Journal of Cell Biology volume 218, issue 2, P541-558 2019 DOI: 10.1083/jcb.201708105 View full text
Khaled Hached, Perrine Goguet, Sophie Charrasse, Suzanne Vigneron, Maria P. Sacristan, Thierry Lorca, Anna Castro

Abstract: Greatwall (GWL) is an essential kinase that indirectly controls PP2A-B55, the phosphatase counterbalancing cyclin B/CDK1 activity during mitosis. In Xenopus laevis egg extracts, GWL-mediated phosphorylation of overexpressed ARPP19 and ENSA turns them into potent PP2A-B55 inhibitors. It has been shown that the GWL/ENSA/PP2A-B55 axis contributes to the control of DNA replication, but little is known about the role of ARPP19 in cell division. By using conditional knockout mouse models, we investigated the specifi…

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