Environmental dissemination of mcr-1 positive Enterobacteriaceae by Chrysomya spp. (common blowfly): An increasing public health risk

Qin, Yang; Tansawai, Uttapoln; Andrey, Diego O.; Wang, Shaolin; Yang, Wang; Sands, Kirsty; Kiddee, Anong; Assawatheptawee, Kanit; Bunchu, Nophawan; Hassan, Brekhna; Walsh, Timothy R.; Niumsup, Pannika R.

doi:10.1016/j.envint.2018.11.021

Cited by 28 publications

(25 citation statements)

References 64 publications

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“…As in our study, IncI2 plasmids carrying mcr-1 were reported in wild birds from Argentina (5) and Pakistan (6). IncX4 plasmids, which appear to be a globally major source of mobility and dissemination of mcr-1 gene (2), were described in Enterobacterales in penguins in Brazil 7, common blowflies from urban and rural communities in Thailand (11), and stable flies in Germany (12). At the time of writing this article, eleven mcr-1-positive E. coli isolates from clinical sources with phenotypic colistin resistance (MIC Ͼ 4 mg liter Ϫ1 ) have been reported in Russia (22).…”

supporting

confidence: 72%

“…Plasmid-mediated colistin resistance gene mcr-1 has been described in more than 40 countries, with the majority of reports coming from inpatients and domestic animals. Until now, only a few studies observed this resistance mechanism in bacteria from wildlife (4)(5)(6)(7)(8)(9)(10)(11)(12). In this study, we describe an Escherichia coli isolate with mcr-1 from a migratory wild bird, the black kite (Milvus migrans), in Russia, which is to our best knowledge the first report of plasmid-mediated colistin resistance in wildlife in that country.…”

mentioning

confidence: 89%

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Plasmid-Mediated mcr-1 Colistin Resistance in Escherichia coli from a Black Kite in Russia

Tarabai

Valček

Jamborová

et al. 2019

Antimicrob Agents Chemother

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The gene mcr-1 conferring resistance to last-line antibiotic colistin has been reported globally. Here, we describe the first detection of plasmid-mediated colistin resistance in Russian wildlife, an isolate of Escherichia coli sequence type 2280 from a black kite (Milvus migrans) scavenging raptor. Whole-genome sequencing and plasmid transferability experiments revealed that mcr-1.1 was located on conjugative IncI2 plasmid pDR164 (59891 bp). Migratory black kites may contribute to the global spread of mobile colistin resistance.

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confidence: 72%

mentioning

confidence: 89%

Plasmid-Mediated mcr-1 Colistin Resistance in Escherichia coli from a Black Kite in Russia

Tarabai

Valček

Jamborová

et al. 2019

Antimicrob Agents Chemother

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“…AMR has become an area of focus over the past two decades and is now recognized as a potential and serious threat to global public health ( Tacconelli et al, 2018 ). AMRs can be disseminated rapidly through various pathways, including foodborne pathogens, insects, wastewater, pet, food-production, or wild animals ( Yang Q.E. et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Characteristics and Epidemiology of Extended-Spectrum β-Lactamase-Producing Multidrug-Resistant Klebsiella pneumoniae From Red Kangaroo, China

et al. 2020

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Due to its drug resistant nature, β-lactamase represents a serious challenge for public health. Extended-spectrum β-lactamase (ESBL) producing Klebsiella pneumoniae clones are increasingly reported worldwide. Little is known about the prevalence and biological characteristics of drug-resistant strains in zoos. During routine surveillance at the Zhengzhou Zoo of China, we found Klebsiella pneumoniae isolate in healthy Red Kangaroos ( Macropus Rufus ) with severe MDR. The Klebsiella pneumoniae were especially resistant to Cefuroxime Sodium (MIC, > 64 μg/mL), Ceftriaxone (MIC, >8 μg/mL) and Cefepime (MIC, >64 μg/mL), and belonged to ST290. Subsequently, whole genome sequencing (WGS) showed that the Chrome Chr-M297-1 harbored bla DHA–3 , bla SHV–1 , bla CTX–M–14 , fosA5 , dfrA3 , sul3 , etc., and pM297-1.1 [222,864 bp, IncFIB(K)], which carried nine antimicrobial genes including bla CTX–M–14 , bla TEM–191 , aph(3″)-Ib , aph(6)-Id and qnrS1 , etc., and pM297-1.2 [225,763 bp, IncFII(K)] carried 22 antimicrobial genes including bla TEM–1 , bla CTX–M–3 , aph(3′)-Ia , aac(3)-IIa , aac(6′)-Ib-cr , aadA16 , qnrB2 , qnrS1 , qacEΔ1 , mphA , sul1 , and dfrA27 , etc. A traceability analysis then revealed that these two plasmids were highly similar to those recovered from human clinical samples in some southern cities in Sichuan Province, China (>99%), suggesting that these plasmids are spreading in China. Furthermore, two plasmids harboring conjugal transfer genes facilitated the transmission of antimicrobial genes by conjugation with E. coli J53. Our research shows that the transmission and adaptation of Klebsiella pneumoniae producing ESBLs is occurring in zoo environments, suggesting that zoos may be becoming important potential reservoirs for clinically important drug-resistant genes. It is therefore necessary to monitor the emergence and spread of drug-resistant gene strains in captive wild animals held in zoo environments.

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“…Flies were postulated to be one of the important vectors for transmission of antibiotic-resistant bacteria in the community, including on animal farms [24]. Although several studies from China and Thailand found colistin-resistant bacteria in flies [15,16,25], our study isolated only ESBL-producing E. coli from flies. This may be due to the fact that the flies in our study were caught in an urban area, whereas other studies were conducted in rural areas with animal farms where colistin-resistant bacteria were usually present.…”

Section: Discussionmentioning

confidence: 77%

“…However, the information on antibiotic-resistant bacteria in the environment in Thailand is limited. Contamination by antibiotic-resistant bacteria in the Chao Phraya River and its tributaries [14], in flies [15,16], and in migratory birds [17] in Thailand was reported.…”

Section: Introductionmentioning

confidence: 99%

Contamination by Antibiotic-Resistant Bacteria in Selected Environments in Thailand

Thamlikitkul

Tiengrim

Thamthaweechok

et al. 2019

IJERPH

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This study determined the presence of important antibiotic-resistant bacteria in selected environments in Thailand, including wastewater samples from 60 hospitals; washed fluid, leachate, flies, cockroaches, and rats collected from five open markets; washed fluid from garbage trucks; and stabilized leachate from a landfill facility. At least one type of antibiotic-resistant bacteria was isolated from all samples of influent fluid before treatment in hospitals, from wastewater treatment tank content in hospitals, and from 15% of effluent fluid samples after treatment with chlorine prior to draining it into a public water source. Antibiotic-resistant bacteria were recovered from 80% of washed market fluid samples, 60% of market leachate samples, all fly samples, 80% of cockroach samples, and all samples of intestinal content of rats collected from the open markets. Antibiotic-resistant bacteria were recovered from all samples from the landfill. Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and/or Klebsiella pneumoniae were the most common antibiotic-resistant bacteria recovered from all types of samples, followed by carbapenem-resistant E. coli and/or K. pneumoniae. Colistin-resistant Enterobacteriaceae, carbapenem-resistant Psuedomonas aeruginosa, carbapenem-resistant Acinetobacter baumannii, colistin-resistant Enterobacteriaceae, vancomycin-resistant Enterococci, and methicillin-resistant S. aureus were less common. These findings suggest extensive contamination by antibiotic-resistant bacteria in hospital and community environment in Thailand.

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Environmental dissemination of mcr-1 positive Enterobacteriaceae by Chrysomya spp. (common blowfly): An increasing public health risk

Cited by 28 publications

References 64 publications

Plasmid-Mediated mcr-1 Colistin Resistance in Escherichia coli from a Black Kite in Russia

Plasmid-Mediated mcr-1 Colistin Resistance in Escherichia coli from a Black Kite in Russia

Characteristics and Epidemiology of Extended-Spectrum β-Lactamase-Producing Multidrug-Resistant Klebsiella pneumoniae From Red Kangaroo, China

Contamination by Antibiotic-Resistant Bacteria in Selected Environments in Thailand

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