2006
DOI: 10.1001/archderm.142.7.942
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Enterovirus Infection as a Possible Cause of Pityriasis Rosea: Demonstration by Immunochemical Staining

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Cited by 11 publications
(7 citation statements)
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“…Standard staining protocol was followed as described previously 18. Briefly, the deparaffinised, hydrated biopsy specimens were treated with 3% H 2 O 2 to remove endogenous peroxidase activity, underwent heat-induced epitope retrieval, blocked with goat serum ±3% bovine serum albumin (BSA), treated with biotin–avidin to remove endogenous biotin in gastric tissue, then incubated sequentially with murine mAb, biotinylated goat anti-mouse antibody (Vectastain ABC reagent, Vector Laboratory), before developing with DAB chromogen.…”
Section: Methodsmentioning
confidence: 99%
“…Standard staining protocol was followed as described previously 18. Briefly, the deparaffinised, hydrated biopsy specimens were treated with 3% H 2 O 2 to remove endogenous peroxidase activity, underwent heat-induced epitope retrieval, blocked with goat serum ±3% bovine serum albumin (BSA), treated with biotin–avidin to remove endogenous biotin in gastric tissue, then incubated sequentially with murine mAb, biotinylated goat anti-mouse antibody (Vectastain ABC reagent, Vector Laboratory), before developing with DAB chromogen.…”
Section: Methodsmentioning
confidence: 99%
“…More objectively, various studies have shown the presence of HHV in the plasma or lesional skin of patients with PR, 2–5 but other studies have shown conflicting results 6,7,9 . Recently, enterovirus infection has also been proposed to be associated with PR 8 …”
Section: Discussionmentioning
confidence: 99%
“…The prodromal symptoms experienced by some patients, the frequent clustering of cases, and the almost complete absence of recurrent episodes, suggest an infectious aetiology 1 . However, results from studies of human herpesvirus (HHV) types 6, 7 and 8 in PR have been inconclusive 2–9 . Previous immunohistological studies of PR have showed the presence of T cells and Langerhans cells within the inflammatory dermal infiltrate of PR lesions, suggesting the possible role of cell‐mediated immunity in PR 10–12 .…”
Section: Introductionmentioning
confidence: 99%
“…Enteroviruses were claimed to have caused PR according to one study. [12] However, it was unfeasible for us to investigate this patient in depth from virological perspectives owing to inadequate resources.…”
Section: Discussionmentioning
confidence: 99%