation. Mice received a complete diet or one lacking folate and vitamin E and containing iron as a pro-oxidant, in a standard environment (SE) or a large cage containing objects to stimulate exploration/activity (enriched environment; EE). Mice declined in maze navigation on the deficient versus complete diet in the SE but not the EE. Mice on the complete diet demonstrated superior performance in the EE vers…

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