Environment and cardiovascular health: causes, consequences and opportunities in prevention and treatment

Bañeras, Jordi; Iglesies-Grau, Josep; Téllez-Plaza, María; Arrarte, Vicente; Báez-Ferrer, Néstor; Benito, Begoña; Ruiz, Raquel Campuzano; Cecconi, Alberto; Rodríguez‐Sinovas, Antonio; Ujueta, Francisco; Vozzi, Carlos; Lamas, Gervasio A.; Navas‐Acien, Ana

doi:10.1016/j.rec.2022.05.030

Cited by 3 publications

(3 citation statements)

References 90 publications

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“…The concentrations of pollutants that affect air quality can vary notoriously in a matter of a few days, depending on the daily emissions and particularly on the meteorological conditions. Due to variations in wind speed, the vertical stability of the atmosphere, or the arrival of polluted air from other regions, the concentrations of these pollutants may vary between 50-500% in just a few days [11].…”

Section: Discussionmentioning

confidence: 99%

“…A recent study in Spain found no association between PM10 concentrations derived from desert dust and the incidence of CD [15]. It therefore may be inferred that cardiovascular pathophysiology may differ in terms of the impact of PM10 generated by combustion processes and those of natural origin (desert dust), suggesting likely variations in their influence [1,11,16,17].…”

Section: Discussionmentioning

confidence: 99%

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Influence of desert dust on the development of premature coronary disease

Dominguez-Rodriguez,

Báez-Ferrer,

Avanzas

et al. 2024

Preprint

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Objectives: Recently, desert dust in Europe has been recognized as a cardiovascular health problem. In Spain, desert dust inflows in recent years have been associated with worsening air quality. The present study examines whether desert dust events are related to the incidence of acute coronary syndrome (ACS) in patients under 55 years of age. Methods: Data from 2416 consecutive patients admitted to a tertiary hospital due to ACS were prospectively analyzed. A case-crossover time-stratified design using Poisson conditional regression models was applied to estimate the impact of desert dust events involving particulate matter concentrations of aerodynamic diameter < 10 μm (PM10) on the incidence of ACS. Results: Desert dust intrusion on days 0 to 5 after ACS onset showed no significant association with the incidence of ACS in patients under 55 years of age. The incidence rate ratios of PM10 concentrations 1, 2, 3, 3, 4 and 5 days before ACS onset (for changes of 10 µg/m3) were 1.02 (95% CI 0.97-1.1; p = 0.41), 1.01 (95% CI 0.96-1.07; p = 0.66), 0.99 (95% CI 0.94-1.05; p = 0.78), 0.96 (95% CI 0.9-1.02; p = 0.18) and 0.97 (95% CI 0.91-1.04; p = 0.41). Conclusions: Our findings suggest that desert dust is unlikely to be related to the incidence of premature coronary heart disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Influence of desert dust on the development of premature coronary disease

Dominguez-Rodriguez,

Báez-Ferrer,

Avanzas

et al. 2024

Preprint

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“… 6 These links and the efforts to understand and act on them have been termed environmental cardiology . 7 , 8 Although the European Society of Cardiology and the American Heart Association have considered air pollution as a cardiovascular risk factor, to date, medical societies have not uniformly focused on vascular toxicity from contaminant metals.…”

Section: Perspective On Contaminant Metals and Cardiovascular Riskmentioning

confidence: 99%

Contaminant Metals as Cardiovascular Risk Factors: A Scientific Statement From the American Heart Association

Lamas¹,

Bhatnagar²,

Jones³

et al. 2023

JAHA

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Exposure to environmental pollutants is linked to increased risk of cardiovascular disease. Beyond the extensive evidence for particulate air pollution, accumulating evidence supports that exposure to nonessential metals such as lead, cadmium, and arsenic is a significant contributor to cardiovascular disease worldwide. Humans are exposed to metals through air, water, soil, and food and extensive industrial and public use. Contaminant metals interfere with critical intracellular reactions and functions leading to oxidative stress and chronic inflammation that result in endothelial dysfunction, hypertension, epigenetic dysregulation, dyslipidemia, and changes in myocardial excitation and contractile function. Lead, cadmium, and arsenic have been linked to subclinical atherosclerosis, coronary artery stenosis, and calcification as well as to increased risk of ischemic heart disease and stroke, left ventricular hypertrophy and heart failure, and peripheral artery disease. Epidemiological studies show that exposure to lead, cadmium, or arsenic is associated with cardiovascular death mostly attributable to ischemic heart disease. Public health measures reducing metal exposure are associated with reductions in cardiovascular disease death. Populations of color and low socioeconomic means are more commonly exposed to metals and therefore at greater risk of metal‐induced cardiovascular disease. Together with strengthening public health measures to prevent metal exposures, development of more sensitive and selective measurement modalities, clinical monitoring of metal exposures, and the development of metal chelation therapies could further diminish the burden of cardiovascular disease attributable to metal exposure.

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AnIn-VitroStandardized Protocol for Preparing Smoke Extract Media from Cigarette, Electronic Cigarette and Waterpipe

Al-Hashimi,

Shah,

Carpenter

et al. 2024

Preprint

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Cigarette smoke exposure is a major risk factor for various diseases, and in vitro studies using smoke medium (SM) are crucial for elucidating underlying mechanisms. However, the lack of standardized protocols for SM preparation has led to inconsistencies in experimental results. This paper presents an optimized protocol for reproducible generation of SM from conventional cigarette smoke extract (CSE), electronic cigarette smoke (ECS), and waterpipe vapour (WPV). The protocol involves:A custom-built apparatus for smoke capture in a cell culture mediumSpecific parameters mimicking human smoking topographyRigorous aseptic techniques and safety measuresExtensive details are provided for material preparation, apparatus setup, smoke generation procedures, and post-processing steps. This standardized method enables reliable in vitro exposure models, easing comparative studies across different tobacco products. To prove protocol consistency, we present optical. Additionally, we highlight the protocol’s utility by figuring out the SM quality through analysing O.D. data and morphological changes, cell viability assays, ELISA and gene expression analyses i.e., RNA sequencing through severalin-vitromodels, i.e., Human Umbilical Vein Endothelial Cells, (HUVECs,Merck), human leukaemia monocytic cell line (THP-1, Sigma) and induced pluripotent stem cells differentiated to cardiomyocytes(iPSC-CMs,Axol)respectively. This optimized protocol addresses variability in SM preparation, enabling consistent investigations into smoke-induced pathologies and potential therapeutic interventions.Graphical abstractSpecifications table

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Environment and cardiovascular health: causes, consequences and opportunities in prevention and treatment

Cited by 3 publications

References 90 publications

Influence of desert dust on the development of premature coronary disease

Influence of desert dust on the development of premature coronary disease

Contaminant Metals as Cardiovascular Risk Factors: A Scientific Statement From the American Heart Association

AnIn-VitroStandardized Protocol for Preparing Smoke Extract Media from Cigarette, Electronic Cigarette and Waterpipe

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