Environmental changes modify the expression of Diazepam withdrawal

Pérez, Mariela Fernanda; Maglio, Laura E.; Marchesini, Gerardo; Molina, Juan Carlos; Ramírez, Oscar A.

doi:10.1016/s0166-4328(02)00108-0

Cited by 21 publications

(20 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Electrophysiological experiments were carried out using the in vitro hippocampal slice preparation described elsewhere by Pérez et al, 2002. Briefly, rats were sacrificed by cervical dislocation between 11:00 and 12:00 a.m. to prevent variations caused by circadian rhythms or nonspecific stressors Discena, 1984, 1987).…”

Section: Electrophysiological Proceduresmentioning

confidence: 99%

Huperzia saururus, activity on synaptic transmission in the hippocampus

Ortega

Vallejo

Cabrera

et al. 2006

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Section: Electrophysiological Proceduresmentioning

confidence: 99%

Huperzia saururus, activity on synaptic transmission in the hippocampus

Ortega

Vallejo

Cabrera

et al. 2006

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…Different areas of the brain have been involved in the manifestation of withdrawal, for instance, LC, amygdala, and raphe nucleus (Christie et al, 1997). Furthermore, a significant increase in hippocampal synaptic plasticity during withdrawal following dis- Ctrol 13,44;VEH 9,34;51;39;23;72. continuation of chronic DZ administration has been described (Pérez et al, 2002).…”

Section: Discussionmentioning

confidence: 60%

“…Chronic diazepam administration for 18 days enhances hippocampal synaptic plasticity, a phenomenon that persists during withdrawal. These phenomena have a strong dependency on the drug administration context, since both are reversed after the introduction of some changes in the drug administration environment (Pérez et al, 2002). In conjunction with an increased hippocampal synaptic plasticity, we have observed central noradrenergic (NA) activation, revealed by a hyperactivity of locus coeruleus NA neurons in rat, producing physical signs of dependence (Pérez et al, 2001).…”

Section: Introductionmentioning

confidence: 86%

“…Rats from the nondependent group (DZ-NDEP) exhibited no signs of anxiety, in spite of the chronic 18 days DZ administration. These effects were previously reported by our laboratory (Pérez et al, 2002). Previous MK-801 (0.045 mg/kg i.p.)…”

Section: Statisticsmentioning

confidence: 99%

“…The aim of the present study is to gain further insight into the involvement of the 5-HT system in the possible neural circuitry recruited during DZ withdrawal and on the increased hippocampal synaptic plasticity associated with the discontinuation of chronic DZ administration (Pérez et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Participation of dorsal raphe nucleus in the behavioral alteration observed after discontinuation of chronic diazepam administration: Possible neural circuitry involved

Almirón

Ramírez

2005

Synapse

View full text Add to dashboard Cite

Previous findings from our laboratory have demonstrated a positive correlation between the development of tolerance to diazepam (DZ) 5 mg/kg/day over 4 days, and increased hippocampal synaptic plasticity. It seems likely that a similar plastic phenomenon may occur on hippocampal formation after chronic (18 days) DZ administration. We postulate hippocampal long-term potentiation (LTP) underlying substrate to the behavioral alteration observed after chronic DZ administration. In the present study, we investigated the involvement of the serotonergic (5-HT) system in the possible neural circuitry recruited during DZ withdrawal and in the increased hippocampal synaptic plasticity associated with the discontinuation of chronic DZ administration. The results of the current research demonstrate an increased neuronal activity in the dorsal raphe nucleus (DRN) during withdrawal. Previous MK-801 administration impairs the development of anxiety signs observed during withdrawal and the concomitant increased electrical activity on 5-HT neurons on DRN. These results are discussed in terms of the participation of 5-HT system in the modulation of hippocampal plasticity developed on DZ withdrawal.

show abstract

Changes in hippocampal arc protein expression and synaptic plasticity by the presentation of contextual cues linked to drug experience

Monti

Almirón

Bignante

et al. 2010

Synapse

View full text Add to dashboard Cite

Contextual cues linked to drug experience have been frequently associated to craving and relapse, with this phenomenon being described in human and experimental animals. Hippocampal synaptic plasticity has been related to learning, memory, and adaptive processes developed during chronic administration of drug abuse. In this study, we investigated if the environmental context associated with withdrawal experience was able to evoke the same behavioral alteration observed after chronic benzodiazepine administration. Furthermore, we studied the hippocampal synaptic plasticity and anatomical expression of Arc protein during withdrawal and the re-exposure to the context associated with anxiety expression (characteristic sign of benzodiazepines withdrawal). It was demonstrated that re-exposure evoked on days 15 and 25 after the first exposure the same behavior. An increased hippocampal synaptic plasticity, expressed as a lower threshold to induce long-term potentiation on dentate gyrus, was observed in animals dependent on diazepam and during retrieval, in the same group, until day 15. This plastic change disappeared 25 days after the first exposure. An overexpression of Arc protein in the dorsal dentate gyrus and CA1 on the first day of withdrawal in the dependent animals was observed.

show abstract

Environmental changes modify the expression of Diazepam withdrawal

Cited by 21 publications

References 24 publications

Huperzia saururus, activity on synaptic transmission in the hippocampus

Huperzia saururus, activity on synaptic transmission in the hippocampus

Participation of dorsal raphe nucleus in the behavioral alteration observed after discontinuation of chronic diazepam administration: Possible neural circuitry involved

Changes in hippocampal arc protein expression and synaptic plasticity by the presentation of contextual cues linked to drug experience

Contact Info

Product

Resources

About