Enteropathy-associated T-cell lymphoma—a clinicopathologic and array comparative genomic hybridization study

Ko, Young Hyeh; Karnan, Sivasundaram; Kim, Kyeong Mee; Park, Cheol Keun; Kang, Eun Suk; Kim, Young Ho; Kang, Won Ki; Kim, Seok Jin; Kim, Won Seog; Lee, Woo Yong; Chun, Ho Kyung; Seto, Masao

doi:10.1016/j.humpath.2009.11.020

Cited by 63 publications

(74 citation statements)

References 18 publications

(32 reference statements)

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“…Two occurred in the colon, two occurred both in the small intestine and colon, and one involved the stomach, small intestine, and colon non-contiguously. A similar result was obtained by Ko et al,18 who found that only two of eight type II enteropathy-associated T-cell lymphoma cases were confined to the small intestine. These results suggest that, unlike most type I enteropathy-associated T-cell lymphoma cases were confined to the small intestine, type II enteropathy-associated T-cell lymphoma was more likely to occur in the ileocecum and the colon.…”

Section: Discussionsupporting

confidence: 86%

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Primary intestinal T-cell and NK-cell lymphomas: a clinicopathological and molecular study from China focused on type II enteropathy-associated T-cell lymphoma and primary intestinal NK-cell lymphoma

et al. 2011

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Section: Discussionsupporting

confidence: 86%

“…As type II enteropathy-associated T-cell lymphoma was introduced, several reports about this lymphoma from East Asia have been published. [17][18][19] In these reports, none of the patients had gluten-sensitive malabsorption syndrome. The definition of enteropathy varies among studies 17,20 and may influence the lymphoma classification.…”

Section: Discussionmentioning

confidence: 93%

Primary intestinal T-cell and NK-cell lymphomas: a clinicopathological and molecular study from China focused on type II enteropathy-associated T-cell lymphoma and primary intestinal NK-cell lymphoma

et al. 2011

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“…This observation is consistent with a recent study of EATL in 18 Chinese patients, which also showed only type II histology [10]. In several previous studies of intestinal T-cell lymphomas in Asian patients [6][7][8][9]11,12,17,18], type II EATL was also predominantly observed, although fewer than 10 cases of apparently classical EATL were described. However, the diagnosis of classical EATL in these few cases had been queried, based on the lack of stringency in diagnosis, doubtful histologic features, and immunophenotypes that would in fact be consistent with type II EATL [10].…”

Section: Discussionsupporting

confidence: 92%

“…Only a few case series of EATL have been reported from Asian populations [6][7][8][9][10][11], in whom celiac disease is rare. Interestingly, convincing cases of classical EATL cannot be identified from these publications.…”

Section: Introductionmentioning

confidence: 99%

Type II enteropathy‐associated T‐cell lymphoma: A multicenter analysis from the Asia Lymphoma Study Group

et al. 2012

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Enteropathy-associated T-cell lymphoma (EATL) is a rare primary gastrointestinal T-cell lymphoma. A multicenter study from the Asia Lymphoma Study Group identified 38 EATL patients within a 19-year period. All cases were type II EATL. Men were affected twice as common as women, at a median age of 59 (23-89) years. None had a history of celiac disease. The sites of involvement were small bowel and stomach (5%), small bowel (63%), small and large bowel (16%), and large bowel (18%). Common presenting features were bowel perforation (34%), pain (32%), and obstruction (21%). Lymphomas showed monomorphic neoplastic lymphoid infiltrates that were CD3 1 (100%), CD56 1 (91%), TIA-1 1 (96%), CD4 -CD8 1 (63%), CD4 1 CD8 1 (19%), CD4 -CD8 -(16%), and CD4 1 CD8 -(3%). Epstein Barr virus was demonstrable in three cases. Despite chemotherapy and/or surgical resection, the overall response and complete response rates were poor at 46% and 38%. The median overall survival (OS) was 7 months and progression-free-survival (PFS) 1 month. Five patients underwent hematopoietic stem cell transplantation all were alive. Age and the prognostic index for peripheral T-cell lymphoma were not prognostically significant. Good performance status was associated with better OS (P 5 0.03), and response to initial treatment led to better OS and PFS (P < 0.001). Am. J. Hematol. 87:663-668, 2012. V

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“…22 Enteropathy-associated T-cell lymphoma has frequent gains at 9q33 that not are not seen in other T-cell lymphomas. 23,24 In spite of the marked heterogeneity of the genomic profiles in different lymphoma types, some alterations are recurrently seen across different entities, suggesting that they may deregulate crucial genes or pathways in the biology of the tumors, independent of the cell type. For instance, deletions of 17p targeting TP53 and homozygous deletions of 9p21 including CDKN2A are seen in aggressive forms of different lymphomas.…”

Section: Platformsmentioning

confidence: 99%

Whole genome profiling and other high throughput technologies in lymphoid neoplasms—current contributions and future hopes

Campo

2013

Modern Pathology

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The development of high throughput technologies based on the knowledge of the human genome has opened the possibility to search for global genomic alterations in tumors responsible for their development and progression that may have important clinical implications. One of the major applications of this genomic knowledge has been the design of different types of microarray platforms for the analysis of DNA alterations and gene expression profiling (GEP). The main contributions of the DNA studies in lymphoid neoplasms include the definition of relatively characteristic genomic profiles for specific disease entities, the demonstration of common chromosomal alterations across entities, the identification of genes and pathways targeted by the altered chromosomal regions, and the identification of chromosomal alterations with prognostic implications. RNA GEP studies in these tumors have enhanced the molecular characterization of known entities and facilitated the recognition of new subtypes and categories of lymphoid neoplasms, the identification of new biomarkers and prognostic models, and the detection of oncogenic pathways with potential implications for targeted therapies. The recent development of the next generation sequencing (NGS) technologies and its application in lymphoid neoplasms already have provided an initial view of the complex landscape of somatic mutations in these tumors and some findings with important functional and clinical implications. This review addresses the major contributions and limitations of the microarray technologies in the understanding of lymphoid neoplasms and discusses how this knowledge may be transferred into the clinics. The initial results of the NGS studies are also presented.

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Enteropathy-associated T-cell lymphoma—a clinicopathologic and array comparative genomic hybridization study

Cited by 63 publications

References 18 publications

Primary intestinal T-cell and NK-cell lymphomas: a clinicopathological and molecular study from China focused on type II enteropathy-associated T-cell lymphoma and primary intestinal NK-cell lymphoma

Primary intestinal T-cell and NK-cell lymphomas: a clinicopathological and molecular study from China focused on type II enteropathy-associated T-cell lymphoma and primary intestinal NK-cell lymphoma

Type II enteropathy‐associated T‐cell lymphoma: A multicenter analysis from the Asia Lymphoma Study Group

Whole genome profiling and other high throughput technologies in lymphoid neoplasms—current contributions and future hopes

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