Enhancing Triple Negative Breast Cancer Immunotherapy by ICG‐Templated Self‐Assembly of Paclitaxel Nanoparticles

Feng, Bing; Niu, Zifei; Hou, Bo; Zhou, Lei; Li, Yaping

doi:10.1002/adfm.201906605

Cited by 155 publications

(118 citation statements)

References 68 publications

Supporting

Mentioning

115

Contrasting

Order By: Relevance

“…Chemotherapy is still one of the main methods of clinical treatment, but it is limited by drug resistance, poor targetin. 48 In immunotherapy, immune checkpoint blockade (ICB) therapy is applied for immune escape. However, ICB therapy is limited due to poor immunogenicity, and even immunosuppressive tumor microenvironment (ITM).…”

Section: The Other Synergistic Treatment Methodsmentioning

confidence: 99%

Tumor therapy based on self‐assembling peptides nanotechnology

Xing

Yuan

et al. 2020

VIEW

View full text Add to dashboard Cite

Self-assembling peptides display great potential in biological and medical applications, especially tumor therapy with noninvasive ways. The rapid expansion of self-assembling peptides is almost on account of their favorable biocompatibility, tumor microenvironment responsiveness, multivalency, and structural versatility. With taking full advantage of self-assembling peptide peculiarities, peptide-based nanomaterials are applied for delivery carriers, chemotherapy, immunotherapy, and noninvasive tumor treatments including photothermal therapy (PTT), photodynamic therapy (PDT), and sonodynamic therapy (SDT). In addition, immunogenic cell death of tumor cells originating from PDT and SDT, and the necrosis of tumor cells due to PTT can elicit some degree of immune responses. Therefore, synergistic therapy has served as a more effective and powerful strategy for tumor therapy. Importantly, self-assembling peptides are capable of subtly making combination of various treatments. This review outlines biomedical applications of nanomaterials based on self-assembling peptides with emphasizing variegated treatment methods.

show abstract

Section: The Other Synergistic Treatment Methodsmentioning

confidence: 99%

Tumor therapy based on self‐assembling peptides nanotechnology

Xing

Yuan

et al. 2020

VIEW

View full text Add to dashboard Cite

show abstract

“…After a combined application with aPD‐L1, it shows a synergistic anti‐tumor effect. Therefore, self‐assembled nanomedicine using ICG as a template may represent a reliable new strategy for immunotherapy [96] …”

Section: Combination Of Nanotechnology‐based Immune Checkpoint Blockimentioning

confidence: 99%

Combined Application of Nanotechnology and Multiple Therapies with Tumor Immune Checkpoints

Sun

et al. 2020

ChemistrySelect

View full text Add to dashboard Cite

Tumor immunotherapy has received worldwide attention in cancer treatment owing to its apparent advantages, such as strong specificity and long curative effect. Among them, significant progress has been made on the immune checkpoint therapy in recent years. FDA approved PD‐L1/PD‐1 and CTLA‐4 immune checkpoint inhibitors have been broadly used in a variety of malignant tumors. However, because of the low response rate of immune checkpoint drugs, its clinical application has been greatly hindered. With the prominence of nanotechnology in bio‐medicine, the application of nanotechnology in immune checkpoints has also gained more and more attention. The combination of radiotherapy, chemotherapy, phototherapy, magnetic therapy and other methods in nanotechnology makes an excellent promoting effect in the treatment of immune checkpoint drugs. This article reviews the recent breakthroughs of nanotechnology in immune checkpoint blocking therapy, mainly focusing on the significant advantages of the combination of nanotechnology‐based immune checkpoint blocking therapy with other treatment methods. In addition, we also discussed the challenges in this area and pointed out some potential directions for future development.

show abstract

“…The stimuli‐activatable nanomedicine allows spatiotemporal control of the therapeutic effect at the site of interest, which is crucial for improved cancer therapy (Y. Liu, Bhattarai, et al, ; Y. Zhang et al ). In the past decades, multifunctional nanoplatforms have been extensively exploited to improve the therapeutic efficiency upon exogenous and/or endogenous triggers, such as hyperthermia (B. Feng, Hou, et al, ; H. Sun et al, ), tumor acidity (T. Wang et al, ; G. Yang, Xu, et al, ), and reactive oxygen species (ROS; B. Feng, Niu, et al, ; A. Gao, Chen, et al, ; F. Zhou et al, ). However, the development of stimuli‐activatable nanoplatforms applicable for a large variety of cancers remains a significant challenge owing to the high heterogeneity of the solid tumors.…”

Section: Introductionmentioning

confidence: 99%

Stimuli‐activatable nanomedicines for chemodynamic therapy of cancer

Wang

Jin

et al. 2020

WIREs Nanomed Nanobiotechnol

Self Cite

View full text Add to dashboard Cite

Chemodynamic therapy (CDT) takes the advantages of Fenton‐type reactions triggered by endogenous chemical energy to generate highly cytotoxic hydroxyl radicals. As a novel modality for cancer treatment, CDT shows minimal invasiveness and high tumor specificity by responding to the acidic and the highly concentrated hydrogen peroxide microenvironment of tumor. The CDT approach for spatiotemporal controllable reactive oxygen species generation exhibits preferable therapeutic performance and satisfying biosafety. In this review article, we summarized the recent advances of stimuli‐activatable nanomedicines for CDT. We also overviewed the strategies for augmenting CDT performance, including increasing the catalytic efficacy through rational design of the nanomaterials, modulating the reaction condition, inputting external energy field, and regulating the tumor microenvironment. Furthermore, we discussed the potential and challenges of stimuli‐activatable nanomedicine for clinical translation and future development of CDT. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Diagnostic Tools > In Vivo Nanodiagnostics and Imaging

show abstract

Enhancing Triple Negative Breast Cancer Immunotherapy by ICG‐Templated Self‐Assembly of Paclitaxel Nanoparticles

Cited by 155 publications

References 68 publications

Tumor therapy based on self‐assembling peptides nanotechnology

Tumor therapy based on self‐assembling peptides nanotechnology

Combined Application of Nanotechnology and Multiple Therapies with Tumor Immune Checkpoints

Stimuli‐activatable nanomedicines for chemodynamic therapy of cancer

Contact Info

Product

Resources

About